Stimulus-responsive hydrogels: A potent tool for biosensing in food safety

Lin, Xiangmin; Jia, Xuexia; Chen, Ruipeng; Qin, Yingkai; Bian, Yalan; Wei, Sheng; Li, Shuang; Gao, Zhixian

doi:10.1016/j.tifs.2022.12.002

Cited by 18 publications

(3 citation statements)

References 67 publications

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“…In addition, the soil environment and water quality are also closely related to food safety [ 112 , 113 ]. Although the traditional food safety monitoring methods such as high-performance liquid chromatography (HPLC), gas chromatography (GC), and mass spectrometry (MS) have been widely used and can effectively detect food contaminants, there are still some problems that cannot be ignored, such as complex instruments, low detection efficiency, needing well-trained professional and technical personnel and so on [ 114 , 115 ]. Biosensors are increasingly used in food safety monitoring due to their exceptional specificity and sensitivity, fast response time, ease of operation and low cost [ 116 ].…”

Section: Stimulus-responsive Dna Hydrogel Biosensors For Food Safety ...mentioning

confidence: 99%

Stimulus-Responsive DNA Hydrogel Biosensors for Food Safety Detection

Wang

Lai

et al. 2023

Biosensors

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Food safety has always been a major global challenge to human health and the effective detection of harmful substances in food can reduce the risk to human health. However, the food industry has been plagued by a lack of effective and sensitive safety monitoring methods due to the tension between the cost and effectiveness of monitoring. DNA-based hydrogels combine the advantages of biocompatibility, programmability, the molecular recognition of DNA molecules, and the hydrophilicity of hydrogels, making them a hotspot in the research field of new nanomaterials. The stimulus response property greatly broadens the function and application range of DNA hydrogel. In recent years, DNA hydrogels based on stimulus-responsive mechanisms have been widely applied in the field of biosensing for the detection of a variety of target substances, including various food contaminants. In this review, we describe the recent advances in the preparation of stimuli-responsive DNA hydrogels, highlighting the progress of its application in food safety detection. Finally, we also discuss the challenges and future application of stimulus-responsive DNA hydrogels.

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Section: Stimulus-responsive Dna Hydrogel Biosensors For Food Safety ...mentioning

confidence: 99%

Stimulus-Responsive DNA Hydrogel Biosensors for Food Safety Detection

Wang

Lai

et al. 2023

Biosensors

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“…Due to this characteristic, they find a large application in the biomedical field and, in particular, as smart wound dressings, being able to improve wound healing ( Table 1 ). They are also exploited in regenerative medicine, cancer treatment [ 44 , 45 ], drug delivery [ 46 , 47 ], sensing [ 48 , 49 ], and more. Stimuli can be classified mainly as endogenous and exogenous.…”

Section: Stimuli -Responsive Systemsmentioning

confidence: 99%

Recent Advances in Stimuli-Responsive Hydrogel-Based Wound Dressing

Serpico

Iacono

Cammarano³

et al. 2023

Gels

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Polymeric materials have found increasing use in biomedical applications in the last decades. Among them, hydrogels represent the chosen class of materials to use in this field, in particular as wound dressings. They are generally non-toxic, biocompatible, and biodegradable, and they can absorb large amounts of exudates. Moreover, hydrogels actively contribute to skin repair promoting fibroblast proliferation and keratinocyte migration, allowing oxygen to permeate, and protecting wounds from microbial invasion. As wound dressing, stimuli-responsive systems are particularly advantageous since they can be active only in response to specific environmental stimuli (such as pH, light, ROS concentration, temperature, and glucose level). In this review, we briefly resume the human skin’s structure and functions, as well as the wound healing phases; then, we present recent advances in stimuli-responsive hydrogels-based wound dressings. Lastly, we provide a bibliometric analysis of knowledge produced in the field.

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“…Long ssDNA generated using RCA with aptamer sequences ensured the specific anchoring of cells, while the physically cross-linked network exhibited a moderate storage modulus (G ) of about 12 Pa, which could minimize mechanical damage to cells. These studies have shown that RCA technology is a simple, rapid, and cost-effective synthetic method that can be used for the bulk production of DNA hydrogels, and the functionalization of hydrogels can be achieved by programming the circular template sequences and integrating different DNA bio-functional modules (e.g., aptamer, G-quadruplex, i-motif structure) [32][33][34][35]. However, regulatory analysis of the mechanical properties of pure DNA hydrogels made with RCA technology has not been thoroughly explored.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Impact of Hydrogen Bonding Degree in Long Single-Stranded DNA (ssDNA) Generated with Dual Rolling Circle Amplification (RCA) on the Preparation and Performance of DNA Hydrogels

Wang

Zhang

et al. 2023

Biosensors

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DNA hydrogels have gained significant attention in recent years as one of the most promising functional polymer materials. To broaden their applications, it is critical to develop efficient methods for the preparation of bulk-scale DNA hydrogels with adjustable mechanical properties. Herein, we introduce a straightforward and efficient molecular design approach to producing physically pure DNA hydrogel and controlling its mechanical properties by adjusting the degree of hydrogen bonding in ultralong single-stranded DNA (ssDNA) precursors, which were generated using a dual rolling circle amplification (RCA)-based strategy. The effect of hydrogen bonding degree on the performance of DNA hydrogels was thoroughly investigated by analyzing the preparation process, morphology, rheology, microstructure, and entrapment efficiency of the hydrogels for Au nanoparticles (AuNPs)–BSA. Our results demonstrate that DNA hydrogels can be formed at 25 °C with simple vortex mixing in less than 10 s. The experimental results also indicate that a higher degree of hydrogen bonding in the precursor DNA resulted in stronger internal interaction forces, a more complex internal network of the hydrogel, a denser hydrogel, improved mechanical properties, and enhanced entrapment efficiency. This study intuitively demonstrates the effect of hydrogen bonding on the preparation and properties of DNA hydrogels. The method and results presented in this study are of great significance for improving the synthesis efficiency and economy of DNA hydrogels, enhancing and adjusting the overall quality and performance of the hydrogel, and expanding the application field of DNA hydrogels.

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Stimulus-responsive hydrogels: A potent tool for biosensing in food safety

Cited by 18 publications

References 67 publications

Stimulus-Responsive DNA Hydrogel Biosensors for Food Safety Detection

Stimulus-Responsive DNA Hydrogel Biosensors for Food Safety Detection

Recent Advances in Stimuli-Responsive Hydrogel-Based Wound Dressing

Investigation of the Impact of Hydrogen Bonding Degree in Long Single-Stranded DNA (ssDNA) Generated with Dual Rolling Circle Amplification (RCA) on the Preparation and Performance of DNA Hydrogels

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