The Adult Male® and Adult Female® phantoms of ORNL were modified with Ir-192 source and additional tally cards from the MCNP® data library. The lung and eleven soft tissues were used for the study. The soft tissues include Liver, Stomach, Ovaries, Testes, Brain, Thyroid, Kidney, Pancreas, Gall Bladder, Heart, and the Small Intestine. The computational simulation was achieved using MCNPX with nps of 107 , and the data set of the lung and soft tissues derived for Malaysian population [14]. The relative error, R was <0.05 for F4 and the F6 tallies across the energy range studied. The results obtained for 0.1-10.0 MeV energies for the F4 and F6 tallies were used to estimate the mass stopping power, S/ρ (MeVg1 cm2 ) and the linear stopping power, S (MeV/cm). The result compares favorably among the tissues. This result is very relevant and useful in validating an on-going lung and soft tissue model construction