Strain and Complexity, Passerini and Ugi Reactions of Four‐Membered Heterocycles and Further Elaboration of TOSMIC Product

Abstract

Straightforward and general Passerini and Ugi procedures have been developed to incorporate four‐membered heterocycles into highly functionalized scaffolds. Additionally, toslymethyl isocyanide (TosMIC)‐derived Ugi adducts have been prepared, showcasing the prospect of the multicomponent reaction.