PurposeEmployee compliance with information system security policies (ISSPs) has been emphasized as a key factor in protecting information assets against insider threats. Even though previous studies have identified extrinsic factors (in the form of external pressure, rewards and social norms) influencing employee compliance, the functioning of employees' intrinsic motivation has not been clearly analyzed. Thus, the aim of this study is to explore the influence of intrinsic motivations on employees' ISSP compliance.Design/methodology/approachThis study follows a survey approach and conducts structural equation modeling using WarpPLS 5.0 to test the research model and hypotheses. The survey respondents are users of an enterprise digital rights management (EDRM) system.FindingsThe analysis results demonstrate that work impediments, perceived responsibility and self-efficacy significantly influence the intention to comply with ISSP. Additionally, autonomy significantly affects self-efficacy and perceived responsibility. Furthermore, autonomy plays a moderating role in the relationship between work impediment and ISSP compliance intentions.Originality/valueThis study initiatively explores the effect of intrinsic motivations on ISSP compliance intention of employees for a specific information security system (i.e. the EDRM system). This study clarifies the enabling role of intrinsic motivations in ISSP compliance and helps organizations to understand that employee's self-motivated intention, i.e. autonomy, is an essential factor that achieves a higher level of ISSP compliance in the workplace.