Strategies for Bone Regeneration: From Graft to Tissue Engineering

Battafarano, Giulia; Rossi, Michela; Martino, Viviana De; Marampon, Francesco; Borro, Luca; Secinaro, Aurelio; Fattore, Andrea Del

doi:10.3390/ijms22031128

Cited by 159 publications

(114 citation statements)

References 189 publications

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…Effectively, because of the difficulties inherent in in vivo studies, there are relatively few published results and also a great variability of methods, protocols, and animal models that impedes to compare the results obtained by the different research groups. However, most authors trust that the union of MSCs with scaffolds and signal molecules will be the solution [ 131 ], although at this time, it is perceived still far away.…”

Section: Interaction Of Stem Cells With Mesoporous Glasses In Bone Regenerationmentioning

confidence: 99%

Mesoporous bioactive glasses for regenerative medicine

Vallet‐Regí

Salinas

2021

Materials Today Bio

View full text Add to dashboard Cite

Stem cells are the central element of regenerative medicine (RM). However, in many clinical applications, the use of scaffolds fabricated with biomaterials is required. In this sense, mesoporous bioactive glasses (MBGs) are going to play an important role in bone regeneration because of their striking textural properties, quick bioactive response, and biocompatibility. As other bioactive glasses, MBGs are mainly formed by silicon, calcium, and phosphorus oxides whose ions play an important role in cell proliferation as well as in homeostasis and bone remodeling process. A common improvement of bioactive glasses for RM is by adding small amounts of oxides of elements that confer them additional biological capacities, including osteogenic, angiogenic, antibacterial, anti-inflammatory, hemostatic, or anticancer properties. Moreover, MBGs are versatile in terms of the different ways in which they can be processed, such as scaffolds, fibers, coatings, or nanoparticles. MBGs are unique because their textural properties are so high that they still exhibit outstanding bioactive responses even after adding extra inorganic ions or being processed as scaffolds or nanoparticles. Moreover, they can be further improved by loading with biomolecules, drugs, and stem cells. This article reviews the state of the art and future perspectives of MBGs in the field of RM of hard tissues.

show abstract

Section: Interaction Of Stem Cells With Mesoporous Glasses In Bone Regenerationmentioning

confidence: 99%

Mesoporous bioactive glasses for regenerative medicine

Vallet‐Regí

Salinas

2021

Materials Today Bio

View full text Add to dashboard Cite

show abstract

“…In MSC-based tissue engineering approaches, MSCs are incorporated in scaffolds that facilitate the local delivery of MSCs into the bone defects. Scaffold colonization can occur either by cell culture prior to scaffold creation, or by simultaneous deposition of cells and biomaterials [74].…”

Section: Scaffolds As Vehicles Of Cells and Growth Factorsmentioning

confidence: 99%

“…Thus far, bone healing has been shown to be improved when utilizing MSCs with metals, ceramics, and polymeric and composite materials [74]. The scaffolds should provide the proper microenvironment for cells to survive, proliferate, and differentiate in vitro and in vivo.…”

Section: Scaffolds As Vehicles Of Cells and Growth Factorsmentioning

confidence: 99%

A Multidisciplinary Journey towards Bone Tissue Engineering

2021

View full text Add to dashboard Cite

Millions of patients suffer yearly from bone fractures and disorders such as osteoporosis or cancer, which constitute the most common causes of severe long-term pain and physical disabilities. The intrinsic capacity of bone to repair the damaged bone allows normal healing of most small bone injuries. However, larger bone defects or more complex diseases require additional stimulation to fully heal. In this context, the traditional routes to address bone disorders present several associated drawbacks concerning their efficacy and cost-effectiveness. Thus, alternative therapies become necessary to overcome these limitations. In recent decades, bone tissue engineering has emerged as a promising interdisciplinary strategy to mimic environments specifically designed to facilitate bone tissue regeneration. Approaches developed to date aim at three essential factors: osteoconductive scaffolds, osteoinduction through growth factors, and cells with osteogenic capability. This review addresses the biological basis of bone and its remodeling process, providing an overview of the bone tissue engineering strategies developed to date and describing the mechanisms that underlie cell–biomaterial interactions.

show abstract

“…The addition of biologically active polypeptides chain patterns (RGD, which is also known as arginine-glycine and aspartic acid tripeptide chain) is detected by intercellular trans-membrane receptorintegrin, which is one of the most primarily adopted techniques for improved function. 91 Cell reaction is often unique to specific binding affinities of certain ligand surface densities, which is always bi-phasic like migration response and can be modulated with collocating synergistic ligands. 92 The integration of proteolytically degradable polypeptides chain patterns, that is, those identified by metalloproteases secreted matrix by cell, is a common pathway for bio-degradability, which is more in-line and concise newly arranged tissue re-shaping/ regeneration.…”

Section: Enhancing Materials Bio-functionalitymentioning

confidence: 99%

Materials science and design principles of therapeutic materials in orthopedic and bone tissue engineering

Liang

Dong

Shen

et al. 2021

Polymers for Advanced Techs

View full text Add to dashboard Cite

The successful materials design for bone-tissue engineering needs to understand the structure and composition of host bone tissue, and selecting appropriate biomimetic natural or tunable synthetic materials (biomaterials), such as polymers, bioceramics, metals, and composites. Materials that improve bone tissue engineering have tremendous potential for clinical applications to treat and regenerate various bone injuries and fractures. The drive to design bone grafts for bridging the gaps in orthopedic tissue regeneration results in a significant research thrust for designing and developing material for bone tissue regeneration. Recently, numerous challenges, including biomaterial designing, can well suit the biological, chemical and mechanical microenvironment of natural orthopedic tissues and adopt vascularization. Novel bio-inspired materials attempt to enhance the biofunctionality that reconstruct microlevel biofactor and topographical signals from the extracellular environment are rapidly developing. The most important paradigm shift in orthopedic tissue engineering is the careful selection of scaffold, signals, and cell types to design biomaterials. Notwithstanding, the clinical outcome of orthopedic tissue regeneration was so vibrant years ago; however, so far, it failed to achieve the expected results and failed to translate in the clinical setting. In the current review, we discuss the aims and mechanism of bone tissue regeneration, biomaterial designing, and orthopedic tissue engineering requirements. Next, we highlight the principle for orthopedic tissue engineering and describe the strategies for enhancing material Bio-functionality. Finally, we give the bench to bedside concept and concluding remarks with a special focus on future. The main purpose of current paper is to give a comprehensive overview, which is helpful for the researcher to distill this information and design future research strategies for designing materials for orthopedic and bone tissue engineering.

show abstract

Strategies for Bone Regeneration: From Graft to Tissue Engineering

Cited by 159 publications

References 189 publications

Mesoporous bioactive glasses for regenerative medicine

Mesoporous bioactive glasses for regenerative medicine

A Multidisciplinary Journey towards Bone Tissue Engineering

Materials science and design principles of therapeutic materials in orthopedic and bone tissue engineering

Contact Info

Product

Resources

About