Strategies for ensuring required service level for COVID-19 herd immunity in Indian vaccine supply chain

Sinha, Priyank; Kumar, Sameer; Chandra, Charu

doi:10.1016/j.ejor.2021.03.030

Cited by 61 publications

(38 citation statements)

References 57 publications

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“…The vaccine developers had already started incorporating the mutant variants in their vaccines. In addition, the production capacity of the vaccines and vaccine-related supply and logistic support pose important problems [11] . Considering that billions of people will be vaccinated, it seems impossible to meet this huge worldwide demand in a timely manner.…”

Section: Introductionmentioning

confidence: 99%

A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder

Sarohan¹,

Kızıl

İnkaya

et al. 2021

Cellular Signalling

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The SARS-CoV-2 virus has caused a worldwide COVID-19 pandemic. In less than a year and a half, more than 200 million people have been infected and more than four million have died. Despite some improvement in the treatment strategies, no definitive treatment protocol has been developed. The pathogenesis of the disease has not been clearly elucidated yet. A clear understanding of its pathogenesis will help develop effective vaccines and drugs. The immunopathogenesis of COVID-19 is characteristic with acute respiratory distress syndrome and multiorgan involvement with impaired Type I interferon response and hyperinflammation. The destructive systemic effects of COVID-19 cannot be explained simply by the viral tropism through the ACE2 and TMPRSS2 receptors. In addition, the recently identified mutations cannot fully explain the defect in all cases of Type I interferon synthesis. We hypothesize that retinol depletion and resulting impaired retinoid signaling play a central role in the COVID-19 pathogenesis that is characteristic for dysregulated immune system, defect in Type I interferon synthesis, severe inflammatory process, and destructive systemic multiorgan involvement. Viral RNA recognition mechanism through RIG-I receptors can quickly consume a large amount of the body's retinoid reserve, which causes the retinol levels to fall below the normal serum levels. This causes retinoid insufficiency and impaired retinoid signaling, which leads to interruption in Type I interferon synthesis and an excessive inflammation. Therefore, reconstitution of the retinoid signaling may prove to be a valid strategy for management of COVID-19 as well for some other chronic, degenerative, inflammatory, and autoimmune diseases.

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Section: Introductionmentioning

confidence: 99%

A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder

Sarohan¹,

Kızıl

İnkaya

et al. 2021

Cellular Signalling

View full text Add to dashboard Cite

show abstract

“…Such conditions are crucial, particularly for zoonotic infectious diseases (e.g., SARS-CoV-2). Effect of vaccination strategies ( Sinha et al, 2021 ) and incidents of infected after vaccination. No inclusion of recurrent cases (affecting susceptibles); they were included in the SEAIR model.…”

Section: Problem Definitionmentioning

confidence: 99%

A stochastic inventory model of COVID-19 and robust, real-time identification of carriers at large and infection rate via asymptotic laws

Tsiligianni¹,

Tsiligiannis²,

Tsiliyannis³

2023

European Journal of Operational Research

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A critical operations management problem in the ongoing COVID-19 pandemic is cognizance of (a) the number of all carriers at large (CaL) conveying the SARS-CoV-2, including asymptomatic ones and (b) the infection rate (IR). Both are random and unobservable, affecting the spread of the disease, patient arrivals to health care units (HCUs) and the number of victims. A novel, inventory perspective of COVID-19 is proposed, with random inflow, random losses and retrials (recurrent cases) and delayed/distributed exit, with randomly varying fractions of the exit distribution. A minimal construal, it enables representation of COVID-19 evolution with close fit of national incidence profiles, including single and multiple pattern outbreaks, oscillatory, periodic or non-periodic evolution, followed by retraction, leveling off, or strong resurgence. Furthermore, based on asymptotic laws, the minimum number of variables that must be monitored for identifying CaL and IR is determined and a real-time identification method is presented. The method is data-driven, utilizing the entry rate to HCUs and scaled, or dimensionless variables, including the mean residence time of symptomatic carriers in CaL and the mean residence time in CaL of patients entering HCUs. As manifested by several robust case studies of national COVID-19 incidence profiles, it provides efficient identification in real-time under unbiased monitoring error, without relying on any model. The propagation factor, a stochastic process, is reconstructed from the identified trajectories of CaL and IR, enabling evaluation of control measures. The results are useful towards design of policies restricting COVID-19 and encumbrance to HCUs and mitigating economic contraction.

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“… Plasma collection facilities and regional plasma banks have limited capacities The vehicles transporting plasma have a fixed capacity The number of transporting vehicles at each facility and bank is limited There are two types of uncertainty: (a) the uncertainty of plasma demand in each period; and, (b) due to unforeseen conditions, the uncertainty in costs for transporting plasma from the facilities to the plasma banks, and from the plasma banks to the hospitals The location of donor groups and hospitals is fixed The length of each decision period is one day (Milenkovic et al 2015) There are three types of vehicles with different capacities ( Sinha et al 2021 ) The collection costs for plasma include maintenance, testing, and component costs …”

Section: Problem Descriptionmentioning

confidence: 99%

Convalescent plasma bank facility location-allocation problem for COVID-19

Manupati

Schoenherr

Wagner³

et al. 2021

Transportation Research Part E: Logistics and Transportation Re

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Strategies for ensuring required service level for COVID-19 herd immunity in Indian vaccine supply chain

Cited by 61 publications

References 57 publications

A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder

A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder

A stochastic inventory model of COVID-19 and robust, real-time identification of carriers at large and infection rate via asymptotic laws

Convalescent plasma bank facility location-allocation problem for COVID-19

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