Strategies to prevent the occurrence of resistance against antibiotics by using advanced materials

Bassegoda, Arnau; Ivanova, Kristina; Ramon, Eva; Tzanov, Tzanko

doi:10.1007/s00253-018-8776-0

Cited by 82 publications

(66 citation statements)

References 162 publications

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“…Currently, multiple health organizations including the U. S. Centers for Disease Control and Prevention [1], the World Health Organization [2] as well as others [3] have identified proliferation of antimicrobial resistance as a global crisis. Antibiotics are globally used in the treatment of bacterial infections [4][5][6] and typically kill most antibioticsusceptible bacterial populations in a relatively short time. However, a small fraction of bacteria can survive and represent a major concern for emergent antibiotic resistance and recurrent infection [7].…”

Section: Introductionmentioning

confidence: 99%

The effect of antibiotics on the gut microbiome: a metagenomics analysis of microbial shift and gut antibiotic resistance in antibiotic treated mice

Surathu

Raplee

et al. 2020

BMC Genomics

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Background: Emergence of antibiotic resistance is a global public health concern. The relationships between antibiotic use, the gut community composition, normal physiology and metabolism, and individual and public health are still being defined. Shifts in composition of bacteria, antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) after antibiotic treatment are not well-understood. Methods: This project used next-generation sequencing, custom-built metagenomics pipeline and differential abundance analysis to study the effect of antibiotic monotherapy on resistome and taxonomic composition in the gut of Balb/c mice infected with E. coli via transurethral catheterization to investigate the evolution and emergence of antibiotic resistance. Results: There is a longitudinal decrease of gut microbiota diversity after antibiotic treatment. Various ARGs are enriched within the gut microbiota despite an overall reduction of the diversity and total amount of bacteria after antibiotic treatment. Sometimes treatment with a specific class of antibiotics selected for ARGs that resist antibiotics of a completely different class (e.g. treatment of ciprofloxacin or fosfomycin selected for cepA that resists ampicillin). Relative abundance of some MGEs increased substantially after antibiotic treatment (e.g. transposases in the ciprofloxacin group). Conclusions: Antibiotic treatment caused a remarkable reduction in diversity of gut bacterial microbiota but enrichment of certain types of ARGs and MGEs. These results demonstrate an emergence of cross-resistance as well as a profound change in the gut resistome following oral treatment of antibiotics.

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Section: Introductionmentioning

confidence: 99%

The effect of antibiotics on the gut microbiome: a metagenomics analysis of microbial shift and gut antibiotic resistance in antibiotic treated mice

Surathu

Raplee

et al. 2020

BMC Genomics

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“…When enough bacteria are reached, the AIs will enable single bacterium to sense other bacteria in their surroundings and could form biofilms. 46 The formed biofilms exhibit higher virulence and resistance compared to planktonic S. aureus. Oyama et al reported that the thick biofilms of S. aureus showed higher virulence to mice livers than the thin biofilms.…”

Section: S Aureus Biofilmsmentioning

confidence: 99%

A review on nanosystems as an effective approach against infections of <em>Staphylococcus aureus</em>

Zhou¹,

Li²,

Chen³

et al. 2018

IJN

117

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Staphylococcus aureus (S. aureus) is an important zoonotic bacteria and hazardous for the health of human beings and livestock globally. The characteristics like biofilm forming, facultative intracellular survival, and growing resistance of S. aureus pose a great challenge to its use in therapy. Nanoparticles are considered as a promising way to overcome the infections’ therapeutic problems caused by S. aureus. In this paper, the present progress and challenges of nanoparticles in the treatment of S. aureus infection are focused on stepwise. First, the survival and infection mechanism of S. aureus are analyzed. Second, the treatment challenges posed by S. aureus are provided, which is followed by the third step including the advantages of nanoparticles in improving the penetration and accumulation ability of their payload antibiotics into cell, inhibiting S. aureus biofilm formation, and enhancing the antibacterial activity against resistant isolates. Finally, the challenges and future perspective of nanoparticles for S. aureus infection therapy are introduced. This review will help the readers to realize that the nanosystems can effectively fight against the S. aureus infection by inhibiting biofilm formation, enhancing intracellular delivery, and improving activity against methicillin-resistant S. aureus and small colony variant phenotypes as well as aim to help researchers looking for more efficient nano-systems to combat the S. aureus infections.

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“…Covering liposomes by synthesized cationichydrophobic chitosan make them go through cell membrane simply and release curcumin in a controlled manner [38,39]. Although liposomes have great biocompatibility, they suffer from some disadvantages such as curcumin leakage and instability while storage, that causes limitation to use them for drug delivery purposes [40,41].…”

Section: Liposomesmentioning

confidence: 99%

Untitled

Deljoo

Rabiee

2019

Asian J. Nanosci. Mater.

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Extensive studies on curcumin have improved that it has certain therapeutic impact for different kinds of diseases such as cancer. Regardless of its positive features, its application is hampered by its low water solubility, bioavailability, and low cellular uptake. During recent years, several ways have been developed to protect curcumin from degradation and increase the capacity of targeting unhealthy cells. The progress in nanotechnology encouraged nanotechnologists to formulate nanoparticles encapsulating curcumin, such as polymer nanoparticles, solid nanoparticles, liposome/lipid nanoparticles, micelles, dendrimers, polymer conjugates, etc. to enhance sustained release of curcumin at target cells and to improve curcumin bioavailability. Nowadays, newer formulations of nanoparticles as called Hybrid nanoparticles are designed in order to achieve efficient and specific curcumin targeted compound that result in the improved therapeutic efficacy of curcumin with high biocompatibility associated with aptamers, folic acid, chitosan coated halloysite loaded with curcumin-Au hybrid nanoparticle etc. This review describes a number of formulated hybrid nanoparticles and their efficacy in specific targeting to cancerous cells.

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Strategies to prevent the occurrence of resistance against antibiotics by using advanced materials

Cited by 82 publications

References 162 publications

The effect of antibiotics on the gut microbiome: a metagenomics analysis of microbial shift and gut antibiotic resistance in antibiotic treated mice

The effect of antibiotics on the gut microbiome: a metagenomics analysis of microbial shift and gut antibiotic resistance in antibiotic treated mice

A review on nanosystems as an effective approach against infections of <em>Staphylococcus aureus</em>

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