Strategy for early callus induction and identification of anti-snake venom triterpenoids from plant extracts and suspension culture of Euphorbia hirta L.

Samkumar, Amos; Dhanaraj, Premnath; Raj, R.S. David Paul

doi:10.1007/s13205-019-1790-9

Cited by 12 publications

(6 citation statements)

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“…Phytochemical MF a BFE b beta-caryophyllene (Olaoluwa et al,2018); Rautela et al,2020) C 15 H 24 −5.1 farnesol 1 (Rautela et al,2020) C 15 H 26 O −5.2 2,6,10-trimethyltetradecane (Ogunlesi et al,2009) C 17 H 36 −4.3 neophytadiene (Perumal and Mahmud, 2013;Rautela et al,2020) C 20 H 38 −4.6 6,10,14-trimethylpentadecan-2-one (Ogunlesi et al,2009;Perumal and Mahmud, 2013) C 18 H 36 O −5.0 taraxerol acetate (Li et al,2015) C 32 H 52 O 2 −7.5 taraxerone (Ragasa and Cornelio, 2013;Li et al,2015;Tayone et al,2020) C 30 H 48 O −8.0 taraxerol (Perumal and Mahmud, 2013;Prachi and Pradeep, 2014;Li et al,2015;Amos Samkumar et al,2019;Bach et al,2020;Tayone et al,2020) C 30 H 50 O −7.8…”

Section: Idmentioning

confidence: 99%

Phytochemicals of Euphorbia hirta L. and Their Inhibitory Potential Against SARS-CoV-2 Main Protease

Cayona

Creencia

2022

Front. Mol. Biosci.

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Euphorbia hirta L. is a medicinal plant widely used in the Philippines and across tropical Asia against various diseases, including respiratory disorders. In this study, the phytochemical components of E. hirta were investigated in silico for their potential to inhibit the severe acute respiratory syndrome-coronavirus-2 main protease (SARS-CoV-2 Mpro), a coronavirus disease 2019 (COVID-19) drug target that plays a critical role in the infection process of SARS-CoV-2. Phytochemical mining in tandem with virtual screening (PM-VS) was the strategy implemented in this study, which allows efficient preliminary in silico assessment of the COVID-19 therapeutic potential of the reported phytochemicals from the plant. The main rationale for considering E. hirta in the investigation was its reported efficacy against respiratory disorders. It is very promising to investigate the phytochemicals of E. hirta for their potential efficacy against diseases, such as COVID-19, that also target the respiratory system. A total of 298 E. hirta phytochemicals were comprehensively collected from the scientific literature. One hundred seventy of these phytochemicals were computed through molecular docking and were shown to have comparable or better binding properties (promising inhibitors) toward SARS-CoV-2 Mpro than known in vitro inhibitors. In connection to our previous work considering different medicinal plants, antiviral compounds were also rediscovered from the phytochemical composition of E. hirta. This finding provides additional basis for the potential of the plant (or its phytochemicals) as a COVID-19 therapeutic directly targeting drug targets such as SARS-CoV-2 Mpro and/or addressing respiratory-system-related symptoms. The study also highlights the utility of PM-VS, which can be efficiently implemented in the preliminary steps of drug discovery and development.

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Section: Idmentioning

confidence: 99%

Phytochemicals of Euphorbia hirta L. and Their Inhibitory Potential Against SARS-CoV-2 Main Protease

Cayona

Creencia

2022

Front. Mol. Biosci.

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“…Examples of secondary metabolites obtained using suspension cultures can be given as stigmasterol from Abutilon indicum ( Rao et al., 2021 ); gymnemic acids from Gymnema sylvestre ( Mahendran et al., 2021 ); catechin from Camellia sinensis ( Ardianto et al., 2020 ); alkaloids (vincristine, vinblastine, ajmalicine and serpentine) from Catharanthus roseus ( Mishra et al., 2019 ); triterpenoids from Ocimum basilicum ( Pandey et al., 2019 ); artemisinin from Artemisia annua ( Mir et al., 2017 ); plumbagin from Plumbago europaea ( Beigmohamadi et al., 2019 ) and P. zeylanica ( Roy and Bharadvaja, 2019 ); bacoside from Bacopa monnieri ( Kharde et al., 2018 ); hydrolyzable tannin from Phyllanthus debilis ( Malayaman et al., 2017 ); triterpenoids from Euphorbia hirta ( Samkumar et al., 2019 ); atropine from Hyoscyamus muticus ( Abdelazeez et al., 2022 ); triterpenic acids (betulinic acid, oleanolic acid, and ursolic acid) from Thymus persicus (Lamiaceae) ( Bakhtiar and Mirjalili, 2022 ); and withanolides (withaferin A and withanolide A) from Withania coagulans ( Mirjalili and Esmaeili, 2022 ).…”

Section: Tissue Culture-based Biotechnological Approaches For Obtaini...mentioning

confidence: 99%

Production of secondary metabolites using tissue culture-based biotechnological applications

et al. 2023

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Plants are the sources of many bioactive secondary metabolites which are present in plant organs including leaves, stems, roots, and flowers. Although they provide advantages to the plants in many cases, they are not necessary for metabolisms related to growth, development, and reproduction. They are specific to plant species and are precursor substances, which can be modified for generations of various compounds in different plant species. Secondary metabolites are used in many industries, including dye, food processing and cosmetic industries, and in agricultural control as well as being used as pharmaceutical raw materials by humans. For this reason, the demand is high; therefore, they are needed to be obtained in large volumes and the large productions can be achieved using biotechnological methods in addition to production, being done with classical methods. For this, plant biotechnology can be put in action through using different methods. The most important of these methods include tissue culture and gene transfer. The genetically modified plants are agriculturally more productive and are commercially more effective and are valuable tools for industrial and medical purposes as well as being the sources of many secondary metabolites of therapeutic importance. With plant tissue culture applications, which are also the first step in obtaining transgenic plants with having desirable characteristics, it is possible to produce specific secondary metabolites in large-scale through using whole plants or using specific tissues of these plants in laboratory conditions. Currently, many studies are going on this subject, and some of them receiving attention are found to be taken place in plant biotechnology and having promising applications. In this work, particularly benefits of secondary metabolites, and their productions through tissue culture-based biotechnological applications are discussed using literature with presence of current studies.

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“…Different parts of this plant are traditionally used to cure the babies from worm infestations and also prove helpful in dysentery, jaundice, gonorrhea, acne, pimples, digestive orders, diabetes, several types of tumors and in cancers in India 31,32,33,34 . The extracts of the root of E. hirta are used against vomiting, diarrhea and as anti-venum against snakebite 35 . It is also used in the treatment of asthma in South Africa 36 .…”

Section: Medicinal Usesmentioning

confidence: 99%

Untitled

2022

IJPSR

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Euphorbia hirta Linn. (Euphorbiaceae), commonly known as 'Dudhy' is an annual medicinal herb of Kumaun Himalaya Uttarakhand. It is an invasive plant used in conventional medicine to treat various diseases such as gastrointestinal disorders, respiratory system disorders, and asthma. The present review is designed with the aim to compile updated information on E. hirta including its medicinal uses, phytochemicals, as well as biological activities. Qualitative and quantitative phytochemical studies on E. hirta revealed the presence of various chemical compounds in which flavonoids, terpenoids and phenols are the major constituents. These monomeric compounds and crude extracts from E. hirta have also been screened for pharmacological activities in-vivo and in-vitro. Different parts of the plant have interesting antimicrobial, antioxidant, antidiabetic, and antitumor properties. Some traditional uses of this plant, such as in gastrointestinal disorder, bronchitis, and in asthma, also indicated its high medicinal potentiality. E. hirta has been proved a valuable medicinal plant for the tribal people living in the rural region of Kumaun Himalaya. The crude hydro-alcoholic extract of E. hirta has more pharmacological activities. It is used as an important medicinal and nutritional source for curing many severe illnesses in different parts of the world. Therefore, it is the need of the modern time to isolate and identify more bioactive constituents and elucidate their structure, activity and relationship of this plant. It is also emphasized for more detailed research and clinical trials to explore its pharmacological activity and clinical efficacy. INTRODUCTION:Euphorbia hirta Linn. is commonly known as milkweed (Dudhy) and asthma plant. It is known by the different names in different parts of the world 1, 2 . The plant is characterized by the presence of milky white latex which is more or less toxic. Latices of E. ingens, E. tirucalli, E. mey, and E. triangularis are possible sources of rubber 3 .

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Strategy for early callus induction and identification of anti-snake venom triterpenoids from plant extracts and suspension culture of Euphorbia hirta L.

Cited by 12 publications

References 24 publications

Phytochemicals of Euphorbia hirta L. and Their Inhibitory Potential Against SARS-CoV-2 Main Protease

Phytochemicals of Euphorbia hirta L. and Their Inhibitory Potential Against SARS-CoV-2 Main Protease

Production of secondary metabolites using tissue culture-based biotechnological applications

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