Strategy on Persisting in Distinct Activity of Plasmon-Activated Water

Yang, Chih Ping; Tsai, Hui Yen; Tseng, Ching Li; Hao, Pei Jun; Liu, Yu Chuan

doi:10.1021/acsomega.9b02627

Cited by 6 publications

(3 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We first demonstrated the scavenging ability of PAW against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals ( Figure 1 A). The one electron spin resonance (ESR) signal located at 3482 G is characteristic of DPPH radicals [ 17 ]. Compared to the deionized water-based solution, the respective ESR intensity significantly decreased by ca.…”

Section: Resultsmentioning

confidence: 99%

“…This abundance returned to higher levels through PAW consumption. PAW has the notable feature of scavenging free hydroxyl and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals [ 17 , 35 , 36 ]. Now, PAW has emerged with a biomedical potential, including the anti-inflammatory properties [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…ESR spectra were recorded at room temperature using a quartz flat cell designed for solutions. The dead time between sample preparation and ESR analysis was exactly 10 min for experiments in DPPH free radicals [ 17 ] after the last addition. Conditions of ESR spectrometry were as follows: 20 mW of power at 9.78 GHz, with a scan range of 100 G and a receiver gain of 6.32 × 10 4 .…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Functional Plasmon-Activated Water Increases Akkermansia muciniphila Abundance in Gut Microbiota to Ameliorate Inflammatory Bowel Disease

Chang

Liu

et al. 2022

IJMS

Self Cite

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) is associated with dysbiosis and intestinal barrier dysfunction, as indicated by epithelial hyperpermeability and high levels of mucosal-associated bacteria. Changes in gut microbiota may be correlated with IBD pathogenesis. Additionally, microbe-based treatments could mitigate clinical IBD symptoms. Plasmon-activated water (PAW) is known to have an anti-inflammatory potential. In this work, we studied the association between the anti-inflammatory ability of PAW and intestinal microbes, thereby improving IBD treatment. We examined the PAW-induced changes in the colonic immune activity and microbiota of mice by immunohistochemistry and next generation sequencing, determined whether drinking PAW can mitigate IBD induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) and dysbiosis through mice animal models. The effects of specific probiotic species on mice with TNBS-induced IBD were also investigated. Experimental results indicated that PAW could change the local inflammation in the intestinal microenvironment. Moreover, the abundance of Akkermansia spp. was degraded in the TNBS-treated mice but elevated in the PAW-drinking mice. Daily rectal injection of Akkermansia muciniphila, a potential probiotic species in Akkermansia spp., also improved the health of the mice. Correspondingly, both PAW consumption and increasing the intestinal abundance of Akkermansia muciniphila can mitigate IBD in mice. These findings indicate that increasing the abundance of Akkermansia muciniphila in the gut through PAW consumption or other methods may mitigate IBD in mice with clinically significant IBD.

show abstract

Section: Resultsmentioning

confidence: 99%