Stratified enoxaparin dosing achieves prophylactic anti-factor Xa concentration in gastric bypass surgery patients

Comparison of two low-molecular-weight heparin dosing regimens for patients undergoing laparoscopic bariatric surgery

“…In both groups, the mean anti-Xa levels were therapeutic after the third dose. Similar to the study by Borkgren-Okonek et al [8], we found that about 63% of the 40-mg patients and 100% (including supratherapeutic concentrations) of the 60-mg patients achieved at least therapeutic anti-Xa concentrations after the third dose of enoxaparin.…”

“…Enoxaparin regimens of 30, 40, and 60 mg have been studied, and differing conclusions have been drawn [1,2,8]. One study performed by Borkgren-Okonek et al [8] was similar in methodology to the current study except that our study did not stratify patients according to BMI. However, the doses of enoxaparin used, the anti-Xa monitoring technique, and the anti-Xa therapeutic range were similar.…”

“…Finally, Borkgren-Okonek et al [8] explored two different prophylactic enoxaparin regimens (40 vs 60 mg every 12 h) and the corresponding anti-Xa levels. Patients were stratified to groups based on BMI (B50 and [50).…”

Anti-Xa Levels in Bariatric Surgery Patients Receiving Prophylactic Enoxaparin

“…Recently, Borkgren-Okonek et al [7] studied the effects of prophylactic enoxaparin in 68 gastric bypass patients. Patients received a single dose of heparin 5,000 units subcutaneously 2 h before surgery.…”

“…We decided not to base our dosing on BMI. Others utilized BMI-based dosing [7,9]. For example, Paige et al [9] based their dosage on BMI.…”