Undisturbed loess is affected by external environmental disturbances, such as wetting and freeze-thaw cycles, which cause microstructural changes that have an important impact on the structural strength of the loess. These changes in turn affect the stability of structures such as embankments, slopes, and guards. This article takes the Q3 undisturbed loess in Lintong District, Xi’an, as an example. The effects of wetting and freeze-thaw cycles on the loess expansion ratio and pore structure were studied by wetting tests, freeze-thaw cycle tests, and scanning electron microscopy (SEM). The changes in the compression index and compression modulus were studied by a confined compression test. The loess e-lgp compression curve was obtained according to the confined compression test, and the newly defined concepts of the loess structural strength, residual structural strength, and structural strength damage variable, in addition to the e-lgp compression curve, were combined with the experimental data to calculate the damage value generated by the disturbance during the sampling and preparation of loess. The deterioration of the structural strength and damage variable of loess was analyzed. Based on the microscopic statistical damage theory and Weibull distribution, the model used the volume expansion ratio as a variable to establish a statistical damage model under wetting and freeze-thaw cycles. Finally, on the basis of the test, the model parameters were determined. The models were verified by taking loess from a foundation pit in the northern suburbs of Xi’an and were in good agreement with the results of the test. Ultimately, the models have good practicability and can provide guidance for engineering design and construction.