Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE Statement

Abstract

Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modeling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, 123Hum Genet ( ) 125:131-151 DOI 10.1007 statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis.

Biopsychosocial Influence on Shoulder Pain: Influence of Genetic and Psychological Combinations on Twelve‐Month Postoperative Pain and Disability Outcomes

“…This study was reported following STREGA extension 8 of STROBE guidelines 9 and registered prospectively at http://clinicaltrials.gov/ct2/show/NCT00187863. The University of Florida’s Human Subject Institutional Review Board (IRB-01) approved this study and all participants provided informed consent prior to enrollment.…”

Genes and the ageing muscle: a review on genetic association studies

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Interaction between genes and macronutrient intake on the risk of developing type 2 diabetes: systematic review and findings from European Prospective Investigation into Cancer (EPIC)-InterAct

“…Within-study considerations include 1 ) specifying the hypothesis of the study and accounting for multiple testing, as appropriate; 2 ) reporting all interaction results and whether they were analyzed as preplanned or post hoc, regardless of whether findings are positive, negative, or null; and 3 ) ensuring that notable interaction findings are accompanied by independent replication where possible (if this is not feasible, the reasons for and validity of nonreplicated findings should be discussed). General considerations for studies within the field include 1 ) improving consistency and standards in examining and reporting interactions (14, 24, 58), 2 ) conducting studies examining non-European populations, and 3 ) applying isocaloric macronutrient substitution.…”