Strenuous exercise in warm environment is associated with improved microvascular function in sickle cell trait

Reminy, K.; Sock, Émilienne T. Ngo; Romana, Marc; Connes, Philippe; Ravion, Sylvie; Henri, Stéphane; Hue, Olivier; Hardy‐Dessources, Marie‐Dominique; Antoine‐Jonville, Sophie

doi:10.1007/s00421-021-04821-2

Cited by 1 publication

(2 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, in view of the critical role of erythrocyte ENT1 on regulation of plasma levels of adenosine produced in hypoxic conditions, our data might be relevant to the enhanced microvascular reactivity and slight pro-/antioxidant imbalance reported in SCT carriers subjected to maximal exercise in stressful environment. 21 Consistent with results published elsewhere, 13 our work also documents elevated accumulation of polyubiquitinated…”

Section: Discussionsupporting

confidence: 92%

“…Our present finding of a reduced ENT1 expression in erythrocytes from individuals with SCT might be of significance to the model proposed by Archer et al, 20 where sequestration of infected RBCs in the hypoxic microvasculature resulted in HbS polymerisation and impaired P. falciparum parasite growth. Finally, in view of the critical role of erythrocyte ENT1 on regulation of plasma levels of adenosine produced in hypoxic conditions, our data might be relevant to the enhanced microvascular reactivity and slight pro‐/antioxidant imbalance reported in SCT carriers subjected to maximal exercise in stressful environment 21 …”

Section: Discussionmentioning

confidence: 84%

See 1 more Smart Citation

Erythrocyte type 1 equilibrative nucleoside transporter expression in sickle cell disease and sickle cell trait

Koehl

Claude

Reminy³

et al. 2022

Br J Haematol

View full text Add to dashboard Cite

Hypoxia-mediated red blood cell (RBC) sickling is central to the pathophysiology of sickle cell disease (SCD). The signalling nucleoside adenosine is thought to play a significant role in this process. This study investigated expression of the erythrocyte type 1 equilibrative nucleoside transporter (ENT1), a key regulator of plasma adenosine, in adult patients with SCD and carriers of sickle cell trait (SCT). Relative quantitative expression analysis of erythrocyte ENT1 was carried out by Western blot and flow cytometry. Patients with SCD with steady state conditions, either with SS or SC genotype, untreated or under hydroxycarbamide (HC) treatment, exhibited a relatively high variability of erythrocyte ENT1, but with levels not significantly different from normal controls. Most strikingly, expression of erythrocyte ENT1 was found to be significantly decreased in patients with SCD undergoing painful vaso-occlusive episode and, unexpectedly, also in healthy SCT carriers. Promoting hypoxia-induced adenosine signalling, the reduced expression of erythrocyte ENT1 might contribute to the pathophysiology of SCD and to the susceptibility of SCT individuals to altitude hypoxia or exercise to exhaustion.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 84%