Streptococcal bacterial components in cancer therapy

Marzhoseyni, Zeynab; Shojaie, Layla; Tabatabaei, Seyed Alireza; Movahedpour, Ahmad; Safari, Mahmood; Esmaeili, Davoud; Mahjoubin‐Tehran, Maryam; Jalili, Amin; Morshedi, Korosh; Khan, Haroon; Okhravi, Ranaa; Hamblin, Michael R.; Mirzaei, Hamed

doi:10.1038/s41417-021-00308-6

Cited by 20 publications

(12 citation statements)

References 132 publications

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“…Oral streptococci modulate CD4 + CD25 + Foxp3 + regulatory T cells (T reg cells) via a TLR2-mediated NF-κB activation ( 46 ) and despite an exhaustive comprehension of the role of these cell subsets in oropharyngeal cancers is still far to be fully accomplished ( 47 ), some intriguing speculative hypothesis, can be put forward, at least on the basis of the unexpected and paradoxical protective role of some streptococcal strains on the cancer etiology in the oral microenvironment ( 48 , 49 ).…”

Section: Does the Immune Microenvironment Plays A Role?mentioning

confidence: 99%

“…One of the leading species modulating Foxp3 Treg cells in oral mucosa is Streptococcus gordonii , which usually disappears in laryngeal oral tumors to be replaced by other streptococcal species ( 33 , 46 ). It is arguable that the Streptococcus genus, highly represented within the oral microbiome, may play a major role in maintaining the microbial homeostasis in the oral cavity by attenuating the immune response via the upregulation of Foxp3 + T reg cells ( 48 ). The participation of the Streptococcus genus to the aforementioned immune homeostasis occurs because this bacterial phylotype colonizes prevalently the oral mucosa as compared with other strains ( 51 ).…”

Section: Does the Immune Microenvironment Plays A Role?mentioning

confidence: 99%

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Oral microbiota in oropharyngeal cancers: Friend or foe?

Nocini

Muzio²,

Gibellini³

et al. 2022

Front. Oncol.

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Oral microbiome is a complex population of micro-organisms, which by cross-talking with the local immune system, plays a major role in the immune homeostasis of the oral cavity, further contributing in the physiology of the gastro-intestinal microbiota. Understanding their involvement in the onset and pathogenesis of oropharyngeal cancers is paramount, despite very few reports deal with the fundamental role exerted by oral microbiota disorders, such as dysbiosis and impairment in the oral microbiome composition as causative factors in the development of oropharyngeal tumors. Current research, via metabolomic or meta-transcriptomic analyses, is wondering how this complex microbial population regulates the immune homeostasis in oral and pharyngeal mucosa and whether changes in bacterial composition may give insights on the role of oral microbiome in the development of oropharyngeal tumors, so to prevent their occurrence.

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Section: Does the Immune Microenvironment Plays A Role?mentioning

confidence: 99%

Section: Does the Immune Microenvironment Plays A Role?mentioning

confidence: 99%

Oral microbiota in oropharyngeal cancers: Friend or foe?

Nocini

Muzio²,

Gibellini³

et al. 2022

Front. Oncol.

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“…The microbial contamination of medical equipment caused by bacterial or fungal pathogens is an important factor in the transmission of nosocomial infections ( Francolini et al, 2015 ; Abed et al, 2022 ; Panahi et al, 2011 ; Rashki et al, 2021a ; Marzhoseyni et al, 2022 ; Mirzaei et al, 2020 ). Moreover, the alarming rise in antimicrobial-resistant species caused by the overuse of antibiotics now poses serious health and economic threat worldwide ( Marcello et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid-Based Nanomaterials as a New Approach to the Treatment and Prevention of Bacterial Infections

Alipoor

Ayan²,

Hamblin

et al. 2022

Front. Bioeng. Biotechnol.

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Bacterial contamination of medical devices is a great concern for public health and an increasing risk for hospital-acquired infections. The ongoing increase in antibiotic-resistant bacterial strains highlights the urgent need to find new effective alternatives to antibiotics. Hyaluronic acid (HA) is a valuable polymer in biomedical applications, partly due to its bactericidal effects on different platforms such as contact lenses, cleaning solutions, wound dressings, cosmetic formulations, etc. Because the pure form of HA is rapidly hydrolyzed, nanotechnology-based approaches have been investigated to improve its clinical utility. Moreover, a combination of HA with other bactericidal molecules could improve the antibacterial effects on drug-resistant bacterial strains, and improve the management of hard-to-heal wound infections. This review summarizes the structure, production, and properties of HA, and its various platforms as a carrier in drug delivery. Herein, we discuss recent works on numerous types of HA-based nanoparticles to overcome the limitations of traditional antibiotics in the treatment of bacterial infections. Advances in the fabrication of controlled release of antimicrobial agents from HA-based nanosystems can allow the complete eradication of pathogenic microorganisms.

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“…Currently, new therapeutic strategies,such as bacterial therapy, boron neutron capture therapy and targeted non-coding RNA (ncRNA) are under development and may be the treatment options for cancer in the future. 3,4 In recent years, ncRNAs have become a popular topic in many researches. 5 They result from the pervasive transcription of the mammalian genome, 6 as the name suggests, and do not code for proteins.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Emerging Role of Circ-SHPRH in Cancer

Tang

et al. 2021

OTT

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Purpose: Circ-SHPRH is a circular RNA that can regulate the expression of target genes by sponging microRNAs (miRNAs) or translating tumor suppressor proteins. Recent studies have suggested that circ-SHPRH may play a role in the development of tumors and cancers. Hence, this paper aimed to review the biological characteristics, molecular mechanisms, and potential clinical significance of circ-SHPRH in a variety of tumors and to evaluate its potential as a new diagnostic and prognostic biomarker. Methods: Numerous experiments were performed regarding the abnormal expression of circ-SHPRH in a variety of tumors, including hepatocellular carcinoma, gastric carcinoma, non-small cell lung cancer, osteosarcoma, colorectal cancer, cholangiocarcinoma, pancreatic ductal adenocarcinoma, retinoblastoma, and glioblastoma. Results: Upregulation of circ-SHPRH reportedly inhibits tumor cell proliferation, migration, and invasion, leading to the inhibition of tumor development. The clinicopathological parameters and the functional characteristics of circ-SHPRH in multiple human tumors and cancers were summarized. Circ-SHPRH functions as a tumor suppressor gene and has great potential as a diagnostic and prognostic biomarker for different types of cancer.

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Streptococcal bacterial components in cancer therapy

Cited by 20 publications

References 132 publications

Oral microbiota in oropharyngeal cancers: Friend or foe?

Oral microbiota in oropharyngeal cancers: Friend or foe?

Hyaluronic Acid-Based Nanomaterials as a New Approach to the Treatment and Prevention of Bacterial Infections

The Emerging Role of Circ-SHPRH in Cancer

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