Streptococcal tonsillitis as a cause of urticaria

Calado, G; Loureiro, Graça; Machado, Daniel; Tavares, Beatriz; Ribeiro, Carmelita; Pereira, Celso; Luís, Ana R.

doi:10.1016/j.aller.2011.06.008

Cited by 11 publications

(8 citation statements)

References 15 publications

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“…Allergens and additives are commonly identified triggers. Infectious triggers such as pyogenic bacterial infections and helicobacter pylori have also been described [12,13]. Additionally, physical triggers including pressure, heat, cold, exercise are well established causes of urticaria [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Intravenous Immunoglobulin as a Potential Therapy for Refractory Urticaria - A Review

Watkins¹,

Peiris²,

Saleh³

et al. 2012

IADT

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Urticaria can be a chronic and debilitating affliction and is a relatively common disorder affecting between 10- 20% of the population. Common causes include reactions to medication, food allergen, physical stimuli and venoms. Urticaria can be acute or chronic. Chronic urticaria lasts for more than 6 weeks and is commonly difficult to treat. The use of immunosuppressive agents for this disorder when antihistamines fail can result in significant morbidity. Recent advances in the pathogenesis, etiology, diagnosis and management of chronic urticaria have led to new paradigms in treatment of this disorder. Cyclosporine is often the most effective but has some unique adverse effects that may prevent it from being used in some patients. The use of intravenous immunoglobulin (IVIG) has proven effective in a variety of reports and we will review the mechanisms likely involved in the successful control of urticarial symptoms by immunomodulating therapy using IVIG. In this review, we will discuss mechanisms and pathogenesis of urticaria and the specific role of intravenous immunoglobulin (IVIG) in this disorder, especially in refractory or steroid-dependent cases.

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Section: Discussionmentioning

confidence: 99%

Intravenous Immunoglobulin as a Potential Therapy for Refractory Urticaria - A Review

Watkins¹,

Peiris²,

Saleh³

et al. 2012

IADT

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“…[15][16][17][18][19][20][21] Antistreptococcal antibodies have been described in 10 -42% of patients with CU. 6 In 1964 antistreptolysin titers were reported significantly more common in acute urticaria (AU) compared with controls.…”

Section: Streptococcus Sppmentioning

confidence: 99%

“…19 All patients denied a clinical relationship between urticaria and underling infections at the first consultation. Later, 71.4% of patients recognized that urticaria exacerbations were coincident with tonsillitis.…”

Section: Streptococcus Sppmentioning

confidence: 99%

Urticaria and bacterial infections

Minciullo

Barberi²,

Gangemi³

2014

allergy asthma proc

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The association between urticaria and infectious diseases has been discussed for >100 years. However, a causal relationship with underlying or precipitating infection is difficult to establish. The purpose of this work was to perform a systematic analysis of the published cases of urticaria associated with bacterial infections. We give an umbrella breakdown of up-to-date systematic reviews and other important publications on the complex association of urticaria and bacterial infections. We did a Medline search, for English language articles published until January 2014, using the key words "urticaria" and "bacteria/bacterial disease"; a second analysis was performed in groups of bacteria and using each germ name as a key word. Many bacterial infections have been associated with urticaria manifestation, such as Helicobacter pylori, Streptococcus, Staphylococcus, Mycoplasma pneumonia, Salmonella, Brucella, Mycobacterium leprae, Borrelia, Chlamydia pneumonia, and Yersinia enterocolitica. In some cases the skin manifestations, described as urticaria, could be caused by the presence of the microorganism in the skin, or for the action of their toxins, or to the complement activation mediated by circulating immune complexes. Although only a weak association with urticaria of unclear pathogenesis exists, clinicians should consider these bacterial agents in the workup of the patients with urticaria. The eradication of the infection could, in fact, lead to the resolution of urticaria. Prospective studies and well-structured research are obviously needed to better clarify the real role of bacteria in the pathogenesis of urticaria and their relative prevalence.

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“…В детском возрасте установлена более частая хронизация крапивницы при на-личии сопутствующих инфекций, которые так-же рассматриваются и как триггеры обострений [59]. Их выявляемость достигает 35% среди детей с данной патологией [76] Наиболее часто выявляемыми инфекциями у детей, страдающих хронической крапивницей, являются инфекции урогенитального тракта, вы-званные Е. соli [15], дыхательных путей, обуслов-ленные С. pneumoniae, Streptococcus pyogenes [25], вирусные заболевания, такие как инфекционный мононуклеоз ВЭБ-этиологии и цитомегалови-русная инфекция [61], хеликобактерная инфек-ция [7], паразитарные инвазии [1].…”

Section: иммунопатология хронической крапивницы у детейunclassified

“…При хронической крапивнице у детей антигенная мимикрия опи-сана при инфицировании Helicobacter pylori (40-90%), Yersinia enterocolitica (31-39%), Streptococcus pyogenes [17,25].…”

Section: иммунопатология хронической крапивницы у детейunclassified

Chronic Urticarial in Childhood. Immune Pathology of Chronic Urticarial in Children (Part I)

2014

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Резюме. В данной части обзора рассмотрены распространенность, генетические факторы пред-расположенности и некоторые иммунологические механизмы хронической крапивницы у детей. Показано, что тучным клеткам и базофилам принадлежит центральная роль в патогенезе всех форм. В ходе воспалительных реакций при хроническом течении крапивницы происходит стимуляция про-дукции таких цитокинов, как CCL2, CХCL8, IL-1, IL-4, IL-6, IL-10, IL-13, IL-17. Активация туч-ных клеток и базофилов реализуется через специфические рецепторы на мембране клеток. Особое место занимает аутоиммунная крапивница, в патогенезе которой участвуют анти-FCεRIα антитела или аутоантитела к IgE, оказывающие гистамино-высвобождающее действие за счет перекрестного связывания α-цепей высокоаффинного IgE рецептора или перекрестного связывания фиксирован-ных на тучных клетках IgE. Дегрануляция базофилов сопровождается появлением активационных молекул -СD203с, CD63. Экспрессию СD203с ряд авторов считает косвенным признаком аутоим-мунного процесса, при наличии положительного теста с аутосывороткой. Повышение экспрессии лиганда CD40L на поверхности активированных Т-лимфоцитов свидетельствует об усилении сигна-лов для активации В-лимфоцитов и синтеза аутоантител.Ключевые слова: хроническая крапивница, цитокины, базофилы, CD203c

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Streptococcal tonsillitis as a cause of urticaria

Abstract: Our study encourages the investigation of tonsillitis in these otherwise idiopathic patients, especially until young adulthood and even in the absence of any symptoms.

Cited by 11 publications

References 15 publications

Intravenous Immunoglobulin as a Potential Therapy for Refractory Urticaria - A Review

Intravenous Immunoglobulin as a Potential Therapy for Refractory Urticaria - A Review

Urticaria and bacterial infections

Chronic Urticarial in Childhood. Immune Pathology of Chronic Urticarial in Children (Part I)

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