Streptococcus agalactiae em gestantes: prevalência de colonização e avaliação da suscetibilidade aos antimicrobianos

Borger, Irina Lermontov; d'Oliveira, Rachel E.C.; Castro, Angela C. D.; Mondino, Silvia Susana Bona de

doi:10.1590/s0100-72032005001000002

Cited by 19 publications

(30 citation statements)

References 19 publications

(16 reference statements)

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“…This worldwide variability is related to different sociocultural, geographic, climatic, biological and methodological determinants. Brazilian studies have found rates ranging from 5 to 25% (3,5,22,23,26,29,30). Our finding of a 32.6% rate of GBS prevalence using the genetic detection directly from the enrichment culture is worrisome and the highest reported in the country to our knowledge so far.…”

Section: Discussionmentioning

confidence: 99%

“…As the culture-PCR based method, in our study, showed higher GBS detection rates, and two genetic markers were targeted, we believe that Although vancomycin is not a first line drug for prophylaxis of perinatal streptococcal disease, some enterococci and Staphylococcus aureus (28) isolates have been proving resistant to this antibiotic. This trend notwithstanding, no vancomycin-resistant GBS isolates have been identified (2,5,10,24,28). In the light of the findings, vancomycin may be considered a better option for prophylaxis of patients allergic to penicillin.…”

Section: Discussionmentioning

confidence: 99%

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Detection of Group B Streptococcus in Brazilian pregnant women and antimicrobial susceptibility patterns

Castellano-Filho¹,

Silva²,

Nascimento³

et al. 2010

Braz. J. Microbiol.

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Group B Streptococcus (GBS) is still not routinely screened during pregnancy in Brazil, being prophylaxis and empirical treatment based on identification of risk groups. This study aimed to investigate GBS prevalence in Brazilian pregnant women by culture or polymerase chain reaction (PCR) associated to the enrichment culture, and to determine the antimicrobial susceptibility patterns of isolated bacteria, so as to support public health policies and empirical prophylaxis. After an epidemiological survey, vaginal and anorectal specimens were collected from 221 consenting laboring women. Each sample was submitted to enrichment culture and sheep blood agar was used to isolate suggestive GBS. Alternatively, specific PCR was performed from enrichment cultures. Antimicrobial susceptibility patterns were determined for isolated bacteria by agar diffusion method. No risk groups were identified. Considering the culture-based methodology, GBS was detected in 9.5% of the donors. Twenty five bacterial strains were isolated and identified. Through the culture-PCR methodology, GBS was detected in 32.6% specimens. Bacterial resistance was not detected against ampicillin, cephazolin, vancomycin and ciprofloxacin, whereas 22.7% were resistant to erythromycin and 50% were resistant to clindamycin. GBS detection may be improved by the association of PCR and enrichment culture. Considering that colony selection in agar plates may be laboring and technician-dependent, it may not reflect the real prevalence of streptococci. As in Brazil prevention strategies to reduce the GBS associated diseases have not been adopted, prospective studies are needed to anchor public health policies especially considering the regional GBS antimicrobial susceptibility patterns.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Detection of Group B Streptococcus in Brazilian pregnant women and antimicrobial susceptibility patterns

Castellano-Filho¹,

Silva²,

Nascimento³

et al. 2010

Braz. J. Microbiol.

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“…19 In Rio de Janeiro prevalence rates of 19.2% were found from 2003 to 2004. 20 A study accomplished at the Center for Integral Attention to Women's Health at the University of Campinas in 2003 and 2004 found the rate ofmaternal GBS colonization of 27.6%. 6 In São Luis -Maranhão, the prevalence was 20.4% from 2005 to 2006.…”

Section: Discussionmentioning

confidence: 99%

“…Erythromycin and clindamycin are the drugs of choice for prophylaxis in women colonized by GBS who are allergic to penicillin. 1 Although most strains are susceptible to penicillin, 14,15,20,23,24 the increased use of erythromycin and clindamycin in patients allergic to penicillin or for the prevention and treatment ofother infections, has shown growth rates of GBS resistance to these antimicrobial agents in many countries, including Brazil. 15,20 A study made from 1994 to 1999 in Rio de Janeiro found in colonized women 5.4% and 1.1% of GBS resistance to erythromycin and clindamycin, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…1 Although most strains are susceptible to penicillin, 14,15,20,23,24 the increased use of erythromycin and clindamycin in patients allergic to penicillin or for the prevention and treatment ofother infections, has shown growth rates of GBS resistance to these antimicrobial agents in many countries, including Brazil. 15,20 A study made from 1994 to 1999 in Rio de Janeiro found in colonized women 5.4% and 1.1% of GBS resistance to erythromycin and clindamycin, respectively. 25 15 In relation to susceptibility of four pregnant women colonized by GBS in the present study, we found no resistance to the tested antimicrobials.…”

Section: Discussionmentioning

confidence: 99%

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<b> COLONIZATION PREVALENCE AND SUSCEPTIBILITY OF Streptococcus agalactiae IN PREGNANT WOMEN AT HUSM </b>

et al. 2011

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The Streptococcus agalactiae colonization prevalence and its susceptibility to antimicrobials in pregnant women at University Hospital of Santa Maria (HUSM) were evaluated from June to December 2009. The vaginal-rectal material was inoculated into tubes containing Todd-Hewitt broth with subsequent subculture on blood agar. The GBS identification was made through presumptive tests, confirmed by serological test and its susceptibility was evaluated. The occurrence ofGBS maternal-fetal transmission in the colonized pregnant women was researched. The GBS colonization was 11.11%. All strains were susceptible to penicillin, ampicillin, and vancomycin. Two strains (50%) were intermediate to clindamycin and one (25%) intermediate to erythromycin. A newborn whose mother was colonized had early-onset neonatal infection by GBS. By this, it is very important the research about the colonization by GBS in all pregnant women from 35 to 37 weeks of gestation and the use of intrapartum antibiotic prophylaxis for colonized pregnant women.Descriptors: Streptococcus agalactiae; Prevalence; Pregnant women; Newborns; Microbial Sensitivity Tests. RESUMOAvaliou-se a prevalência de colonização pelo Streptococcus agalactiae e o seu perfil de sensibilidade frente aos antimicrobianos em gestantes no Hospital Universitário de Santa Maria (HUSM), de junho a dezembro de 2009. O material vaginal-retal foi inoculado em tubos contendo caldo Todd-Hewitt com posterior subcultura em ágar sangue. A identificação do EGB foi realizada através de testes presuntivos, confirmadas por teste sorológico e avaliado seu perfil de sensibilidade. Pesquisou-se ocorrência de transmissão materno-fetal do EGB nas gestantes colonizadas. A prevalência de colonização foi de 11,11%. Todas as cepas foram sensíveis à penicilina, ampicilina e vancomicina. Duas cepas (50%) foram intermediárias à clindamicina e uma (25%) intermediária à eritromicina. Um recém-nascido de mãe colonizada teve infecção neonatal de início precoce por EGB. Confirma-se a importância da pesquisa de colonização por EGB em todas as gestantes entre 35ª e 37ª semana de gestação e uso de quimioprofilaxia intraparto nas gestantes colonizadas.

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Assessment of conventional PCR and real-time PCR compared to the gold standard method for screening Streptococcus agalactiae in pregnant women

Ferreira

de‐Paris

Paiva

et al. 2018

The Brazilian Journal of Infectious Diseases

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Streptococcus agalactiae em gestantes: prevalência de colonização e avaliação da suscetibilidade aos antimicrobianos

Cited by 19 publications

References 19 publications

Detection of Group B Streptococcus in Brazilian pregnant women and antimicrobial susceptibility patterns

Detection of Group B Streptococcus in Brazilian pregnant women and antimicrobial susceptibility patterns

<b> COLONIZATION PREVALENCE AND SUSCEPTIBILITY OF Streptococcus agalactiae IN PREGNANT WOMEN AT HUSM </b>

Assessment of conventional PCR and real-time PCR compared to the gold standard method for screening Streptococcus agalactiae in pregnant women

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