Streptococcus bovis Endophthalmitis: A Unique Presentation of Colon Cancer

Bleibel, Wissam; D’Silva, Karl J.; Elhorr, Ali; Bleibel, Samer; Dhanjal, Upandra

doi:10.1007/s10620-006-9287-x

Cited by 18 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…gallolyticus subsp. gallolyticus causes other diseases associated with collagen exposure, such as spondylodiscitis, knee arthroplasty and endophthalmitis [ 16 – 19 ]. Vollmer et al and Sillanpää et al revealed that S .…”

Section: Introductionmentioning

confidence: 99%

Biofilm formation and transcriptome analysis of Streptococcus gallolyticus subsp. gallolyticus in response to lysozyme

et al. 2018

View full text Add to dashboard Cite

Streptococcus gallolyticus subsp. gallolyticus is a commensal bacterium of the human gastrointestinal tract, and a pathogen causing infective endocarditis and other biofilm-associated infections via exposed collagen. This study focuses on the characterization of the biofilm formation and collagen adhesion of S. gallolyticus subsp. gallolyticus under different conditions. In this study, it has been observed that the isolate UCN 34 is resistant to 20 mg/ ml lysozyme in BHI medium, whereas the strain BAA-2069 builds more biofilm in the presence of lysozyme compared to in a control of BHI without lysozyme. A transcriptome analysis with whole genome microarrays of these two isolates in BHI medium with lysozyme compared to control without lysozyme revealed changes in gene expression levels. In the isolate BAA-2069, 67 genes showed increased expression in the presence of lysozyme, while in the isolate UCN 34, 165 genes showed increased expression and 30 genes showed decreased expression through lysozyme treatment. Products of genes which were higher expressed are in involved in transcription and translation, in cell-wall modification, in hydrogen peroxide resistance and in bacterial immunity. Furthermore, the adhesion ability of different strains of S. gallolyticus subsp. gallolyticus to collagen type I and IV was analyzed. Thereby, we compared the adhesion of 46 human isolates with 23 isolates from animals. It was shown that the adhesion ability depends significantly on whether the isolate was isolated from human or animal. For example, high adhesion ability was observed for strain UCN 34 isolated from an infective endocarditis patient, whereas strain DSM 16831 isolated from koala feces adhered only marginally to collagen. Full genome microarray analysis of these two strains revealed strain-dependent gene expression due to adhesion. The expression of 25 genes of a transposon and 15 genes of a phage region in strain DSM 16831 were increased, which corresponds to horizontal gene transfer. Adherence to collagen in strain UCN 34 led to higher expression of 27 genes and lower expression of 31 genes. This was suggestive of a change in nutrient uptake.

show abstract

Section: Introductionmentioning

confidence: 99%

Biofilm formation and transcriptome analysis of Streptococcus gallolyticus subsp. gallolyticus in response to lysozyme

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Its association with gastrointestinal disorders like peptic ulcer disease, inflammatory bowel disease and malignancy has been widely evaluated, and S. bovis infection in colorectal carcinoma is well established 8. Colonic malignancy has been diagnosed in patients who presented with endophthalmitis and S. bovis bacteraemia9 and S. bovis -related septic arthritis 10 . S. bovis -related endocarditis usually presents with an indolent course and tends to occur in older men with underlying colonic pathology 11 .…”

Section: Discussionmentioning

confidence: 99%

Streptococcus gallolyticus-related spinal epidural abscess

et al. 2022

View full text Add to dashboard Cite

Spinal epidural abscess (SEA) is a surgical emergency if it causes paraplegia. Staphylococcus aureus and streptococci are the most common causes. Streptococcus gallolyticus has been reported to cause SEA only on three occasions earlier—all were associated with endocarditis or colonic malignancy. We report an older woman with diabetic ketoacidosis who presented with poorly localised back pain, fever and altered sensorium. Her lumbar puncture revealed frank pus, and MRI showed an SEA. She could not be weaned from mechanical ventilation post-surgical decompression, and she succumbed to ventilator-associated pneumonia. A triad of fever, back pain and neurological deficit should lead one to consider intraspinal suppuration. This report is the first S. gallolyticus-related SEA from India and the first in literature that was not associated with either endocarditis or colonic malignancy.

show abstract

“…It is the patho-gen agent of bacteremia, endocarditis, and other unusual infections, including endophtalmitis and arthritis. 8,9 However, S. bovis is not a common cause of bacteremia in hemodialysis patients. The relationship between S. bovis bacteremia and colorectal carcinoma has been previously well documented.…”

Section: Discussionmentioning

confidence: 99%

Streptococcus bovis bacteremia related to colon adenoma in a chronic hemodialysis patient

Kahveci¹,

Arı²,

Arıkan³

et al. 2010

Hemodialysis International

View full text Add to dashboard Cite

We report the case of a 54-year-old hemodialysis patient who presented with recurrent fever due to Streptococcus bovis bacteremia related to colonic tubulovillous adenoma. Following polypectomy and broad-spectrum antibiotic therapy, the patient totally recovered. In this paper, we discussed the relation between S. bovis bacteremia, colonic adenomas, and hemodialysis. Awareness of this association is critical for early diagnosis and management.

show abstract

Streptococcus bovis Endophthalmitis: A Unique Presentation of Colon Cancer

Cited by 18 publications

References 17 publications

Biofilm formation and transcriptome analysis of Streptococcus gallolyticus subsp. gallolyticus in response to lysozyme

Biofilm formation and transcriptome analysis of Streptococcus gallolyticus subsp. gallolyticus in response to lysozyme

Streptococcus gallolyticus-related spinal epidural abscess

Streptococcus bovis bacteremia related to colon adenoma in a chronic hemodialysis patient

Contact Info

Product

Resources

About