Key Clinical MessageStreptococcus gordonii‐associated endocarditis is a rare occurrence, raising diagnostic challenges, and is often associated with considerable morbidity. However, vigilance can prevent devastating consequences.AbstractStreptococcus gordonii‐associated endocarditis is rarely reported but often associated with considerable morbidity. We describe three cases of infective endocarditis caused by S. gordonii during a four‐week period in 2023, and the use of whole‐genome sequencing to determine whether these isolates were genetically related. The available literature was reviewed.