Streptococcus pneumoniae Genome Database (SPGDB): A database for strain specific comparative analysis of Streptococcus pneumoniae genes and proteins

Abstract

Streptococcus pneumoniae causes pneumonia, septicemia and meningitis. S. pneumoniae is responsible for significant mortality both in children and in the elderly. In recent years, the whole genome sequencing of various S. pneumoniae strains have increased manifold and there is an urgent need to provide organism specific annotations to the scientific community. This prompted us to develop the Streptococcus pneumoniae Genome Database (SPGDB) to integrate and analyze the completely sequenced and available S. pneumoniae genome sequences. Further, links to several tools are provided to compare the pool of gene and protein sequences, and proteins structure across different strains of S. pneumoniae. SPGDB aids in the analysis of phenotypic variations as well as to perform extensive genomics and evolutionary studies with reference to S. pneumoniae. The database will be updated at regular intervals and is freely accessible through the URL: http://pranag.physics.iisc.ernet.in/SPGDB/.

Deep genome annotation of the opportunistic human pathogen Streptococcus pneumoniae D39

“…Ceaseless technological advances have revolutionized our capability to determine genome sequences as well as our ability to identify and annotate functional elements, including transcriptional units on these genomes. Several resources have been developed to organize current knowledge on the important opportunistic human pathogen Streptococcus pneumoniae , or the pneumococcus ( 1–3 ). However, an accurate genome map with an up-to-date and extensively curated genome annotation, is missing.…”

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Deep genome annotation of the opportunistic human pathogenStreptococcus pneumoniaeD39

“…Ceaseless technological advances have revolutionized our capability to determine genome sequences as well as our ability to identify and annotate functional elements, including transcriptional units on these genomes. Several resources have been developed to organize current knowledge on the important opportunistic human pathogen Streptococcus pneumoniae, or the pneumococcus (1)(2)(3). However, an accurate genome map with an up-to-date and extensively curated genome annotation, is missing.…”