Streptococcus Pneumoniæ in Chronic Bronchitis

Kilbourn, J.P.

doi:10.1016/s0140-6736(73)91662-0

Cited by 2 publications

(3 citation statements)

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“…As stated previously, a blunted antibody response to pneumococcal colonization also may be attributed to chronic antibiotic and, in particular, anti-staphylococcal therapy. 11,12 During the period of data collection, approx- imately 90% of our CF patients were receiving such therapy (A. Colin, personal communication). For these reasons, we anticipated a blunted response to pneumococcus in our CF population.…”

Section: Discussionmentioning

confidence: 99%

“…This action may eradicate organisms before an antibody response can be generated. 11 The abnormal airway secretions in CF and overgrowth of the respiratory epithelium by other organisms, such as P aeruginosa, also may impair the ability to recognize and mount an appropriate antibody response to pneumococcus. Indeed, Burns and May 12 reported a decreased incidence of precipitating antibodies to pneumococcus in patients with CF compared with those with chronic bronchitis and control subjects.…”

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confidence: 99%

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Preimmunization Anti-Pneumococcal Antibody Levels Are Protective in a Majority of Patients With Cystic Fibrosis

Lahiri

Waltz

2001

Pediatrics

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ABSTRACT. Objective. Although invasive pneumococcal disease is infrequent in cystic fibrosis (CF), it is recommended that all patients with CF receive pneumococcal immunization. As part of a comprehensive program to immunize our clinic population, we obtained preimmunization anti-pneumococcal antibody levels. We hypothesized that the percentage of CF patients without protective levels of anti-pneumococcal antibody levels would be high, as they are exposed to frequent antibiotic therapy that may eradicate organisms before generation of an antibody response.Methods. An observational study of 100 patients with CF, aged 1 to 39 years, was conducted in a regional CF center. Preimmunization anti-pneumococcal antibody levels against 6 serotypes were measured by enzymelinked immunosorbent assay. Protective antibody levels were defined as >200 ng/mL.Results. A majority of CF patients-61% to 100%, depending on age and serotype-had protective levels of pneumococcal antibody. There was a significant positive correlation between antibody level and age for 5 of the 6 serotypes tested.Conclusions. In contradistinction to our hypothesis, the majority of CF patients have protective preimmunization anti-pneumococcal antibody levels. However, a significant proportion-between 17% and 39%, depending on the serotype-did not exhibit adequate levels. Therefore, we concur with current recommendations for pneumococcal immunization in CF. Pediatrics 2001; 108(4). URL: http://www.pediatrics.org/cgi/content/full/ 108/4/e62; cystic fibrosis, Streptococcus pneumoniae, immunization, ELISA.ABBREVIATIONS. CF, cystic fibrosis; ELISA, enzyme-linked immunosorbent assay; RIA, radioimmunoassay.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Preimmunization Anti-Pneumococcal Antibody Levels Are Protective in a Majority of Patients With Cystic Fibrosis

Lahiri

Waltz

2001

Pediatrics

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“…Earlier, it was reported that the sputum bacterial flora of patients seen at the Veterans Administration Hospital, Portland, OR was different from that of patients with cystic fibrosis (6)(7)(8).…”

Section: Sirmentioning

confidence: 99%

Letter to the Editor: Bacterial Flora and Ion Content of Cystic Fibrosis Sputum

Kilbourn¹

1980

Pediatr Res

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Streptococcus Pneumoniæ in Chronic Bronchitis

Cited by 2 publications

References 9 publications

Preimmunization Anti-Pneumococcal Antibody Levels Are Protective in a Majority of Patients With Cystic Fibrosis

Preimmunization Anti-Pneumococcal Antibody Levels Are Protective in a Majority of Patients With Cystic Fibrosis

Letter to the Editor: Bacterial Flora and Ion Content of Cystic Fibrosis Sputum

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