Streptococcuspneumoniae : absence d'émergence de résistance à la pristinamycine

Weber, Philippe

doi:10.1016/s0369-8114(01)00255-3

Cited by 9 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17 Pristinamycin I is used as an alternative to rifampicin, fusidic acid or linezolid in the treatment of methicillin-resistant Staphylococcus aureus MRSA, drug-resistant Streptococcus pneumoniae and vancomycin-resistant Enterococcus faecium as well as some Gram-negative bacteria, such as Haemophilus spp. 17,[49][50][51][52] In addition to the monocyclic peptides mentioned above, a bicyclic peptide named dityromycin is also a Phg-containing peptide (Scheme 3). 53,54 Dityromycin is produced by Streptomyces sp.…”

Section: Phg-containing Peptidesmentioning

confidence: 99%

Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products

et al. 2015

View full text Add to dashboard Cite

Phenylglycine-type amino acids occur in a wide variety of peptide natural products, including glycopeptide antibiotics and biologically active linear and cyclic peptides. Sequencing of biosynthesis gene clusters of chloroeremomycin, balhimycin and pristinamycin paved the way for intensive investigations on the biosynthesis of 4-hydroxyphenylglycine (Hpg), 3,5-dihydroxyphenylglycine (Dpg) and phenylglycine (Phg) in recent years. The significance and importance of this type of unusual non-proteinogenic aromatic amino acids also for medicinal chemistry has drawn the attention of many research groups and pharmaceutical companies. Herein structures and properties of phenylglycine containing natural products as well as the biosynthetic origin and incorporation of phenylglycines are discussed.

show abstract