2018
DOI: 10.3389/fendo.2018.00003
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Stress and Corticosteroids Aggravate Morphological Changes in the Dentate Gyrus after Early-Life Experimental Febrile Seizures in Mice

Abstract: Stress is the most frequently self-reported seizure precipitant in patients with epilepsy. Moreover, a relation between ear stress and epilepsy has been suggested. Although ear stress and stress hormones are known to influence seizure threshold in rodents, effects on the development of epilepsy (epileptogenesis) are still unclear. Therefore, we studied the consequences of ear corticosteroid exposure for epileptogenesis, under highly controlled conditions in an animal model. Experimental febrile seizures (eFS) … Show more

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Cited by 17 publications
(18 citation statements)
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“…The findings of the present study regarding peripheral indices of HPA‐axis activity, using very mild variable stress exposure every other day between PND12 and PND24, are largely in line with studies in mice using other ELS paradigms . That is, body weight gain was attenuated, (relative) thymus weight was reduced and (relative) adrenal weight was increased, although only transiently.…”
Section: Discussionsupporting
confidence: 89%
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“…The findings of the present study regarding peripheral indices of HPA‐axis activity, using very mild variable stress exposure every other day between PND12 and PND24, are largely in line with studies in mice using other ELS paradigms . That is, body weight gain was attenuated, (relative) thymus weight was reduced and (relative) adrenal weight was increased, although only transiently.…”
Section: Discussionsupporting
confidence: 89%
“…We selected the model of HT‐induced prolonged seizures, which has the advantage of allowing for (stress) manipulation during the period of epileptogenesis . The first reason to select this model is related to the subtle character of the model, easily allowing the investigation of putative exacerbation caused by subsequent repetitive stressors and avoiding ceiling effects.…”
Section: Discussionmentioning
confidence: 99%
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“…Most literatures talk about anxiety, but a very few intend to define it, because it is a subjective feeling and even the DSM in any version talks about it as a comorbidity of many pathologies, but does not define it as such; the proposal is to promote anxiety as an epileptic entity; its definition as another variety of epilepsy when related to temporal lobe epilepsy or diencephalic alterations belonging to the limbic system [19][20][21][22].…”
Section: Anxiety Disorders -From Childhood To Adulthoodmentioning
confidence: 99%