Stress effects on the regulation of parturition in different domestic animal species

Nagel, Christina; Aurich, Christine; Aurich, Jörg

doi:10.1016/j.anireprosci.2019.04.011

Cited by 56 publications

(46 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results in mice are partially in agreement with those reported in rats; cessation of prenatal maternal stress in rats does not fully restore timing of delivery (26). This discrepancy could be explained by variations in how different species respond to stress (94,95). Yet, our finding in mice holds tangible and immediate public health relevance given the implication that daughters of stressed mothers may be able to manage the impacts of ancestral stress during their pregnancy.…”

Section: Discussionsupporting

confidence: 84%

Prenatal Maternal Stress Causes Preterm Birth and Affects Neonatal Adaptive Immunity in Mice

et al. 2020

View full text Add to dashboard Cite

Maternal stress is a well-established risk factor for preterm birth and has been associated with adverse neonatal outcomes in the first and subsequent generations, including increased susceptibility to disease and lasting immunological changes. However, a causal link between prenatal maternal stress and preterm birth, as well as compromised neonatal immunity, has yet to be established. To fill this gap in knowledge, we used a murine model of prenatal maternal stress across three generations and high-dimensional flow cytometry to evaluate neonatal adaptive immunity. We report that recurrent prenatal maternal stress induced preterm birth in the first and second filial generations and negatively impacted early neonatal growth. Strikingly, prenatal maternal stress induced a systematic reduction in T cells and B cells, the former including regulatory CD4+ T cells as well as IL-4-and IL-17A-producing T cells, in the second generation. Yet, neonatal adaptive immunity gained resilience against prenatal maternal stress by the third generation. We also show that the rate of prenatal maternal stress-induced preterm birth can be reduced upon cessation of stress, though neonatal growth impairments persisted. These findings provide evidence that prenatal maternal stress causes preterm birth and affects neonatal immunity across generations, adverse effects that can be ameliorated upon cessation.

show abstract

Section: Discussionsupporting

confidence: 84%

Prenatal Maternal Stress Causes Preterm Birth and Affects Neonatal Adaptive Immunity in Mice

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Fetal adrenocortical activation [30] but also maternal stress associated with increased cortisol release [31,32] initiate the endocrine cascade that finally leads to foaling. Shetland mares in our study foaled earlier than Warmblood mares A shorter gestation length in ponies compared to large-size horse breeds confirms previous studies [21,33,34] but so far has not been associated with fetomaternal stress.…”

Section: Discussionmentioning

confidence: 99%

Differences in Endocrine and Cardiac Changes in Mares and Her Fetus before, during, and after Parturition in Horses of Different Size

Nagel¹,

Melchert

Aurich

et al. 2020

Animals

Self Cite

View full text Add to dashboard Cite

Equine fetomaternal monitoring is based on endocrine and cardiac parameters which may differ among small, medium-size, and full-size horses. Therefore, Shetland (n = 6), Haflinger (n = 8), and Warmblood pregnancies (n = 9) were studied during late gestation and at foaling. Weight of mares, foals and placenta, plasma progestin and cortisol concentration, heart rate and heart rate variability (HRV) were determined. Foal weight always approximated 10% of mare weight but relative placenta weight was highest in full-size mares (p < 0.05). Progestin (p < 0.001) and cortisol (p < 0.05) concentration was highest in full-size mares. Progestin concentration decreased towards parturition (p < 0.001) while cortisol concentration increased (p < 0.01). Maternal heart rate increased before foaling with the most pronounced increase in small mares (p < 0.001). The HRV increased during foaling and decreased when delivery was completed (p < 0.001). Changes were most pronounced in full-size mares (p < 0.001). Atrio-ventricular blocks regularly occurred in parturient full-size mares but only occasionally in medium-size and small mares (time p < 0.05, time × group p < 0.05). This may reflect breed differences in cardiovascular efficiency. Fetal heart rate decreased towards birth (p < 0.001) with the most pronounced decrease in full-size horses (p < 0.01). Fetal HRV showed no consistent changes before birth but increased when the foal was born (p < 0.001), this increase being most pronounced in full-size foals (p < 0.05). In conclusion, this study demonstrates both similarities and differences in peripartum endocrine and cardiac changes in horses of different size.

show abstract

“…The experiment was carried out on F2 captive-born, wild rabbit genotype resulting in that does were not selected for the captive environment and showed high behavioral variability. As a result that cortisol plays a role in the regulation of parturition in many farm animal species [39], it can be hypothesized that rabbit nest-building behavior is also affected by individual stress sensitivity. Exploring the impact of environmental stress on behavior requires further studies.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Genetic Background of the Differences in Nest-Building Behavior in European Rabbit

Benedek

Altbäcker

Zsolnai³

et al. 2020

Animals

View full text Add to dashboard Cite

Once a day, nursing and absentee mothering make the wild rabbit (Oryctolagus cuniculus) an ideal model animal for measuring differences in maternal behavior. Behavioral events and their hormonal regulation leading to parturition are well documented; however, the genetic background behind individual differences in this complex process is unknown. Decreased progesterone hormone level and the reduction of progesterone receptor activity are crucial to initiating the collection of nest material. The progesterone receptor gene is a likely candidate affecting nest-building behavior. In addition to several known point mutations in the progesterone receptor gene of the European wild rabbit, we have found a new mutation in the promoter region of the gene at 2682 T > C. Although this new single nucleotide polymorphism (SNP) was not involved in the formation of the nest-building behavior, an SNP (2464G > A) already described in the promoter region showed an association with individual differences in the initiation of hay carrying. The distribution of this SNP delivered an opposite result compared to domestic rabbits. Genotype (GG) with high uterine capacity was most frequent; the hereditary value of the trait was h2 = 0.10. Thus, progesterone receptor gene polymorphism may manifest in individual differences affecting breeding success in this species.

show abstract

Stress effects on the regulation of parturition in different domestic animal species

Cited by 56 publications

References 87 publications

Prenatal Maternal Stress Causes Preterm Birth and Affects Neonatal Adaptive Immunity in Mice

Prenatal Maternal Stress Causes Preterm Birth and Affects Neonatal Adaptive Immunity in Mice

Differences in Endocrine and Cardiac Changes in Mares and Her Fetus before, during, and after Parturition in Horses of Different Size

Exploring the Genetic Background of the Differences in Nest-Building Behavior in European Rabbit

Contact Info

Product

Resources

About