Stretchable skin hydrating PVB patches with controlled pores' size and shape for deliberate evening primrose oil spreading, transport and release

Krysiak, Zuzanna J.; Szewczyk, Piotr K.; Berniak, Krzysztof; Sroczyk, Ewa A.; Boratyn, Elżbieta; Stachewicz, Urszula

doi:10.1016/j.bioadv.2022.212786

Cited by 20 publications

(22 citation statements)

References 60 publications

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“…Finally, the cell proliferation was reduced for all the samples on a similar level, as there was only a slight difference in the urea cumulative release between the samples ( Figure 3 A). This phenomenon can be considered as a drawback for tissue engineering; however, the direct biocompatibility of PVB has already been verified with fibroblasts (NIH 3T3) and keratinocytes (HaCaT) [ 7 , 34 ]. Thus, in this study, the decreased cell proliferation is strictly correlated with the urea presence, as the number of keratinocytes started to be reduced, when the urea reached the maximum concentration ( Figure 3 A).…”

Section: Resultsmentioning

confidence: 99%

“…Electrospun fibers were applied as a patch for skin hydration improvement [ 6 ]. They were loaded with evening primrose, borage or blackcurrant seed oil and used as reservoirs, which slowly released the oil and moisturized the skin [ 7 , 8 , 9 ]. Moreover, electrospun fibers are widely used as drug delivery system with controlled release [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…Within this study, we selected poly(vinyl butyral-co-vinyl alcohol-co-vinyl acetate) (PVB) nanofibers, as they showed great skin hydration in vivo, while loaded with the evening primrose oil [ 7 ]. Thus, PVB fibrous membrane can be applied as a multifunctional dressing with additional modification using other skin curing substances.…”

Section: Introductionmentioning

confidence: 99%

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Urea-Based Patches with Controlled Release for Potential Atopic Dermatitis Treatment

Krysiak

Stachewicz

2022

Pharmaceutics

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Skin diseases such as atopic dermatitis (AD) are widespread and affect people all over the world. Current treatments for dry and itchy skin are mostly focused on pharmaceutical solutions, while supportive therapies such as ointments bring immediate relief. Electrospun membranes are commonly used as a drug delivery system, as they have a high surface to volume area, resulting in high loading capacity. Within this study we present the manufacturing strategies of skin patches using polymer membranes with active substances for treating various skin problems. Here, we manufactured the skin patches using electrospun poly(vinyl butyral-co-vinyl alcohol-co-vinyl acetate) (PVB) fibers blended and electrosprayed with urea. The highest cumulative release of urea was obtained from the PVB patches manufactured via blend electrospinning with 5% of the urea incorporated in the fiber. The maximum concentration of released urea was acquired after 30 min, which was followed up by 6 h of constant release level. The simultaneous electrospinning and electrospraying limited the urea deposition and resulted in the lowest urea incorporation followed by the low release level. The urea-based patches, manufactured via blend electrospinning, exhibited a great potential as overnight treatment for various skin problems and their development can bring new trends to the textile-based therapies for AD.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Urea-Based Patches with Controlled Release for Potential Atopic Dermatitis Treatment

Krysiak

Stachewicz

2022

Pharmaceutics

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“…Moreover, PVB patches loaded with evening primrose oil showed a similar behavior. The release of the oil absorbed in the electrospun fibers depends on the fiber diameter (Krysiak et al, 2022).…”

Section: Electrospinningmentioning

confidence: 99%

Electrospun fibers as carriers for topical drug delivery and release in skin bandages and patches for atopic dermatitis treatment

Krysiak

Stachewicz

2022

WIREs Nanomed Nanobiotechnol

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The skin is a complex layer system and the most important barrier between the environment and the organism. In this review, we describe some widespread skin problems, with a focus on eczema, which are affecting more and more people all over the world. Most of treatment methods for atopic dermatitis (AD) are focused on increasing skin moisture and protecting from bacterial infection and external irritation. Topical and transdermal treatments have specific requirements for drug delivery. Breathability, flexibility, good mechanical properties, biocompatibility, and efficacy are important for the patches used for skin. Up to today, electrospun fibers are mostly used for wound dressing.Their properties, however, meet the requirements for skin patches for the treatment of AD. Active agents can be incorporated into fibers by blending, coaxial or side-by-side electrospinning, and also by physical absorption postprocessing. Drug release from the electrospun membranes is affected by drug and polymer properties and the technique used to combine them into the patch. We describe in detail the in vitro release mechanisms, parameters affecting the drug transport, and their kinetics, including theoretical approaches. In addition, we present the current research on skin patch design. This review summarizes the current extensive know-how on electrospun fibers as skin drug delivery systems, while underlining the advantages in their prospective use as patches for atopic dermatitis.

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“…Polyvinyl butyral (PVB) is widely used as photovoltaic encapsulation materials, safety glass interlayers, coatings, and adhesives because of its excellent mechanical strength, high optical transparency, and strong adhesion properties. − In recent years, PVB has been considered as one of the attractive materials for the preparation of polymeric nanocomposites for wastewater treatment due to its flexible molecular chains, low glass-transition temperature ( T g ), good biocompatibility, and hydroxyl hydrophilicity. − The properties of PVB depend largely on its synthesis process, which is mainly the acetal reaction of polyvinyl alcohol (PVA) and butyraldehyde (BA) under acidic conditions . Due to the fast acetal reaction, the product molecules are more difficult to be well dispersed in a short time, which easily leads to product agglomeration and uneven acetalization.…”

Section: Introductionmentioning

confidence: 99%

Adsorption of Sodium Dodecyl Sulfonate from Aqueous Solution by Polyvinyl Butyral: Kinetics and Thermodynamics

Sun

Zeng

2023

Ind. Eng. Chem. Res.

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During the synthesis of polyvinyl butyral (PVB), sodium dodecyl sulfonate (SDS) is generally added in appropriate amounts, which prevents PVB from agglomeration but also causes PVB to turn yellow. The removal of SDS and its final residue in PVB are closely related to the adsorption performance of SDS on PVB. In this study, PVB with a high acetal degree (81.96 mol %) was synthesized by polyvinyl alcohol and butyraldehyde and was characterized by 1H NMR, Fourier transform infrared spectroscopy, scanning electron microscopyenergy-dispersive X-ray spectroscopy, and other methods. The adsorption properties of SDS on PVB were investigated under different initial pHs, PVB doses, PVB particle sizes, contact times, initial SDS concentrations, and temperatures. The adsorption kinetic data were analyzed using pseudo-first-order, pseudo-second-order, Elovich, and intraparticle diffusion models. The results showed that the pseudo-second-order model fitted the adsorption data well, and the intraparticle diffusion was not the only control mechanism for PVB adsorption. The equilibrium data were analyzed with Langmuir, Freundlich, Temkin, and Dubinin–Radushkevich models. The results showed that the adsorption data conformed to the Langmuir model, and the maximum adsorption capacity of PVB for SDS was 40.5168 mg/g at 290.15 K. Moreover, the Dubinin–Radushkevich model illustrated that the adsorption process was chemisorption at low SDS concentrations and physical adsorption otherwise. The thermodynamic parameters showed that the adsorption of SDS on PVB was spontaneous and exothermic. In conclusion, the research results provide some basis for the PVB purification plant equipment.

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Stretchable skin hydrating PVB patches with controlled pores' size and shape for deliberate evening primrose oil spreading, transport and release

Cited by 20 publications

References 60 publications

Urea-Based Patches with Controlled Release for Potential Atopic Dermatitis Treatment

Urea-Based Patches with Controlled Release for Potential Atopic Dermatitis Treatment

Electrospun fibers as carriers for topical drug delivery and release in skin bandages and patches for atopic dermatitis treatment

Adsorption of Sodium Dodecyl Sulfonate from Aqueous Solution by Polyvinyl Butyral: Kinetics and Thermodynamics

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