Stretching and Heating Single DNA Molecules with Optically Trapped Gold–Silica Janus Particles

Simoncelli, Sabrina; Johnson, Samuel C.; Kriegel, Franziska; Lipfert, Jan; Feldmann, Jochen

doi:10.1021/acsphotonics.7b00839

Cited by 21 publications

(23 citation statements)

References 66 publications

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“…For example, the Janus mesoporous silica nanoparticles (Figure e−h) can serve as efficient carriers for drug delivery with high loading capacity . The Janus nanomotors can be integrated with a variety of biomolecules including DNA, protein, and antibody molecules, showing excellent application prospects in pharmaceuticals . As a substitute for organic tissues, polymers have been widely applied in clinical medicine.…”

Section: Discussionmentioning

confidence: 99%

“…[45] The Janus nanomotors can be integrated with a variety of biomolecules including DNA, protein, and antibody molecules, showing excellent application prospects in pharmaceuticals. [93] As a substitute for organic tissues, polymers have been widely applied in clinical medicine. The diversity of polymers makes it possible to prepare nanomotors with better biocompatibility.…”

Section: Discussionmentioning

confidence: 99%

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Recent Progress in Optical‐Resonance‐Assisted Movement Control of Nanomotors

Zheng

Lam

Huang

et al. 2020

Advanced Intelligent Systems

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Light exerts force or torque on objects through the momentum or angular momentum exchange between photons and the objects. For absorbing structures, light also induces a thermal gradient that can be used to power the object movement. The light‐driven mechanism, with the advantages of wireless, versatile modulation, and excellent spatial and temporal resolution, is very attractive and triggers various studies on micro‐ and nanomotors controlled by light. However, when the size of the motor becomes smaller and reaches the nanoscale, their interaction with light decreases and therefore it is very challenging to overcome the random Brownian motions. Optically resonant nanomotors can break such limitations. Alternatively, one can use optically resonant structures that significantly confine the light energy to control the movements of nanoobjects. Herein, the recent research on state‐of‐the‐art light resonant nanomotors, which includes both optically resonant nanomotors and nanomotors controlled by optically resonant nanostructures, is discussed. Their driving mechanisms, movement control, limitations, and possible improvements are introduced in detail. The exploration of the light resonant nanomotors in various applications is also introduced. Finally, an outlook on the future development of light resonant nanomotors is provided.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Recent Progress in Optical‐Resonance‐Assisted Movement Control of Nanomotors

Zheng

Lam

Huang

et al. 2020

Advanced Intelligent Systems

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“…Achim Löf et al present multiplexed protein force spectroscopy reveals equilibrium protein folding dynamics and the low-force response of von Willebrand factor [86]. (Reprinted with permission from [61]. Copyright (2017) American Chemical Society.)…”

Section: Foldingmentioning

confidence: 99%

Nanomanipulation in Biomedical Applications

2021

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Purpose of Review Progress in nanorobotics over the past decades has dramatically extended our ability to explore the world down to individual molecules/atoms. As an enabling technology, nanorobotic manipulation provides the capability to the control of position and orientation of an object. This paper overviews the state-of-the-art of the advancements of nanomanipulation and focuses on its application in biomedicine. Recent Findings As the literature is showing, recent progresses on nanomanipulation have mainly been enabled by such supporting techniques as super-resolution imaging and local magnetic/plasmonic actuation, and focused on the exploration of molecular properties on an individual non-statistical basis, which includes the characterization of mechanical properties, conformational transitions, position/posture adjustment, intra-/intermolecular interactions of bio-objects, and so on. Summary Following a review focusing on recent advances in applications of nanomanipulation based on various platforms and processes (including both probe and field-based approaches) into biomedicine, future perspectives and potential trends are discussed.

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“…The Au layer was half‐coated through conventional PVD, followed by ultrasonic treatment and centrifugation. The force generated by self‐thermophoretically driven Au−SiO 2 Janus particles could stretch individual double‐stranded DNA molecules . Furthermore, the synergistic effect of self‐thermophoresis and active targeting of cancer cells by coating the macrophage cell membrane (MPCM) on the Au−SiO 2 Janus nanomotors was reported (Figure A) .…”

Section: Fabricationmentioning

confidence: 99%

Fabrication of Self‐Propelled Micro‐ and Nanomotors Based on Janus Structures

Luan

Wang

et al. 2019

Chemistry A European J

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Delicate molecular and biological motors are tiny machines capable of achieving numerous vital tasks in biological processes. To gain ad eeper understanding of their mechanism of motion, researchers from multiple backgrounds have designed andf abricated artificial micro-and nanomotors. These nano-/microscale motors can self-propel in solution by exploiting different sources of energy;t hus showing tremendous potentiali nw idespread applications. As one of the most common motor systems, Janus motors possessunique asymmetric structures and integrate different functional materials onto two sides. This review mainly focuses on the fabrication of different types of micro-and nanomotors based on Janus structures. Furthermore, some challenges still exist in the implementation of Janus motors in the biomedical field. With such common goals in mind, it is expected that the elaborate and multifunctional design of Janus motors will overcome their challenges in the near future.

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Stretching and Heating Single DNA Molecules with Optically Trapped Gold–Silica Janus Particles

Cited by 21 publications

References 66 publications

Recent Progress in Optical‐Resonance‐Assisted Movement Control of Nanomotors

Recent Progress in Optical‐Resonance‐Assisted Movement Control of Nanomotors

Nanomanipulation in Biomedical Applications

Fabrication of Self‐Propelled Micro‐ and Nanomotors Based on Janus Structures

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