Abstract:A
BSTRACT
Introduction:
κ-opioid receptor (KOPr) system has been linked to relapse to many substances, especially opioids. Positive responses were recently reported in morphine and methamphetamine (polydrug)-dependent mice treated with buprenorphine and naltrexone, a functional κ antagonist.
Objectives:
This study aimed to determine the specific brain region that is responsive to KOPr treatment following polydrug dependence.
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