2020
DOI: 10.4103/jpbs.jpbs_379_19
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Striatum hyperactivity triggers relapse to morphine and methamphetamine (polydrug) dependence in mice

Abstract: A BSTRACT Introduction: κ-opioid receptor (KOPr) system has been linked to relapse to many substances, especially opioids. Positive responses were recently reported in morphine and methamphetamine (polydrug)-dependent mice treated with buprenorphine and naltrexone, a functional κ antagonist. Objectives: This study aimed to determine the specific brain region that is responsive to KOPr treatment following polydrug dependence. Mat… Show more

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