Stroke and Atrial Fibrillation

Extramiana, Fabrice; Maison‐Blanche, Pierre

doi:10.1161/strokeaha.114.007809

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…Following stroke, the affected area of the brain cannot function normally, which may result in disability and even death. 21 Substantial efforts are still being devoted to deciphering the complex mechanisms of stroke. Interestingly, accumulated studies have shown that angiogenesis is activated after stroke and that higher neovascular density is associated with less morbidity, disability and mortality.…”

Section: Discussionmentioning

confidence: 99%

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Long non‐coding RNA MALAT1 regulates angiogenesis following oxygen‐glucose deprivation/reoxygenation

Wang

Suo

et al. 2019

J Cellular Molecular Medi

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Long non‐coding RNAs (lncRNAs) have been identified as playing critical roles in multiple diseases. However, little is known regarding their roles and mechanisms in post‐stroke angiogenesis. Our studies focused on deciphering the functional roles and the underlying mechanisms of the lncRNA metastasis‐associated lung adenocarcinoma transcript 1 (MALAT1) in the process of angiogenesis following oxygen‐glucose deprivation/reoxygenation (OGD/R). We characterized the up‐regulation of MALAT1 expression in the process of angiogenesis after hypoxic injury in vivo and in vitro. We further showed that compared with the empty vector, MALAT1 knockdown had significantly reduced the capacity for angiogenesis, which was measured by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium (MTT), scratching, cell cycle and immunofluorescent staining. Thus, our findings suggest that MALAT1 may mediate proangiogenic function in OGD/R. To further explore the potential mechanisms, we used lentiviruses expressing shMALAT1 and empty vector; the results revealed that shMALAT1 reduced the expression of 15‐lipoxygenase 1 (15‐LOX1), vascular endothelial growth factor (VEGF) and the phosphorylation of signal transducers and activators of transcription 3 (pSTAT3). Taken together, our results are the first to propose that MALAT1 may regulate angiogenesis through the 15‐LOX1/STAT3 signalling pathway, and they may provide a critical target for the treatment of hypoxic injury and an avenue for therapeutic angiogenesis.

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Section: Discussionmentioning

confidence: 99%

“…Stroke, as a cerebrovascular accident, causes a loss of brain function due to a disturbance in the blood supply to the brain. Following stroke, the affected area of the brain cannot function normally, which may result in disability and even death . Substantial efforts are still being devoted to deciphering the complex mechanisms of stroke.…”

Section: Discussionmentioning

confidence: 99%

Long non‐coding RNA MALAT1 regulates angiogenesis following oxygen‐glucose deprivation/reoxygenation

Wang

Suo

et al. 2019

J Cellular Molecular Medi

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“…Therefore efforts to standardize such research, establish validated algorithms of investigation in these diverse populations, and assess standardized arrhythmic markers for their prognostic outcomes is badly needed. [12][13][14][15][16] A noncomplete review of arrhythmic markers appearing in the recent medical literature from diverse detection methods on a variety of medical instruments in multiple populations, illustrates and highlights the current existing chaos (Table 1). [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] Moreover, there is an appreciation that current clinical trials in progress predominantly employ relatively expensive invasive devices that advance our understanding without recognition of perhaps less costly noninvasive methodologies that could be employed if an investigative guideline algorithm existed.…”

Section: Arrhythmia Detectionmentioning

confidence: 99%

“…This presentation seeks to examine this quandary, provide some definitions, and present unanswered issues that need to be addressed by the scientific community at large. The need for such a focus and clarification has been appreciated by many authors recently, [12][13][14][15][16] and should prove valuable for future research of atrial fibrillation.…”

Section: Introductionmentioning

confidence: 99%

Silent Atrial Fibrillation: Definition, Clarification, and Unanswered Issues

Kennedy

2015

Ann Noninvasive Electrocardiol

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Silent or subclinical asymptomatic atrial fibrillation has currently gained wide interest in the epidemiologic, neurologic and cardiovascular communities. The association of brief episodes of paroxysmal atrial fibrillation or surrogate atrial arrhythmias which predict future clinical adverse events have been established. Nevertheless there exists a confounding array of definitions to indicate its presence without discrete indication of which populations should be examined. Moreover the term "atrial fibrillation burden" (AFB) has emerged from such studies with a plethora of descriptions to prognosticate both arrhythmic and clinical adverse events. This presentation suggests clarification of diagnostic definitions associated with silent atrial fibrillation, and a more precise description of AFB. It examines the populations across the current disease and cardiovascular invasive therapeutic spectrum that lead to both silent atrial fibrillation and AFB. It describes the diagnostic methods of arrhythmia detection utilizing the surface ECG, subcutaneous ECG or intra-cardiac devices and their relationship in seeking meaningful arrhythmic markers of silent atrial fibrillation. Whereas a wide range of clinical risk factors of silent atrial fibrillation have been validated in the literature, there is an ongoing search for those arrhythmic risk factors that precisely identify and prognosticate outcome events in diverse populations at risk of atrial fibrillation and its complications. This presentation identifies this chaos, and focuses attention on the issues to be addressed to facilitate descriptive and comparative scientific studies in the future. It is a call to action specifically to the medical arrhythmic community and its specialty societies (i.e., ISHNE, HRS, EHRA) to begin a quest to unravel the arrhythmic quagmire associated with "silent atrial fibrillation."Ann Noninvasive Electrocardiol 2015;20(6):518-525

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The emerging role of signal transducer and activator of transcription 3 in cerebral ischemic and hemorrhagic stroke

Liang

Fan

et al. 2016

Progress in Neurobiology

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Stroke and Atrial Fibrillation

Cited by 4 publications

References 18 publications

Long non‐coding RNA MALAT1 regulates angiogenesis following oxygen‐glucose deprivation/reoxygenation

Long non‐coding RNA MALAT1 regulates angiogenesis following oxygen‐glucose deprivation/reoxygenation

Silent Atrial Fibrillation: Definition, Clarification, and Unanswered Issues

The emerging role of signal transducer and activator of transcription 3 in cerebral ischemic and hemorrhagic stroke

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