Stroke Incidence and Mortality Trends in US Communities, 1987 to 2011

Koton, Silvia; Schneider, A; Rosamond, Wayne D.

doi:10.1016/j.jvs.2014.08.084

Cited by 98 publications

(136 citation statements)

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“…Two years ago stroke slipped from the third leading cause of death to the fourth [1], and in 2015 it fell to the fifth leading cause of death [2]. Even with improving treatments for stroke risk factors, and a possible decline in stroke incidence from risk factor control, mortality from stroke will decline faster than the incidence [3]. This fact means that stroke is morphing into a chronically disabling disease.…”

Section: Introductionmentioning

confidence: 99%

The 3 Rs of Stroke Biology: Radial, Relayed, and Regenerative

Carmichael

2016

Neurotherapeutics

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Stroke not only causes initial cell death, but also a limited process of repair and recovery. As an overall biological process, stroke has been most often considered from the perspective of early phases of ischemia, how these inter-relate and lead to expansion of the infarct. However, just as the biology of later stages of stroke becomes better understood, the clinical realities of stroke indicate that it is now more a chronic disease than an acute killer. As an overall biological process, it is now more important to understand how early cell death leads to the later, limited recovery so as develop an integrative view of acute to chronic stroke. This progression from death to repair involves sequential stages of primary cell death, secondary injury events, reactive tissue progenitor responses, and formation of new neuronal circuits. This progression is radial: from the tissue that suffers the infarct secondary injury signals, including free radicals and inflammatory cytokines, radiate out from the stroke core to trigger later regenerative events. Injury and repair processes occur not just in the local stroke site, but are also triggered in the connected networks of neurons that had existed in the stroke center: damage signals are relayed throughout a brain network. From these relayed, distributed damage signals, reactive astrocytosis, inflammatory processes, and the formation of new connections occur in distant brain areas. In short, emerging data in stroke cell death studies and the development of the field of stroke neural repair now indicate a continuum in time and in space of progressive events that can be considered as the 3 Rs of stroke biology: radial, relayed, and regenerative.

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Section: Introductionmentioning

confidence: 99%

The 3 Rs of Stroke Biology: Radial, Relayed, and Regenerative

Carmichael

2016

Neurotherapeutics

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“…Keadaan ini sesuai dengan data di Indonesia bahwa pada umumnya strok mengenai usia di atas 40 tahun dan hasil penelitian oleh Koton dkk. 16 bahwa usia ratarata pasien strok di Amerika adalah 54,1 tahun. Menurut penelitian oleh Siddique dkk.…”

Section: Pembahasanunclassified

Efektivitas Latihan Penguatan terhadap Kemampuan Fungsional Anggota Gerak Atas pada Pasien Strok Iskemi Fase Subakut

Tresnasari

Basuki

Defi

2017

GMHC

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AbstrakStrok merupakan penyakit dengan gejala utama kelemahan satu sisi tubuh. Kelemahan anggota gerak atas (AGA) menyebabkan penurunan kemampuan fungsionalnya. Kekuatan adalah salah satu indikator performa fungsional anggota gerak atas. Tujuan penelitian ini mengetahui efektivitas latihan penguatan anggota gerak atas terhadap peningkatan kekuatan dan kemampuan fungsional anggota gerak atas pada pasien strok iskemi fase subakut dengan menggunakan bola dan pita elastik. Rancangan penelitian adalah eksperimental dan dilaksanakan di Departemen Ilmu Kedokteran Fisik dan Rehabilitasi, RSUP Dr. Hasan Sadikin Bandung periode Desember 2013-Juli 2014. Subjek terdiri atas 21 pasien strok iskemi fase subakut berusia 40-59 tahun. Latihan penguatan dengan pita dan bola elastik dilakukan oleh semua subjek, 3 kali seminggu selama 6 minggu, 2 set setiap latihan, dan 8 repetisi setiap set. Sebelum, setelah 2 minggu, 4 minggu, dan 6 minggu latihan dinilai kekuatan dan fungsi anggota gerak atas. Hasil menunjukkan bahwa latihan penguatan meningkatkan kekuatan anggota gerak atas (p<0,001) dan meningkatkan fungsi anggota gerak atas (p<0,001). Simpulan, latihan penguatan anggota gerak atas dengan pita dan bola elastik efektif meningkatkan kekuatan dan fungsi anggota gerak atas pada pasien strok iskemi fase subakut.Kata kunci: Kekuatan anggota gerak atas, kemampuan fungsional, latihan penguatan, strok iskemi subakut The Effectiveness of Strengthening Exercises on Upper Limbs Functional Ability of Subacute Phase Ischemic Stroke Patients AbstractStroke is a disease with the primary symptoms of weakness. The weakness of the upper limbs caused a decrease in functional ability. Strength is one indicator of upper limb functional performance. The purpose of this study was to determine the effectiveness of upper limb strengthening exercises to increase strength and functional ability of upper limbs in patients with subacute phase ischemic stroke using elastic band and balls. The study was conducted using experimental method, performed at the Medical Rehabilitation Division, Dr. Hasan Sadikin General Hospital Bandung from December 2013 to July 2014. Subjects consisted of 21 patients with ischemic stroke subacute phase aged 40-59 years. The strengthening exercises with elastic band and elastic ball were done by all subjects, 3 times a week, for 6 weeks. Each exercise consisted of 2 sets with 8 repetition of each set. Assessment of the strength and upper limbs function done before, after 2 weeks, 4 weeks and 6 weeks of strengthening exercises. Results showed that strengthening exercises increases the strength of the upper limbs (p<0.001) and increases the upper limbs function (p<0.001). Conclusions, upper limbs exercise strengthening with elastic band and elastic ball effectively increased the strength and upper limb function in ischemic stroke subacute phase patients.

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“…Ischemic stroke is a major cause of death and disability in the aged population [34]. During cerebral infarction, transplanted MSCs migrate to areas of damage and mediate tissue healing [35].…”

Section: Mscs In the Treatment Of Ischemic Strokementioning

confidence: 99%

Mesenchymal stem cell-based therapy for ischemic stroke

et al. 2016

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Ischemic stroke represents a major, worldwide health burden with increasing incidence. Patients affected by ischemic strokes currently have few clinically approved treatment options available. Most currently approved treatments for ischemic stroke have narrow therapeutic windows, severely limiting the number of patients able to be treated. Mesenchymal stem cells represent a promising novel treatment for ischemic stroke. Numerous studies have demonstrated that mesenchymal stem cells functionally improve outcomes in rodent models of ischemic stroke. Recent studies have also shown that exosomes secreted by mesenchymal stem cells mediate much of this effect. In the present review, we summarize the current literature on the use of mesenchymal stem cells to treat ischemic stroke. Further studies investigating the mechanisms underlying mesenchymal stem cells tissue healing effects are warranted and would be of benefit to the field.

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Stroke Incidence and Mortality Trends in US Communities, 1987 to 2011

Cited by 98 publications

References 0 publications

The 3 Rs of Stroke Biology: Radial, Relayed, and Regenerative

The 3 Rs of Stroke Biology: Radial, Relayed, and Regenerative

Efektivitas Latihan Penguatan terhadap Kemampuan Fungsional Anggota Gerak Atas pada Pasien Strok Iskemi Fase Subakut

Mesenchymal stem cell-based therapy for ischemic stroke

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