Stroke Prevention in Atrial Fibrillation

Mtwesi, Viwe; Amit, Guy

doi:10.1016/j.mcna.2019.05.006

Cited by 17 publications

(14 citation statements)

References 78 publications

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“…AF independently increases risk of stroke by 4-5-fold (Zhang et al, 2019). Oral anticoagulants reduce risk of stroke by about twothirds in AF patients (Mtwesi and Amit, 2019). Warfarin is still the first-choice drug for the prevention of stroke in many types of AF (January et al, 2019).…”

Section: Efficacy and Safety During Follow-upmentioning

confidence: 99%

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Efficacy and safety of left atrial appendage occlusion in atrial fibrillation patients with chronic kidney disease: a systematic review and meta-analysis

Haifu

Zhang

et al. 2020

Rev. Cardiovasc. Med.

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Atrial fibrillation (AF) is the most common arrhythmia among the elderly, and more frequently occur in those with chronic kidney disease (CKD). Left atrial appendage occlusion (LAAO) is used as a mechanical alternative approach for prevention of AF-related thromboembolisms. This meta-analysis was conducted to provide suggestions for the clinical application of LAAO in AF patients with CKD. The incidence of perioperative adverse events and other clinical effects after operation was by a single rate meta-analysis. Results showed that incidence of adverse events in the perioperative period after LAAO was generally low, with only pericardial effusion / tamponade (1.90%) and mortality rate (1.10%). During the follow-up period, the incidence of stroke/transient ischemic attack (TIA) and bleeding were 2.17% and 4.53%, respectively. A low incidence rate of adverse events was found in the perioperative period following LAAO. These results indicate that LAAO more effectively prevents the occurrence of stroke/TIA and minimizes bleeding events than oral anticoagulants.

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Section: Efficacy and Safety During Follow-upmentioning

confidence: 99%

“…Oral anticoagulants reduce the risk of stroke by two-thirds in AF patients (Mtwesi and Amit, 2019). However, oral anticoagulants undergo varying degrees of kidney clearance, and are associated with a higher risk of bleeding in CKD patients (Shin et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of left atrial appendage occlusion in atrial fibrillation patients with chronic kidney disease: a systematic review and meta-analysis

Haifu

Zhang

et al. 2020

Rev. Cardiovasc. Med.

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“…Management of vascular risk factors (hypertension, hyperlipidemia, diabetes, smoking, new atrial fibrillation and other arrhythmias) is critical, and the use of antiplatelet drugs (aspirin, clopidogrel, etc.) and anticoagulants is recommended according to the stroke prevention guidelines [8,9]. In addition, the use of angiotensin-converting enzyme inhibitors and diuretics can delay the progression of white matter changes in patients with stroke [10].…”

Section: Introductionmentioning

confidence: 99%

Effects of different acupuncture treatment methods on post-stroke cognitive impairment: study protocol for a multicenter randomized controlled trial

Liu

et al. 2021

Trials

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Background Cognitive impairment is a common dysfunction after stroke that seriously affects the overall recovery of patients. Cognitive rehabilitation training is currently the main treatment to improve cognitive function, but its curative effect is limited. Acupuncture is a core component of traditional Chinese medicine (TCM), and some previous clinical studies have shown that it might be effective in treating post-stroke cognitive impairment (PSCI), but further evidence from large-sample studies is needed. The overall objective of this trial is to obtain further data to develop an optimized acupuncture treatment for PSCI by comparing the effects of different acupuncture treatment methods on cognitive function in PSCI patients. Methods/design In this multicenter, prospective, randomized controlled trial, 206 eligible stroke inpatients who meet the trial criteria will be randomly assigned to 2 groups: an electroacupuncture (EA) plus needle retention (NR) group and an EA group. Both groups of patients will undergo the same routine cognitive rehabilitation treatments. All treatments will be given 5 times per week for 8 weeks. The primary outcomes will be assessed using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment scale (MOCA). The secondary outcome will be measured by the Barthel Index (BI). All outcomes will be evaluated at baseline, week 4, week 8, and the third and sixth month after the end of treatment. Discussion Our aim is to evaluate the effects of two different acupuncture treatment methods for treating PSCI patients. This study is expected to provide data to be used in developing an optimized acupuncture treatment method for PSCI treatment. Trial registration Chinese Clinical Trial Registry ChiCTR1900027849. Registered on 30 November 2019, http://www.chictr.org.cn/showproj.aspx?proj=46316

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“…Management of vascular risk factors (hypertension, hyperlipidemia, diabetes, smoking, new atrial brillation and other arrhythmias) is critical, the use of antiplatelet drugs (aspirin, clopidogrel, etc.) and anticoagulants is selected according to the stroke prevention guidelines [8,9]. In addition, the use of angiotensin-converting enzyme inhibitors and diuretics can delay the progress of white matter changes in patients with stroke [10].…”

Section: Introductionmentioning

confidence: 99%

Effects of different acupuncture treatment methods on post-stroke cognitive impairment: study protocol for a multicenter randomized controlled trial

Liu

et al. 2020

Preprint

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Background: Cognitive impairment is one of common dysfunctions after stroke, which seriously affects the overall recovery of patients. Cognitive rehabilitation training is currently the main treatment to improve cognitive function, but its curative effect is limited. Acupuncture is a core component of traditional Chinese medicine (TCM) and some previous clinical studies have shown that it might be effective in treating post-stroke cognitive impairment (PSCI), but further evidence from large-sample studies is needed. The overall objective of this trial is to obtain further data for forming an optimized acupuncture treatment for PSCI by comparing the effects of different acupuncture treatment methods on cognitive function in PSCI patients.Methods/Design: In this multicenter, prospective, randomized controlled trial, 206 eligible stroke inpatients who meet the trial criteria will be randomly assigned to 2 groups: Electroacupuncture (EA) plus needle retaining (NR) group and EA group, both groups of patients undergo the same routine cognitive rehabilitation treatments. All treatments will be given 6 times per week for 8 weeks. The primary outcomes will be assessed using the Mini Mental State Scale (MMSE) and the Montreal Cognition Assessment Scale (MOCA). The secondary outcome will be measured by the Bathel Index (BI). All outcomes will be evaluated at baseline, week 4, week 8, and the third and sixth month after the end of treatments.Discussion: Our aim is to evaluate the effects of two different acupuncture treatment methods for treating PSCI patients. This study is expected to provide data to be used in developing an optimized acupuncture treatment method for PSCI treatment.Trial registration: Chinese Clinical Trial Registry, ChiCTR1900027849. Registered on 30 November 2019, http://www.chictr.org.cn/showproj.aspx?proj=46316

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Stroke Prevention in Atrial Fibrillation

Cited by 17 publications

References 78 publications

Efficacy and safety of left atrial appendage occlusion in atrial fibrillation patients with chronic kidney disease: a systematic review and meta-analysis

Efficacy and safety of left atrial appendage occlusion in atrial fibrillation patients with chronic kidney disease: a systematic review and meta-analysis

Effects of different acupuncture treatment methods on post-stroke cognitive impairment: study protocol for a multicenter randomized controlled trial

Effects of different acupuncture treatment methods on post-stroke cognitive impairment: study protocol for a multicenter randomized controlled trial

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