Stromal cell derived factor-1: its influence on invasiveness and migration of breast cancer cells in vitro, and its association with prognosis and survival in human breast cancer

Abstract

Introduction Stromal cell-derived factor (SDF)-1 (CXC chemokine ligand-12) is a member of the CXC subfamily of chemokines, which, through its cognate receptor (CXC chemokine receptor [CXCR]4), plays an important role in chemotaxis of cancer cells and in tumour metastasis. We conducted the present study to evaluate the effect of SDF-1 on the invasiveness and migration of breast cancer cells, and we analyzed the expression of SDF-1 and its relation to clinicopathological features and clinical outcomes in human breast cancer.

Silencing of epithelial CXCL12 expression by DNA hypermethylation promotes colonic carcinoma metastasis

“…Given recent evidence demonstrating the pro-metastatic roles of CXCR4-CXCL12 signaling in carcinoma cells, one may have expected over-expression of CXCL12 in carcinoma cells to result in increased metastasis (Muller et al, 2001;Kang et al, 2005). The inherent differences between exogenous CXCL12 stimulation and endogenous expression of the protein are undoubtedly responsible for our results compared to previous reports examining the role for CXCR4 in colonic tumorigenesis.…”

A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells

“…Examples are the three strongly ERa upregulated genes, which are all breast cancer related: pS2, BCL2 and GREB1 (Real et al, 2002;Kang et al, 2005;Rae et al, 2005). The strong ERb negative influence on the ERa upregulation of these genes would most likely help in the reduction of tumor proliferation.…”

Omega-3 Polyunsaturated Fatty Acids Down-Modulate CXCR4 Expression and Function in MDA-MB-231 Breast Cancer Cells

“…CXCR4 is the most prominent chemokine receptor expressed on breast cancer cells and is not expressed on normal breast cells (1). CXCR4 is a major factor in breast cancer metastasis due to migration of the cancerous cells through CXCL12 signaling to surrounding tissues (9)(10)(11)(12)(13)(14). This is achieved largely because CXCL12 is present in almost all major tissues.…”