Stromal cell-derived factor-1 (SDF-1) alleles and susceptibility to breast carcinoma

Razmkhah, Mahboobeh; Talei, Abdolrasoul; Doroudchi, Mehrnoosh; Khalili-Azad, Tahereh; Ghaderi, Abbas

doi:10.1016/j.canlet.2004.10.039

Cited by 70 publications

(55 citation statements)

References 26 publications

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“…The mutation was found significantly more often in the patient group as compared to controls (28,29). These data suggest that CXCL12 polymorphism might contribute to tumor development in breast cancer patients.…”

Section: Discussionmentioning

confidence: 56%

SNP rs1801157 significantly correlates with distant metastasis in CXCL12 expressing esophagogastric cancer

Schimanski

Jordan²,

Schlaegel³

et al. 2011

Int J Oncol

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Abstract. We performed this study in order to evaluate the impact of the chemokine CXCL12 and its single-nucleotide polymorphism (SNP) rs1801157 on clinicopathological parameters and survival in patients undergoing surgery for esophagogastric cancer. The expression pattern of CXCL12 and its polymorphisms were analyzed by RT-PCR and PCR-RFLP in 69 consecutive fresh-frozen samples of human esophagogastric junction and gastric adenocarcinomas and statistically analyzed. Expression of the CXCL12 (SNP rs1801157) polymorphisms GA/AA significantly correlated with distant metastasis (P=0.026), but not with prognosis. However, CXCL12 expression was not significantly associated with the tumor infiltration depth, lymphatic metastasis and grading. As CXCL12 polymorphisms mediate tumor cell dissemination in esophagogastric cancer, they could represent a marker indicating advanced disease. Antagonists targeting the CXCL12/ CXCR4 axis may be a novel therapeutic option in this entity.

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Section: Discussionmentioning

confidence: 56%

SNP rs1801157 significantly correlates with distant metastasis in CXCL12 expressing esophagogastric cancer

Schimanski

Jordan²,

Schlaegel³

et al. 2011

Int J Oncol

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“…The most compelling evidence for the role of the SdF-1 G→a polymorphism in malignancy is provided by previous genotype and allele-frequency studies showing that this specific polymorphism is associated with a susceptibility to breast, lung and prostate cancer (36,38,(40)(41)(42). in the current study, we attempted to determine whether an association exists between this SdF-1 gene variant and pancreatic cancer.…”

Section: Discussionmentioning

confidence: 91%

“…on the other hand, current studies on colorectal cancer have failed to suggest a serious impact of the SdF-1 polymorphism on the risk of colorectal cancer development (43,44). Hypothetically, different mechanisms involved in the pathogenesis of colorectal carcinogenesis, along with a host of modifying molecular events, may account for this lack of association, in contrast to the documented role of the SdF-1 polymorphism in breast, lung, prostate and pancreatic cancer (36,38,(40)(41)(42). in other words, based on tissue origin, the influence of the sDF-1 gene polymorphism may contribute differentially between malignancies in mediating tumor progression, angiogenesis, metastasis and leukocyte migration.…”

Section: Discussionmentioning

confidence: 99%

“…This single nucleotide polymorphism of the SdF-1 gene has been investigated in type 1 diabetes and HiV-1 infection, and has been reported to be associated with an increased risk of non-Hodgkin's lymphoma in HiV-1 infected individuals (30,34,35). The SdF-1 G→a polymorphism has been investigated in various cancers, but no information is currently available regarding its role in pancreatic cancer (36)(37)(38)(39)(40)(41)(42)(43)(44).…”

Section: Introductionmentioning

confidence: 99%

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Analysis of the stromal cell-derived factor 1-3'A gene polymorphism in pancreatic cancer

Theodoropoulos

Panoussopoulos²,

Michalopoulos³

et al. 2010

Mol Med Rep

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Abstract.Stromal cell derived factor-1 (SdF-1), a cXc chemokine that plays an important role in the tumor growth, angiogenesis and metastasis of tumor cells, has a polymorphism at position 801 of its 3'-untranslated region, known as SdF1-3' a. The SdF1-3' a polymorphism has been investigated in various types of cancer, but no information is currently available on its role in pancreatic cancer. in this study, 80 pancreatic cancer patients and 160 normal healthy control subjects were investigated for the genotype and allelic frequencies of the SdF-1 gene using Pcr-rFlP. The genotype frequencies for GG, Ga and aa were 21.25, 77.5 and 1.25% in patients, and 42.5, 55 and 2.5% in healthy subjects, respectively. The a carrier group (Ga+aa genotype) and the a allele were overrepresented among the patients with pancreatic cancer (p=0.015 and p=0.031, respectively). The Ga+aa genotype was statistically correlated with an advanced T stage and the presence of lymph node metastasis, and displayed a clear trend towards significance in relation to the presence of distant metastatic disease (p=0.061). Only T stage was significantly related to a allele frequency (p=0.004). SdF1-3' a allele carriers were more prevalent among cancer patients than among normal subjects. SdF1-3' a allele carrier status may imply a higher risk of pancreatic cancer, while the presence of the a allele in pancreatic cancer patients may be related to aggressive features of this malignancy.

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“…Myofibroblasts associated with breast cancer, but not those in normal breast tissue, produce CXCL12 and enhance growth of tumours through mechanisms that include proliferation and survival of malignant cells and angiogenesis (Allinen et al, 2004;Orimo et al, 2005). Specific alleles of CXCL12 are associated with an increased risk of breast cancer (Razmkhah et al, 2005), and CXCL12 has been shown to transactivate ErbB-2 (Cabioglu et al, 2005). CXCR4 expression was also identified as a predictive factor of worse outcome in some metastatic tumours and in malignant gliomas (Scala et al, 2005;Ottaiano et al, 2006;Bian et al, 2007).…”

Section: Chemokines and Chemokine Receptorsmentioning

confidence: 99%

Brain Metastases Progression of Breast Cancer

Moustafa¹,

Yasmeen²,

Ghabreau³

et al. 2011

Breast Cancer - Carcinogenesis, Cell Growth and Signalling Pathways

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Stromal cell-derived factor-1 (SDF-1) alleles and susceptibility to breast carcinoma

Cited by 70 publications

References 26 publications

SNP rs1801157 significantly correlates with distant metastasis in CXCL12 expressing esophagogastric cancer

SNP rs1801157 significantly correlates with distant metastasis in CXCL12 expressing esophagogastric cancer

Analysis of the stromal cell-derived factor 1-3'A gene polymorphism in pancreatic cancer

Brain Metastases Progression of Breast Cancer

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