2006
DOI: 10.1136/gut.2005.081117
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Strong BCL10 nuclear expression identifies gastric MALT lymphomas that do not respond to H pylori eradication

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Cited by 63 publications
(39 citation statements)
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“…48 Most of the t(1;14) positive cases are diagnosed at advanced stages. 63 Our recent study indicates that gastric MALT lymphoma with t(1;14)/strong BCL10 nuclear expression is most unlikely respond to H. pylori eradication. 63 In addition to chromosomal translocation, BCL10 is also targeted by gene amplification, which has been observed in pancreatic cancers 64 and a single case of nodal diffuse large 66,[68][69][70] By retrospective study of a large cohort of MALT lymphoma, we have shown that the translocation mainly occurs in those from the liver (17%), lung (9%) and ocular adnexa (7%), but not in those from the salivary gland, thyroid and skin (Fig.…”
Section: Chromosomal Translocations T(11;18)(q21;q21)mentioning
confidence: 94%
“…48 Most of the t(1;14) positive cases are diagnosed at advanced stages. 63 Our recent study indicates that gastric MALT lymphoma with t(1;14)/strong BCL10 nuclear expression is most unlikely respond to H. pylori eradication. 63 In addition to chromosomal translocation, BCL10 is also targeted by gene amplification, which has been observed in pancreatic cancers 64 and a single case of nodal diffuse large 66,[68][69][70] By retrospective study of a large cohort of MALT lymphoma, we have shown that the translocation mainly occurs in those from the liver (17%), lung (9%) and ocular adnexa (7%), but not in those from the salivary gland, thyroid and skin (Fig.…”
Section: Chromosomal Translocations T(11;18)(q21;q21)mentioning
confidence: 94%
“…Clinically, gastric MALT lymphomas with t (11;18) or t (1;14) are significantly associated with advanced stages and resistance to H. pylori eradication. 14,15 Histologically, t(11;18)-positive MALT lymphomas seem to be more monotonous, lacking apparent transformed blasts. 16 These distinct clinico-pathological characteristics may indicate important differences in molecular mechanisms between MALT lymphomas with and without translocation.…”
Section: Introductionmentioning
confidence: 99%
“…These include deep penetration of the gastric wall, a t(11;18)(q21;q21) strong nuclear staining for BCL10 and lack of underlying H. pylori infection. [29][30][31][32] Depth of invasion of the wall and the presence of the translocation may not be independent predictors of response as lymphomas with deep mural extension at presentation frequently are positive for the translocation. 33 Following eradication therapy, examination of subsequent biopsies for regression of the tumour is essential.…”
Section: Extranodal Marginal Zone Lymphoma Of Mucosa-associated Lymphmentioning
confidence: 99%