Strong ion and weak acid analysis in severe preeclampsia: potential clinical significance

Ortner, Clemens; Combrinck, B.; Allie, Shaazia; Story, David A; Landau, Ruth; Cain, Kevin C.; Dyer, Robert A.

doi:10.1093/bja/aev221

Cited by 9 publications

(7 citation statements)

References 40 publications

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“…Stewarts approach has also been adopted for greater understanding of preeclampsia. One study performed acid-base analysis by the Stewart-Gilfix approach in healthy pregnant women and women with preeclampsia (90). A conventional analysis would not have revealed any dissimilarities as base excess was similar in both groups, but the difference in metabolic components became apparent when adopting the Stewart-Gilfix approach.…”

Section: Interpretation According To Stewart Of Pregnancy Induced Chamentioning

confidence: 99%

“…The application of Stewart´s principles also to analysis of physiological changes of pregnancy would increase understanding and acceptance when Stewart´s principles are applied to study pathological conditions. One recent study showed how analysis according to Stewart-Gilfix could offer predictive information in preeclamptic women (90).…”

Section: Paper 4 Feto-maternal Osmotic Relationshipmentioning

confidence: 99%

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Feto-maternal osmotic balance at term. A prospective observational study

Moen

Brudin

Tjernberg

et al. 2018

Journal of Perinatal Medicine

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Section: Interpretation According To Stewart Of Pregnancy Induced Chamentioning

confidence: 99%

Section: Paper 4 Feto-maternal Osmotic Relationshipmentioning

confidence: 99%

Feto-maternal osmotic balance at term. A prospective observational study

Moen

Brudin

Tjernberg

et al. 2018

Journal of Perinatal Medicine

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“…The presence of a significant metabolic alkalosis did not seem to overtly endanger the life of the patient as the mortality rates were similar in each group though, once again, the study numbers were relatively small. Finally, a low serum albumin, a common finding in critically ill patients, also contributed to the resultant acidbase disturbance by worsening any metabolic alkalosis [12][13][14] .…”

Section: Primary End Pointmentioning

confidence: 99%

A Comparison between Two Dilute Citrate Solutions (15 vs. 18 mmol/l) in Continuous Renal Replacement Therapy: The Base Excess and Renal Substitution Solution Study

Anstey

Campbell²,

Richardson

2016

Blood Purif

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Background/Aims: The study aimed to compare the changes in biochemistry occurring in patients undergoing continuous renal replacement therapy (CRRT) using 2 trisodium citrate solutions, Baxter hemofiltration fluid containing 18 mmol/l (C18) and Baxter NamSol, a custom manufactured solution containing 15 mmol/l (C15), both delivered as regional citrate anticoagulation (RCA) predilution fluids for hemofiltration. Methods: This is a prospective randomized control trial conducted in a major regional adult intensive care unit. Patients were randomized to 1 of 2 RCA fluids. Progress was monitored using a standard daily panel of acid-base and biochemical tests. Results: Forty-eight patients, 23 C18 and 25 C15, were recruited. In both groups, acidosis resolved within 36 h of institution of CRRT. By day 3, there were significant differences in serum [Na⁺], standard base excess and serum bicarbonate concentration, all being higher in the C18 group (p < 0.01). By day 5, the PaCO₂ had also risen in the C18 group (p = 0.03). Conclusions: The C15 solution provided equivalent filter life to the C18 solution but without significant hypernatremia and metabolic alkalosis.

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“…El exceso o déficit de bases (EDB) se define como la cantidad de ácido o base fuerte necesaria para que el pH retorne a un valor de 7,4 a un valor de presión parcial de CO 2 en sangre arterial de 40 mmHg y a 37 °C de temperatura (14,15). Es más sensible para identificar hipoperfusión que el pH y el bicarbonato, sobre todo en pacientes de trauma, donde cuenta con más estudios.…”

Section: Introductionunclassified

Asociación entre los niveles de déficit de base y la aparición de disfunción orgánica múltiple en pacientes con preeclampsia severa admitidas en la clínica gestión salud s.a.s (Cartagena) entre el 1 de enero de 2014 hasta 31 diciembre 2016

Villalba¹,

Coronado²

2017

Biociencias

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Objetivo: Determinar la asociación entre los niveles de déficit de base y la aparición de disfunción orgánica en pacientes con preeclampsia severa admitidas en la Clínica Gestión salud S.A.S (Cartagena) entre el 1 de enero de 2014 hasta 31 Dic 2016. Método: La Pseudomonas Aerugiosa es una bacilo gramnegativos, con diámetros de 1 - 3 mm de longitud, aerobio obligado, oxidasa positiva que crece a 37-42 °C, de habita variable (tierra, agua, plantas y animales). Se caracteriza por formar colonias redondeadas, lisas con olor a uvas y de variable color según el pimento producidos por la cepa color verde-azulado (piocinina y pioverdina), rojo oscuro (piorrubina) y negro (piomelanina). Resultados: Mediante un análisis de regresión logística se exploró la fuerza de asociación entre tener un déficit de base menor o igual a -5 y el desarrollo de DOM encontrándose una asociación estadísticamente significativa. Tener un déficit de base menor o igual a -5 aumentaba la probabilidad de desarrollar DOM con una OR de 3,73 (IC 95% 1,28 a 12,05 p=0,0197). Conclusión: Valores de DB menores a -5, es decir, tener un mayor DB se asocia a un aumento en la probabilidad de tener DOM. En este grupo de pacientes también son más frecuentes la disfunción hepática, la disfunción de la coagulación y el síndrome de HELLP.

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Strong ion and weak acid analysis in severe preeclampsia: potential clinical significance

Abstract: clinicaltrials.gov: NCT 02164370.

Cited by 9 publications

References 40 publications

Feto-maternal osmotic balance at term. A prospective observational study

Feto-maternal osmotic balance at term. A prospective observational study

A Comparison between Two Dilute Citrate Solutions (15 vs. 18 mmol/l) in Continuous Renal Replacement Therapy: The Base Excess and Renal Substitution Solution Study

Asociación entre los niveles de déficit de base y la aparición de disfunción orgánica múltiple en pacientes con preeclampsia severa admitidas en la clínica gestión salud s.a.s (Cartagena) entre el 1 de enero de 2014 hasta 31 diciembre 2016

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