Strong links between load and manure and a comprehensive risk assessment of veterinary antibiotics with low KOW in intensive livestock farming watersheds

Lee, Hyun-Jeoung; Kim, Deok Woo; Chung, Eu Gene

doi:10.1016/j.chemosphere.2021.130902

Cited by 12 publications

(7 citation statements)

References 47 publications

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“…The following supporting information can be downloaded at: , Figure S1: Adsorption percentage of TMP and its metabolites with different soil:solution ratio; Figure S2: Adsorption kinetic fitted to a pseudo-first-order model; Figure S3: Adsorption kinetic fitted to a pseudo-second-order model; Figure S4: Adsorption kinetic fitted to the Weber–Morris model; Figure S5: Adsorption kinetic on the IPD model according to equation q t / q ref vs. t/t ref ; Table S1: Matrix correlation of TMP and its metabolites adsorption and desorption with soil characteristics; Table S2: Physical and chemical properties of the target compounds; Table S3: LC-MS/MS parameters [ 38 , 39 , 40 ]; Table S4: Limits of detection (LOD) and quantitation (LOQ), accuracy (%), and precision (expressed as relative standard deviation ( n = 3)); Table S5: Adsorption and desorption isotherm models studied; Table S6: Adsorption kinetic models studied.…”

mentioning

confidence: 99%

Thermodynamic and Kinetic Investigation of the Adsorption and Desorption of Trimethoprim and Its Main Metabolites in Mediterranean Crop Soils

Mejías¹,

Santos²,

Martín³

et al. 2023

Molecules

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The adsorption–desorption processes of organic pollutants into the soil are one of the main factors influencing their potential environmental risks and distribution in the environment. In the present work, the adsorption–desorption behavior of an antibiotic, trimethoprim (TMP), and two of its main metabolites, 3-desmethyltrimethoprim (DM-TMP) and 4-hydroxytrimethoprim (OH-TMP), were assessed in three Mediterranean agricultural soils with different physicochemical characteristics. Results showed that the adsorption kinetic is performed in two steps: external sorption and intraparticle diffusion. The adsorptions of the studied compounds in soils were similar and fitted to the three models but were better fitted to a linear model. In the case of DM-TMP and OH-TMP, their adsorptions were positively correlated with the soil organic matter. In addition, desorption was higher in less organic matter soil (from 1.3 to 30.9%). Furthermore, the desorptions measured for the TMP metabolites were lower than those measured in the case of TMP (from 2.0 and 4.0% for OH-TMP and DM-TMP, respectively, to 9.0% for TMP).

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confidence: 99%

Thermodynamic and Kinetic Investigation of the Adsorption and Desorption of Trimethoprim and Its Main Metabolites in Mediterranean Crop Soils

Mejías¹,

Santos²,

Martín³

et al. 2023

Molecules

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“…Although the octanol water partitioning coefficient (Kow) is not the only factor that influences biologic activity of a compound (Dearden, 1985;Tamaian et al, 2015) there are others, for example, solubility and molecule size. Nevertheless, the significantly higher log Kow for CIP 1.32 (Zambrano et al, 2021) in comparison with the other two compounds (SULF: − 0.09 (Zambrano et al, 2021) and TRIM: 0.91 (Lee et al, 2021)) might play some role in the observation of mayor alterations in the organisms exposed to CIP in relation to those observed under SULF and TRIM exposure. However, bioaccumulation was not assessed within the framework of this work and further studies that consider uptake kinetics and body or tissue burdens should be carried out to confirm the contribution of the lipophilicity of compounds to their toxic potential.…”

Section: Discussionmentioning

confidence: 87%

The antibacterials ciprofloxacin, trimethoprim and sulfadiazine modulate gene expression, biomarkers and metabolites associated with stress and growth in gilthead sea bream (Sparus aurata).

Fernandez

Colás-Ruiz²,

Martı́nez-Rodrı́guez³

et al. 2022

Aquatic Toxicology

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“…To calculate the risk quotient (RQ), the maximum concentrations of antibiotics for each sampling time and point were divided by the predicted no-effect concentration (PNEC) [3,19,29], and the PNEC values derived by Lee (2021) were used for ecological risk assessment [5]. Additionally, the PNEC values for the antibiotic resistance risk assessment reported in many studies were used [19,22,30].…”

Section: Risk Assessmentmentioning

confidence: 99%

“…The two types of PNEC values obtained for the antibiotics are shown in Table 1. The values of PNEC for target antibiotics derived by a [5]; b [22]; c [19]; d [30].…”

Section: Risk Assessmentmentioning

confidence: 99%

“…Antibiotics are deemed indispensable for the protection of human life, and both their production and usage continue to increase steadily [1][2][3]. Furthermore, the consumption of meat has increased with the improved standards of living, and thus livestock breeding facilities have been scaled up in numerous regions to meet the growing demand [2,4,5]; consequently, considerable quantities of antibiotics are being used to prevent and treat diseases of livestock and to promote growth. According to the Korea Health Industry Development Institute, the quantity of national antibiotic production has continuously increased, and the market size was estimated at approximately KRW 1.1 trillion (USD ~950 million) in 2015 [1,6].…”

Section: Introductionmentioning

confidence: 99%

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Concentrations and Risk Assessments of Antibiotics in an Urban–Rural Complex Watershed with Intensive Livestock Farming

Lee

Kim

Kim³

et al. 2021

IJERPH

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Antibiotics used for the treatment of humans and livestock are released into the environment, whereby they pose a grave threat to biota (including humans) as they can cause the emergence of various strains of resistant bacteria. An improved understanding of antibiotics in the environment is thus vital for appropriate management and mitigation. Herein, surface water and groundwater samples containing antibiotics were analyzed in an urban–rural complex watershed (Cheongmi Stream) comprising intensive livestock farms by collecting samples across different time points and locations. The spatiotemporal trends of the residual antibiotics were analyzed, and ecological and antibiotic resistance-based risk assessments were performed considering their concentrations. The results showed that the concentrations and detection frequencies of the residual antibiotics in the surface water were affected by various factors such as agricultural activities and point sources, and were higher than those found in groundwater; however, frequent detection of antibiotics in groundwater showed that residual antibiotics were influenced by factors such as usage pattern and sewage runoff. Furthermore, few antibiotics posed ecological risks. The risk assessment methods adopted in this study can be applied elsewhere, and the results can be considered in the environmental management of residual antibiotics in the Cheongmi Stream watershed.

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Strong links between load and manure and a comprehensive risk assessment of veterinary antibiotics with low KOW in intensive livestock farming watersheds

Cited by 12 publications

References 47 publications

Thermodynamic and Kinetic Investigation of the Adsorption and Desorption of Trimethoprim and Its Main Metabolites in Mediterranean Crop Soils

Thermodynamic and Kinetic Investigation of the Adsorption and Desorption of Trimethoprim and Its Main Metabolites in Mediterranean Crop Soils

The antibacterials ciprofloxacin, trimethoprim and sulfadiazine modulate gene expression, biomarkers and metabolites associated with stress and growth in gilthead sea bream (Sparus aurata).

Concentrations and Risk Assessments of Antibiotics in an Urban–Rural Complex Watershed with Intensive Livestock Farming

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