2011
DOI: 10.1186/1746-1596-6-108
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Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification

Abstract: BackgroundPrognostic and predictive significance of epidermal growth factor receptor (EGFR) in colorectal carcinomas (CRCs) is still controversial. The aim of the present study was to explore and correlate membrane and nuclear EGFR and cyclin-D1 protein expression with EGFR gene status of tumor cells.MethodsImmunohistochemical and FISH analysis was performed on 135 archival formalin fixed and paraffin embedded CRCs.ResultsStrong membrane and strong nuclear EGFR staining was detected in 16% and 57% of cases, re… Show more

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Cited by 19 publications
(18 citation statements)
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“…Usually, RCTs express high levels of EGFR [1,2], a finding that is recurrent also in other subgroups of highly aggressive CRCs . These results suggest that a combined assessment of CDX2, Vimentin and EGFR may be of clinical value to make a differential diagnosis, to predict a poor patients’ outcome or to choose the best fit biological therapy [17,18]. INI1 loss-of-function mutations have been identified in pediatric MRTs, whereas their role in adult extra-renal rhabdoid tumors is still elusive [5,6].…”
Section: Discussionmentioning
confidence: 99%
“…Usually, RCTs express high levels of EGFR [1,2], a finding that is recurrent also in other subgroups of highly aggressive CRCs . These results suggest that a combined assessment of CDX2, Vimentin and EGFR may be of clinical value to make a differential diagnosis, to predict a poor patients’ outcome or to choose the best fit biological therapy [17,18]. INI1 loss-of-function mutations have been identified in pediatric MRTs, whereas their role in adult extra-renal rhabdoid tumors is still elusive [5,6].…”
Section: Discussionmentioning
confidence: 99%
“…to therapy, tumour aggressiveness and poor survival (37)(38)(39)(40)(41)(42)(43). This demonstrates the complex mechanisms by which HER signalling may be activated and the need for further studies to unravel the role of nuclear HER family members in the proliferation and progression of tumour cells as wells as its potential as a prognostic marker, predictive biomarker and therapeutic target in colorectal cancer patients (39,40,(44)(45)(46)(47). Abbreviations: IHC Immunohistochemistry, FISH fluorescence in situ hybridisation, CISH chromogenic in situ hybridisation, RT-PCR real-time polymerase chain reaction, AR amphiregulin, EPI epiregulin, met metastatic…”
Section: This Issue)mentioning
confidence: 99%
“…wild-type, mutated, soluble, phosphorylated EGFR) and their cellular locations (e.g. cytoplasmic, membranous or nuclear) and such studies should be conducted on a larger group of patients using a standard scoring system (39,40,44,56,(68)(69)(70)(71).…”
Section: Expression Pattern and Prognostic Significance Of Egfr And Imentioning
confidence: 99%
“…Na mijelomskim stanicama analizirana je ekspresija ciklina D1, a sve u cilju predikcije odgovora na terapiju s bortezomibom. Pretpostavka je bila da će ekspresija biti udružena s boljom prognozom kao što su to dosadašnja istraživanja pokazala za karcinom dojke gdje je ekspresija ciklina D1 u premenopauzalnih pacijentica korelirala s dužim preživljenjem 2 , ili u kolorektalnom karcinomu gdje je udružena ekspresija nuklearnog EGFR-a i ciklina D1 imala kliničku implikaciju 3 . U sklopu mikrookoliša multiplog mijeloma istraživana je angiogeneza.…”
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