Strontium Substituted Tricalcium Phosphate Bone Cement: Short and Long‐Term Time‐Resolved Studies and In Vitro Properties

Rau, Julietta V.; Фадеева, И. В.; Forysenkova, Anna A.; Давыдова, Г. А.; Fosca, Marco; Filippov, Ya. Yu.; Antoniac, Iulian; Antoniac, Aurora; D’Arco, Annalisa; Fabrizio, Marta Di; Petrarca, M.; Lupi, S.; Bucchianico, Massimo Di Menno Di; Yankova, V.G.; Putlayev, V.I.; Cristea, M

doi:10.1002/admi.202200803

Cited by 18 publications

(9 citation statements)

References 76 publications

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“…CaP is available in the form of cements [ 12 ], granules [ 13 ] or powders [ 14 ]. CaP may contain substituting ions [ 15 , 16 , 17 ] to impart osteoinductive (Sr) [ 18 ] or antibacterial (Cu, Zn, Ag, Mn, Gd) [ 19 , 20 , 21 , 22 , 23 ] properties. For dental applications, carbonate hydroxyapatite (CHA, Ca 10 (PO 4 ) 6 (CO 3 ) 0.5 (OH) is a good choice, because of its similar composition to the mineral component of dentin [ 24 ].…”

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confidence: 99%

Polyvinylpyrrolidone—Alginate—Carbonate Hydroxyapatite Porous Composites for Dental Applications

et al. 2023

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An alternative approach for the currently used replacement therapy in dentistry is to apply materials that restore tooth tissue. Among them, composites, based on biopolymers with calcium phosphates, and cells can be applied. In the present work, a composite based on polyvinylpyrrolidone (PVP) and alginate (Alg) with carbonate hydroxyapatite (CHA) was prepared and characterized. The composite was investigated by X-ray diffraction, infrared spectroscopy, electron paramagnetic resonance (EPR) and scanning electron microscopy methods, and the microstructure, porosity, and swelling properties of the material were described. In vitro studies included the MTT test using mouse fibroblasts, and adhesion and survivability tests with human dental pulp stem cells (DPSC). The mineral component of the composite corresponded to CHA with an admixture of amorphous calcium phosphate. The presence of a bond between the polymer matrix and CHA particles was shown by EPR. The structure of the material was represented by micro- (30–190 μm) and nano-pores (average 8.71 ± 4.15 nm). The swelling measurements attested that CHA addition increased the polymer matrix hydrophilicity by 200%. In vitro studies demonstrated the biocompatibility of PVP-Alg-CHA (95 ± 5% cell viability), and DPSC located inside the pores. It was concluded that the PVP-Alg-CHA porous composite is promising for dentistry applications.

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Section: Introductionmentioning

confidence: 99%

Polyvinylpyrrolidone—Alginate—Carbonate Hydroxyapatite Porous Composites for Dental Applications

et al. 2023

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“…Typical THz TDS instruments enable the investigation in the frequency range from 0.1 to 4 THz, approximately [ 22 ]. It is a fast and non-destructive method that can be used in several research areas, such as medicine, engineering, material sciences and chemistry [ 22 , 23 , 24 , 25 ]. In reference [ 26 ] a comprehensive overview of THz science and technology as well as numerous fields of applications is given.…”

Section: Introductionmentioning

confidence: 99%

Terahertz Spectroscopy for Non-Destructive Solid-State Investigation of Norfloxacin in Paper Tablets after Wet Granulation

et al. 2023

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(1) Background: Amorphous drug systems are an intensively studied approach to overcome the insufficient bioavailability of poorly soluble drugs. Here, paper tablets were studied, which were made from cellulose-based paper matrices loaded with norfloxacin. Moreover, wet granulation was introduced as an additional processing step for improving the flowability of the solids, which is necessary when considering production on an industrial scale. (2) Methods: The possible impact of the wet granulation on the crystallinity of norfloxacin was studied by examining granulated and non-granulated samples. Crystallinity investigations were performed using X-ray powder diffraction (XRD) and terahertz time-domain spectroscopy (THz TDS). (3) Results: THz TDS allowed for a more straightforward crystallinity assessment than XRD. Moreover, using THz TDS, it was possible to detect minor changes in the crystallinity of the API after the granulation, whereas this was not possible with the XRD analysis. (4) Conclusions: THz TDS results indicate a partial crystallization of norfloxacin due to the wet granulation. Depending on the formulation, THz TDS can serve as a beneficial and advantageous tool to determine the crystallinity of an API.

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“…Nowadays, due to stress and inadequate nutrition, the health of a considerable number of people is severely affected by cardiovascular disease and diabetes, which in their advanced stages can lead to unmanageable complications. Additionally, the problem of infections that can appear after a surgical intervention is important in all medical fields, such as orthopedics [ 1 , 2 , 3 , 4 , 5 , 6 ], dentistry [ 7 , 8 ], neurosurgery [ 9 , 10 ], or general surgery [ 11 , 12 , 13 , 14 , 15 ]. Ulcers in the case of stroke or pressure ulcers due to diabetes constitute the third most expensive disease.…”

Section: Introductionmentioning

confidence: 99%

Essential Oils as Antimicrobial Active Substances in Wound Dressings

et al. 2022

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Wound dressings for skin lesions, such as bedsores or pressure ulcers, are widely used for many patients, both during hospitalization and in subsequent treatment at home. To improve the treatment and shorten the healing time and, therefore, the cost, numerous types of wound dressings have been developed by manufacturers. Considering certain inconveniences related to the intolerance of some patients to antibiotics and the antimicrobial, antioxidant, and curative properties of certain essential oils, we conducted research by incorporating these oils, based on polyvinyl alcohol/ polyvinyl pyrrolidone (PVA/PVP) biopolymers, into dressings. The objective of this study was to study the potential of a polymeric matrix for wound healing, with polyvinyl alcohol as the main material and polyvinyl pyrrolidone and hydroxypropyl methylcellulose (HPMC) as secondary materials, together with additives (plasticizers poly(ethylene glycol) (PEG) and glycerol), stabilizers (Zn stearate), antioxidants (vitamin A and vitamin E), and four types of essential oils (fennel, peppermint, pine, and thyme essential oils). For all the studied samples, the combining compatibility, antimicrobial, and cytotoxicity properties were investigated. The obtained results demonstrated a uniform morphology for almost all the samples and adequate barrier properties for contact with suppurating wounds. The results show that the obtained samples containing essential oils have a good inhibitory effect on, or antimicrobial properties against, Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, and Candida albicans ATCC 10231. The MTT assay showed that the tested samples were not toxic and did not lead to cell death. The results showed that the essential oils used provide an effective solution as active substances in wound dressings.

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Strontium Substituted Tricalcium Phosphate Bone Cement: Short and Long‐Term Time‐Resolved Studies and In Vitro Properties

Abstract: in the study mode λ ex = 546 nm, λ emiss = 575-640 nm. Results related to specific cement (TCP and Sr-TCP) were used to calculate mean values and correspondent mean square errors as reported in Figure 18.

Cited by 18 publications

References 76 publications

Polyvinylpyrrolidone—Alginate—Carbonate Hydroxyapatite Porous Composites for Dental Applications

Polyvinylpyrrolidone—Alginate—Carbonate Hydroxyapatite Porous Composites for Dental Applications

Terahertz Spectroscopy for Non-Destructive Solid-State Investigation of Norfloxacin in Paper Tablets after Wet Granulation

Essential Oils as Antimicrobial Active Substances in Wound Dressings

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