Structural Abnormalities of Chromosome 2 in Benign Thyroid Tumors

Bol, Silvia; Belge, Gazanfer; Thode, Brita; Bartnitzke, Sabine; Bullerdiek, Jörn

doi:10.1016/s0165-4608(99)00028-x

Cited by 19 publications

(13 citation statements)

References 12 publications

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“…Chromosome 2p21 aberrations characterize the second most frequent structural chromosomal rearrangements in benign adenomas of the thyroid (Belge et al, 1998;Bol et al, 1999). From the results presented herein, there is little doubt that THADA is indeed the target gene of those translocations.…”

Section: Discussionmentioning

confidence: 56%

“…There are two chromosomal bands most frequently rearranged by these translocations, that is, 19q13 (Bartnitzke et al, 1989;Bondeson et al, 1989;Dal Cin et al, 1992;Belge et al, 1998) and 2p21 (Teyssier et al, 1990;Belge et al, 1998;Bol et al, 1999). Both types of translocations apparently do not co-occur in thyroid tumors, thus indicating two independent cytogenetic subgroups.…”

Section: Introductionmentioning

confidence: 99%

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Identification of a gene rearranged by 2p21 aberrations in thyroid adenomas

et al. 2003

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Thyroid adenomas belong to the cytogenetically best investigated human epithelial tumors. Cytogenetic studies of about 450 benign lesions allow one to distinguish between different cytogenetic subgroups. Two chromosomal regions, that is, 19q13 and 2p21, are frequently rearranged in these tumors. Although 2p21 aberrations only account for about 10% of the benign thyroid tumors with clonal cytogenetic deviations, 2p21 rearrangements belong to the most common cytogenetic rearrangements in epithelial tumors due to the high frequency of these benign lesions. The 2p21 breakpoint region recently has been delineated to a region of 450 kbp, but the gene affected by the cytogenetic rearrangements still has escaped detection. Positional cloning and 3 0 RACE-PCR allowed us to clone that gene which we will refer to as thyroid adenoma associated (THADA) gene. In cells from two thyroid adenomas characterized by translocations t(2;20;3) (p21;q11.2;p25) and t(2;7)(p21;p15), respectively, we performed 3 0 -RACE-PCRs and found two fusions of THADA with a sequence derived from chromosome band 3p25 or with a sequence derived from chromosome band 7p15. The THADA gene spans roughly 365 kbp and, based on preliminary results, encodes a death receptorinteracting protein.

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Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Identification of a gene rearranged by 2p21 aberrations in thyroid adenomas

et al. 2003

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“…Nonrandom abnormalities of chromosome 2 were also observed. In this subgroup aberrations involving 2p21 represent the most frequent finding (Bol et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…In thyroid adenomas and hyperplasias chromosome aberrations involving chromosome 2 have been repeatedly described in the literature (Bondeson, et al, 1989;Teyssier and Ferre, 1989;Teyssier et al, 1990;Sozzi et al, 1992;Antonini et al, 1993;Roque et al, 1993;Belge et al, 1996Belge et al, , 1998Bol et al, 1999). Three breakpoint clusters have been identified, i.e.…”

confidence: 91%

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Molecular cytogenetic investigations define a subgroup of thyroid adenomas with 2p21 breakpoints clustered to a region of less than 450 kb

Bol

Belge

Rippe

et al. 2001

Cytogenet Genome Res

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Structural rearrangements involving chromosome band 2p21 characterize a cytogenetic subgroup of benign thyroid tumors. To narrow down the breakpoints of these aberrations, we established two cell lines from benign thyroid tumors showing translocations involving 2p21. These two cell lines and one additional primary tumor were used for FISH-studies with 18 BAC clones. All breakpoints were mapped to a cluster of about 450 kb.

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Molecular Events in Follicular Thyroid Tumors

Kroll

Cancer Treatment and Research

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Structural Abnormalities of Chromosome 2 in Benign Thyroid Tumors

Cited by 19 publications

References 12 publications

Identification of a gene rearranged by 2p21 aberrations in thyroid adenomas

Identification of a gene rearranged by 2p21 aberrations in thyroid adenomas

Molecular cytogenetic investigations define a subgroup of thyroid adenomas with 2p21 breakpoints clustered to a region of less than 450 kb

Molecular Events in Follicular Thyroid Tumors

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