Structural alterations of the brain preceded functional alterations in major depressive disorder patients: Evidence from multimodal connectivity

Yao, Zhijun; Zou, Ying; Zheng, Weihao; Zhang, Zhe; Li, Yuan; Yu, Yue; Zhang, Zicheng; Fu, Yu; Shi, Jie; Zhang, Wenwen; Wu, Xia; Hu, Bin

doi:10.1016/j.jad.2019.04.064

Cited by 62 publications

(47 citation statements)

References 82 publications

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“…Being more effective than other network properties to measure network integration performance, global efficiency of the FN and SN were utilized to explore network resilience quantitatively [32]. In the present study, both networks of RC patients were more vulnerable and SN is less resilient than FN, which were consistent with our previous research results [61]. This finding enhanced the conclusion that lower brain resilience was associated with progressive deterioration of cognitive impairment in breast cancer survivors [19].…”

Section: The Difference Of Network Resiliencesupporting

confidence: 91%

Abnormal Functional and Structural networks in Rectal Cancer with Depressive risk: A Graph Theory Analysis

Zhang

Zou

et al. 2019

Preprint

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Background: Surgery and chemotherapy can cause depressive risk in patients with rectal cancer (RC). However, few comprehensive studies are conducted on RC patients associated alterations induced by emotional disorders in the topological organization of structural and functional networks. Methods: Resting-state functional MRI and Diffusion tensor imaging data were collected from 36 RC patients with surgery and chemotherapy and 32 healthy controls (HC). Functional network (FN) was constructed from extracting average time courses for 246 regions of interest (ROI) and structural network (SN) was established by deterministic tractography. Graph theoretical analysis was used to calculate small-worldness property, clustering coefficients, shortest path length and network efficiency. Additionally, we assess network resilient on FN and SN. Results: Abnormal small-worldness property of FN and SN were found in RC patients. The FN and SN exhibited increased local efficiency and global efficiency respectively in RC patients.The increased nodal efficiency in RC patients were mainly found in the frontal lobe, parietal lobe and limbic lobe for FN and SN, while the decreased nodal efficiency were distributed in subcortical nuclei, parietal lobe and limbic lobe only for SN. In network resilient analysis, the RC patients showed less resilient to targeted or random node deletion in both networks compared with HC. Moreover, FN is more robust than SN for all participants. Conclusions: This study revealed that topological organizations of the FN and SN may be disrupted in RC patients. Brain network reorganization is a compensation mechanism to alleviate the depressive risk in RC patients after surgery and chemotherapy.

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Section: The Difference Of Network Resiliencesupporting

confidence: 91%

Abnormal Functional and Structural networks in Rectal Cancer with Depressive risk: A Graph Theory Analysis

Zhang

Zou

et al. 2019

Preprint

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“…Being more effective than other network properties to measure network integration performance, global efficiency of the FN and SN were utilized to explore network resilience quantitatively [30]. In the present study, both networks of RC patients were more vulnerable and SN is less resilient than FN, which were consistent with our previous research results [57]. This finding enhanced the conclusion that lower brain resilience was associated with progressive deterioration of cognitive impairment in breast cancer survivors [17].…”

Section: The Difference Of Network Resiliencesupporting

confidence: 91%

Abnormal Functional and Structural networks in Rectal Cancer with Depressive symptoms: A Graph Theory Analysis

Zhang

Zou

et al. 2019

Preprint

Self Cite

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Background: Surgery and chemotherapy can cause emotional disorders in patients with rectal cancer (RC). However, few comprehensive studies are conducted on RC patients associated alterations in the topological organization of structural and functional networks. Methods: Resting-state functional MRI and Diffusion tensor imaging data were collected from 36 RC patients with surgery and chemotherapy and 32 healthy controls (HC). Functional network (FN) was constructed from extracting average time courses for 246 regions of interest (ROI) and structural network (SN) was established by deterministic tractography. Graph theoretical analysis was used to calculate small-worldness property, clustering coefficients, shortest path length and network efficiency. Additionally, we assess network resilient on FN and SN. Results: Abnormal small-worldness property of FN and SN were found in RC patients. The FN and SN exhibited increased local efficiency and global efficiency respectively in RC patients.The increased nodal efficiency in RC patients were mainly found in the frontal lobe, parietal lobe and limbic lobe for FN and SN, while the decreased nodal efficiency were distributed in subcortical nuclei, parietal lobe and limbic lobe only for SN. In network resilient analysis, the RC patients showed less resilient to targeted or random node deletion in both networks compared with HC. Moreover, FN is more robust than SN for all participants. Conclusions: This study revealed that topological organizations of the FN and SN may be disrupted in RC patients. Brain network reorganization is a compensation mechanism for brain impairment after surgery and chemotherapy.

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“…Both structural and functional abnormalities in the temporal lobe show high discriminative power in distinguishing MDD patients from HCs (12). Besides, decreased nodal efficiency and thinner cortical gray matter in the temporal lobe have been found in MDD compared with HCs in cross-sectional studies (10,46). Whereas, thicker cortical thickness in the temporal cortex in remitters than in non-remitters (47), and normalization of the temporal cortex activity with treatment (48) were found.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, many previous studies had found decreased inter-regional SC in the temporal-limbic, frontolimbic, and parietal-limbic circuits in MDD patients relative to HCs (4,(7)(8)(9). Recently, reduced connections related to the superior temporal gyrus, both for functional and structural connectivity, were also found in MDD patients relative to HCs (10). After electroconvulsive therapy, the decreased SCs among the temporal, frontal lobe, and limbic structures in MDD patients were reversed (11).…”

Section: Introductionmentioning

confidence: 95%

State-Independent and -Dependent Structural Connectivity Alterations in Depression

et al. 2020

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Some brain abnormalities persist at the remission phase, that is, the state-independent abnormalities, which may be one of the reasons for the high recurrence of major depressive disorder (MDD). Hence, it is of great significance to identify state-independent abnormalities of MDD through longitudinal investigation. Ninety-nine MDD patients and 118 healthy controls (HCs) received diffusion tensor imaging scanning at baseline. After 6-month antidepressant treatment, 68 patients received a second scan, among which 59 patients achieved full clinical remission. Differences in whole-brain structural connectivity (SC) between patients with MDD at baseline and HCs were estimated by two-sample t-tests. Masked with significantly changed SCs in MDD, two-sample t-tests were conducted between the remitted MDD subgroup at follow-up and HCs, and paired t-tests were implemented to compare the differences of SC in the remitted MDD subgroup before and after treatment. Significantly decreased SC between the right insula and the anterior temporal cortex (ATC), between the right ATC and the posterior temporal cortex (PTC), between the left ATC and the auditory cortex as well as increased connectivity between the right posterior cingulate cortex (PCC) and the left medial parietal cortex (MPC) were observed in the MDD group compared with the HC group at baseline (p < 0.05, FDR corrected). The decreased connectivity between the right insula and the ATC and increased connectivity between the right PCC and the left MPC persisted in the remitted MDD subgroup at follow-up (p < 0.05, FDR corrected). The decreased SC between the right insula and the ATC and increased SC between the right PCC and left MPC showed state-independent characters, which may be implicated in the sustained negative attention bias and motor retardation in MDD. In contrast, the decreased SC between the right ATC and the PTC and between the left ATC and the auditory cortex seemed to be state-dependent.

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Structural alterations of the brain preceded functional alterations in major depressive disorder patients: Evidence from multimodal connectivity

Cited by 62 publications

References 82 publications

Abnormal Functional and Structural networks in Rectal Cancer with Depressive risk: A Graph Theory Analysis

Abnormal Functional and Structural networks in Rectal Cancer with Depressive risk: A Graph Theory Analysis

Abnormal Functional and Structural networks in Rectal Cancer with Depressive symptoms: A Graph Theory Analysis

State-Independent and -Dependent Structural Connectivity Alterations in Depression

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