Structural Analysis and Effects of Exopolysaccharide (LHEPS-3) from Lactobacillus helveticus MB2-1 on Human Hepatoma HepG-2 Cells: Inhibition of Proliferation, Migration and Angiogenesis

Wang, Xiaomeng; Ji, Juan; Xu, Mengjia; Rui, Xin; Zhang, Qiuqin; Dong, Mingsheng; Li, Wei

doi:10.1134/s1068162023030251

Russ J Bioorg Chem

2023

DOI: 10.1134/s1068162023030251

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Structural Analysis and Effects of Exopolysaccharide (LHEPS-3) from Lactobacillus helveticus MB2-1 on Human Hepatoma HepG-2 Cells: Inhibition of Proliferation, Migration and Angiogenesis

Xiaomeng Wang

Juan Ji

Mengjia Xu

et al.

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2024

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Natural products‐based antiangiogenic agents: New frontiers in cancer therapy

Azevedo,

Ferreira,

Peña‐Corona

et al. 2024

Food Frontiers

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Angiogenesis, vital for tumor growth and metastasis, is a promising target in cancer therapy. Natural compounds offer potential as antiangiogenic agents with reduced toxicity. This review provides a comprehensive overview of natural product‐based antiangiogenic therapies, focusing on molecular mechanisms and therapeutic potential. A systematic search identified relevant articles from 2019 to 2023. Various natural compounds, including polyphenols, terpenes, alkaloids, cannabinoids, omega‐3 fatty acids, polysaccharides, proteins, and carotenoids, were investigated for their antiangiogenic properties. Challenges such as dose standardization, routes of administration, and potential side effects remain. Further studies, including in‐depth animal models and human epidemiological studies, must elucidate clinical efficacy and safety. Synergistic effects with current antiangiogenic therapies, such as bevacizumab and tyrosine kinase inhibitors, should be explored. Additionally, the potential hormone‐dependent effects of compounds like genistein highlight the need for safety evaluation. In conclusion, natural products hold promise as adjunctive therapies to conventional antineoplastic drugs in modulating angiogenesis in cancer. However, robust clinical trials are needed to validate preclinical findings and ensure safety and efficacy.

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Natural products‐based antiangiogenic agents: New frontiers in cancer therapy

Azevedo,

Ferreira,

Peña‐Corona

et al. 2024

Food Frontiers

View full text Add to dashboard Cite

show abstract

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Structural Analysis and Effects of Exopolysaccharide (LHEPS-3) from Lactobacillus helveticus MB2-1 on Human Hepatoma HepG-2 Cells: Inhibition of Proliferation, Migration and Angiogenesis

Cited by 1 publication

References 28 publications

Natural products‐based antiangiogenic agents: New frontiers in cancer therapy

Natural products‐based antiangiogenic agents: New frontiers in cancer therapy

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