Structural and antibacterial properties of NSAID-loaded ultra-high molecular weight polyethylene

Gil, Dmitry; Hugard, Shannon; Grindy, Scott; Borodinov, Nikolay; Muratoglu, Orhun K.; Bedair, Hany; Oral, Ebru

doi:10.1016/j.mtla.2020.100662

Cited by 6 publications

(14 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tolfenamic acid and bupivacaine were incorporated into UHMWPE using the same method as described elsewhere to prepare single drug-loaded UHMWPE. 18 In our previous studies, we showed that phaseseparated compression molding can be used to prepare drug-eluting polymeric systems with highly eccentric drug clusters under these molding conditions. 15 The conditions used here were neither expected to cause chemical or structural degradation of the drugs, nor affect tolfenamic acid and bupivacaine antibacterial efficacy.…”

Section: Discussionmentioning

confidence: 99%

“…15 The conditions used here were neither expected to cause chemical or structural degradation of the drugs, nor affect tolfenamic acid and bupivacaine antibacterial efficacy. [16][17][18] Antibacterial activity of tolfenamic acid/bupivacaine-loaded UHMWPE was assessed against MSSA and S. epidermidis. In contrast to MSSA, the S. epidermidis strain was icaA positive, thus had a higher potency towards biofilm formation.…”

Section: Discussionmentioning

confidence: 99%

“…Previously we showed that ultra-high molecular weight polyethylene (UHMWPE) bearing surfaces, which are components of most total joint implant systems, can be used as delivery vehicles to provide sustained local release of various therapeutics, including antibiotics and analgesics. [15][16][17][18] Of particular interest are UHMWPE loaded with therapeutics that are not typically used as antibiotics, but have been shown to yield secondary antibacterial effects, while overcoming concerns about bacterial resistance. For example, multiple analgesics, including sodium-channel blockers and non-steroidal anti-inflammatory drugs (NSAIDs), were shown to possess antibacterial activity against bacterial pathogens associated with PJI.…”

Section: Introductionmentioning

confidence: 99%

“…16 Tolfenamic acid (NSAID)-loaded UHMWPE also yielded excellent antibacterial activity against various strains of Staphylococci. 18 These materials, designed to provide post-arthroplasty pain relief, can also be used as part of multi-modal antibacterial prophylaxis after primary arthroplasty. We further showed, for the first time, that various analgesics when used concurrently show synergistic antibacterial activity against Staphylococci.…”

Section: Introductionmentioning

confidence: 99%

“…In our previous study, we showed that UHMWPE loaded with bupivacaine (sodium‐channel blocker) exhibited pronounced antibacterial properties against methicillin‐sensitive S. aureus 16 . Tolfenamic acid (NSAID)‐loaded UHMWPE also yielded excellent antibacterial activity against various strains of Staphylococci 18 . These materials, designed to provide post‐arthroplasty pain relief, can also be used as part of multi‐modal antibacterial prophylaxis after primary arthroplasty.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Dual‐analgesic loadedUHMWPEexhibits synergistic antibacterial effects againstStaphylococci

et al. 2022

Self Cite

View full text Add to dashboard Cite

Total joint arthroplasty is one of the most common surgeries in the United States, with almost a million procedures performed annually. Periprosthetic joint infections (PJI) remain the most devastating complications associated with total joint replacement. Effective antibacterial prophylaxis after primary arthroplasty could substantially reduce incidence rate of PJI. In the present study we propose to provide post‐arthroplasty prophylaxis via dual‐analgesic loaded ultra‐high molecular weight polyethylene (UHMWPE). Our approach is based on previous studies that showed pronounced antibacterial activity of analgesic‐ and NSAID‐loaded UHMWPE against Staphylococci. Here, we prepared bupivacaine/tolfenamic acid‐loaded UHMWPE and assessed its antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis. Dual‐drug loaded UHMWPE yielded an additional 1–2 log reduction of bacteria, when compared with single‐drug loaded UHMWPE. Analysis of the drug elution kinetics suggested that the observed increase in antibacterial activity is due to the increased tolfenamic acid elution from dual‐drug loaded UHMWPE. We showed that the increased fractal dimension of the drug domains in UHMWPE could be associated with increased drug elution, leading to higher antibacterial activity. Dual‐analgesic loaded UHMWPE proposed here can be used as part of multi‐modal antibacterial prophylaxis and promises substantial reduction in post‐arthroplasty mortality and morbidity.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dual‐analgesic loadedUHMWPEexhibits synergistic antibacterial effects againstStaphylococci

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

Antibiotic‐Loaded Ultrahigh Molecular Weight Polyethylenes

Lekkala,

Inverardi,

Yuh

et al. 2024

Macromolecular Bioscience

Self Cite

View full text Add to dashboard Cite

The occurrence of periprosthetic joint infections (PJI) after total joint replacement constitutes a great burden for the patients and the healthcare system. Antibiotic‐loaded polymethylmethacrylate (PMMA) bone cement is often used in temporary spacers during antibiotic treatment. PMMA is not a load‐bearing solution and needs to be replaced by a functional implant. Elution from the ultra‐high molecular weight polyethylene (UHMWPE) bearing surface for drug delivery can combine functionality with the release of clinically relevant doses of antibiotics. In this study, the feasibility of incorporating a range of antibiotics into UHMWPE is investigated. Drug stability is assessed by thermo‐gravimetric analysis and nuclear magnetic resonance spectroscopy. Drug‐loaded UHMWPEs are prepared by compression molding, using eight antibiotics at different loading. The predicted intra‐articular concentrations of drugs eluted from UHMWPE are above minimum inhibitory concentration for at least three weeks against Staphylococci, which are the major causative bacteria for PJI. The antibacterial efficacy is confirmed for samples covering 2% of a representative knee implant in vitro over 72 hours, showing that a small fraction of the implant surface loaded with antibiotics might be sufficient against Staphylococci.This article is protected by copyright. All rights reserved

show abstract

Construction of a cross-bedded tea polyphenol delivery structure in ultrahigh molecular weight polyethylene against bacteria for joint replacement

Ren,

Lv,

Zhao

et al. 2024

Composites Science and Technology

View full text Add to dashboard Cite

Structural and antibacterial properties of NSAID-loaded ultra-high molecular weight polyethylene

Cited by 6 publications

References 41 publications

Dual‐analgesic loadedUHMWPEexhibits synergistic antibacterial effects againstStaphylococci

Dual‐analgesic loadedUHMWPEexhibits synergistic antibacterial effects againstStaphylococci

Antibiotic‐Loaded Ultrahigh Molecular Weight Polyethylenes

Construction of a cross-bedded tea polyphenol delivery structure in ultrahigh molecular weight polyethylene against bacteria for joint replacement

Contact Info

Product

Resources

About