Structural and dynamical characterization of poly-gamma-glutamic acid-based cross-linked nanoparticles

Radu, Judit Eva Fleischer; Novák, Levente; Hartmann, John F.; Beheshti, Neda; Kjøniksen, Anna–Lena; Nyström, Bo; Borbély, János

doi:10.1007/s00396-007-1776-8

Cited by 33 publications

(15 citation statements)

References 33 publications

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“…Covalent bonding interactions Vinyl [33,38,39,42] Radical coupling & Cross-Metathesis Benzocyclobutene [40,53] Diels-Alder reaction * Benzosulfone [9,28,41] Diels-Alder reaction * Azide + Protected alkyne [3,10,21,22,30,34] Copper-catalyzed [3+2] cycloaddition ** Carboxilic acid [54] Amide formation Isocyanate [23] Urea formation ** Enediyne [11,12,24,29] Bergman & Photo-Bergman cyclization Sulfonyl azide [31] Nitrene-mediated cross-linking Benzoxazine [36] Ring opening polymerization Alkyne [25] Glaser-Hay coupling * * C-C click chemistry. ** N-C click chemistry.…”

Section: Reactive Functional Groupsmentioning

confidence: 99%

Advances in Click Chemistry for Single-Chain Nanoparticle Construction

2013

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Single-chain polymeric nanoparticles are artificial folded soft nano-objects of ultra-small size which have recently gained prominence in nanoscience and nanotechnology due to their exceptional and sometimes unique properties. This review focuses on the current state of the investigations of click chemistry techniques for highly-efficient single-chain nanoparticle construction. Additionally, recent progress achieved for the use of well-defined single-chain nanoparticles in some promising fields, such as nanomedicine and catalysis, is highlighted.

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Section: Reactive Functional Groupsmentioning

confidence: 99%

Advances in Click Chemistry for Single-Chain Nanoparticle Construction

2013

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“…The poly--glutamic acid ( -PGA, = 1.2 × 10 6 , from GPC) was purchased from Nanjing Saitaisi Biotechnology Co. Ltd. (Nanjing, China); in the first step, nanoparticles (NPs) were created as previously described [30]. Water-soluble 1-[3-(dimethylamino) propyl]-3ethylcarbodiimide hydrochloride (EDC) (Carbosyth Limited, Compton, Berkshire, UK), 2,2 -(ethylenedioxy)bis(ethylamine) (98%) (EDA) as crosslinker, 2-aminoethyl methacrylate hydrochloride (90%) (AEM) as methacrylating agent, and ampicillin sodium salt as active substance were purchased from Sigma Aldrich (St. Louis, MO, USA).…”

Section: Modifications Of Pgamentioning

confidence: 99%

Poly-γ-Glutamic Acid Nanoparticles Based Visible Light-Curable Hydrogel for Biomedical Application

Bakó

Kerényi

Hrubi

et al. 2016

Journal of Nanomaterials

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Nanoparticles and hydrogels have gained notable attention as promising potential for fabrication of scaffolds and delivering materials. Visible light-curable systems can allow for the possibility ofin situfabrication and have the advantage of optimal applicability. In this study nanogel was created from methacrylated poly-gamma-glutamic acid nanoparticles by visible (dental blue) light photopolymerization. The average size of the particles was 80 nm by DLS, and the NMR spectra showed that the methacrylation rate was 10%. Polymerization time was 3 minutes, and a stable nanogel with a swelling rate of 110% was formed. The mechanical parameters of the prepared structure (compression stress 0.73 MPa, and Young’s modulus 0.93 MPa) can be as strong as necessary in a real situation, for example, in the mouth. A retaining effect of the nanogel was found for ampicillin, and the biocompatibility of this system was tested by Alamar Blue proliferation assay, while the cell morphology was examined by fluorescence and laser scanning confocal microscopy. In conclusion, the nanogel can be used for drug delivery, or it can be suitable for a control factor in different systems.

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“…[37][38][39][40][41] In order to achieve protein mimicry, besides controlling monomer sequence and chain folding, equipping SCNPs with different amino acids or peptide moieties further approaches the composition of natural proteins. SCNPs with protein-like characteristics can either be prepared through functional precursor polymers, as is the case with poly(γ-glutamic acid) precursors for example, [42][43][44] or by post-formation functionalization of SCNPs. [45][46][47] Post-formation functionalization enables modification of polymers, 48 nanoparticles 49,50 and nanogels 51,52 without markedly altering their size and structure.…”

Section: Introductionmentioning

confidence: 99%