2021
DOI: 10.1016/j.envpol.2020.115960
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Structural and functional analysis of the inhibition of equine glutathione transferase A3-3 by organotin endocrine disrupting pollutants

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Cited by 4 publications
(3 citation statements)
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“…Regarding the organotin compounds, a structure of triethyltin bromide as an inhibitor of the Alpha class GST A3-3 from horse was analyzed [40]. A corresponding homology model of the dog GST P1-1 in complex with triethyltin shows that the heavy atom can coordinate the oxygen of Tyr8, as well as the sulfur of glutathione, in a trigonal bipyramid structure similar to the one in the equine enzyme.…”
Section: Discussionmentioning
confidence: 99%
“…Regarding the organotin compounds, a structure of triethyltin bromide as an inhibitor of the Alpha class GST A3-3 from horse was analyzed [40]. A corresponding homology model of the dog GST P1-1 in complex with triethyltin shows that the heavy atom can coordinate the oxygen of Tyr8, as well as the sulfur of glutathione, in a trigonal bipyramid structure similar to the one in the equine enzyme.…”
Section: Discussionmentioning
confidence: 99%
“…6 A). The same compound gave IC 50 values of 0.28 ± 0.02 μM for EcaGST A3-3 [ 16 ] and 0.0023 μM for HsaGST A3-3 [ 2 ]. Ethacrynic acid likewise inhibited CjaGST A3-3 with an IC 50 value of 3.3 ± 0.2 μM ( Fig.…”
Section: Resultsmentioning
confidence: 99%
“…In addition, inhibitors of the GSTA3-3 enzyme have been identified that may be medically useful for reducing fertility or progression of steroid-dependent diseases [ 15 ]. These include the GST A3-3 enzyme inhibitors ethacrynic acid or tributyltin [ 32 ], or the small interfering RNAs that reduce GSTA3 gene expression [ 18 ].…”
Section: Discussionmentioning
confidence: 99%