Structural and Functional Brain Correlates of Neuroprogression in Bipolar Disorder

Librenza-Garcia, Diego; Suh, Jee Su; Watts, Devon; Ballester, Pedro; Minuzzi, Luciano; Kapczinski, Flávio; Frey, Benício N.

doi:10.1007/7854_2020_177

Cited by 11 publications

(10 citation statements)

References 81 publications

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“…In fact, the two disorders were also demonstrated to share common genetic heritage that two may be mediated by a variant of the Brain-Derived Neurotrophic Factor (BDNF), with possible epigenetic mechanisms that could act as response to traumatic and stressful life events [ 56 ]. Similarly, in neuroimaging studies alterations of the prefrontal cortex were detected in both conditions [ 57 , 58 ]. As a consequence, a better comprehension of the role that traumatic experiences play as possible mediators of BD development could also help shedding light on pathogenetic pathways that lead to the development of a clear-cut PTSD in BD subjects.…”

Section: Discussionmentioning

confidence: 96%

Environmental Risk Factors for Bipolar Disorders and High-Risk States in Adolescence: A Systematic Review

Menculini

Balducci

Attademo³

et al. 2020

Medicina

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Background and objectives: A deeper comprehension of the role that environmental risk factors play in the development of adolescent Bipolar Disorder (BD), as well as in the evolution of high-risk states for BD, may entangle further prevention and treatment advances. The present systematic review is aimed at critically summarizing evidence about the role that environmental risk factors play in the development of BD in adolescence and their interaction with BD high-risk states. Materials and Methods: MEDLINE/Pubmed, Scopus and Web of Science datasets were systematically searched until 4 September 2020. Original studies that reported information about the role of environmental risk factors in the development of BD during adolescence, or assessing their influence on the development of psychopathology in high-risk states for BD, were considered for inclusion. Two blind researchers performed title/abstract, full-text screening, and hand-screening of relevant references. The risk of bias was assessed by means of the Newcastle-Ottawa Scale. Results: Fourteen studies were included in the review. Negative stressful life events, particularly sexual and physical abuse, but also emotional mistreatment, were associated with more severe psychopathology in adolescents with BD, as well as with higher risk for developing mood disorders in BD offspring. Similar findings were detected for familial environment-related features, such as parental rejection and low perceived care, while no univocal results were found when analyzing familial functioning. Conclusions: The present systematic review confirmed the relevant role that environmental risk factors, particularly negative stressful live events and family-related features, play in the development of BD psychopathology during adolescence. Future studies are expected to clarify possible further environmental factors that may be implicated in the development of BD during youth that may serve as target of prevention and early treatment strategies.

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Section: Discussionmentioning

confidence: 96%

Environmental Risk Factors for Bipolar Disorders and High-Risk States in Adolescence: A Systematic Review

Menculini

Balducci

Attademo³

et al. 2020

Medicina

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“…Moreover, there is substantial evidence showing that early white matter changes, as well as trajectory-related gray matter alterations, including prefrontal, parietal, temporal cortex, and limbic structures, seem to be altered over the course of BD, which are especially associated with the number of episodes and length of the disease [ 110 ]. These findings support the notion that the damage of white matter tracts connecting cortical areas might hamper the connectivity between mood and cognition.…”

Section: Neural Circuits Of Bd As Revealed By Neuroimaging Techniqmentioning

confidence: 99%

Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature

et al. 2021

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Bipolar disorder (BD) is a chronic and disabling psychiatric condition that is linked to significant disability and psychosocial impairment. Although current neuropsychological, molecular, and neuroimaging evidence support the existence of neuroprogression and its effects on the course and outcome of this condition, whether and to what extent neuroprogressive changes may impact the illness trajectory is still poorly understood. Thus, this selective review was aimed toward comprehensively and critically investigating the link between BD and neurodegeneration based on the currently available evidence. According to the most relevant findings of the present review, most of the existing neuropsychological, neuroimaging, and molecular evidence demonstrates the existence of neuroprogression, at least in a subgroup of BD patients. These studies mainly focused on the most relevant effects of neuroprogression on the course and outcome of BD. The main implications of this assumption are discussed in light of specific shortcomings/limitations, such as the inability to carry out a meta-analysis, the inclusion of studies with small sample sizes, retrospective study designs, and different longitudinal investigations at various time points.

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“…Substantial evidence shows that white matter changes seem to be altered over the course of BD, and are especially associated with the number of epi sodes and severity. [56][57][58] It is conceivable that participants in depressive or manic states may exhibit a higher propensity for mood cycling, or a distinct ratio of manictodepressive episodes, in contrast to participants who are in a euthymic state during the scan. In such a scenario, one could postulate that the observed variations in global efficiency may be attrib uted to the cumulative impact arising from the number of de pressive or manic episodes throughout the course of the ill ness.…”

Section: Cross-validation Among People At High Genetic Risk Of Bdmentioning

confidence: 99%

State- and trait-related dysfunctions in bipolar disorder across different mood states: a graph theory study

Chen,

Zhao,

Pan

et al. 2024

jpn

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Background: The interplay between state- and trait-related disruptions in structural networks remains unclear in bipolar disorder (BD), but graph theory can offer insights into global and local network changes. We sought to use diffusion-tensor imaging (DTI) and graph theory approaches to analyze structural topological properties across distinct mood states and identify high-risk individuals by examining state- and trait-related impairments in BD. Methods: We studied changes in white matter network among patients with BD and healthy controls, exploring relationships with clinical variables. Secondary analysis involved comparing patients with BD with unaffected people at high genetic risk for BD. Results: We included 152 patients with BD, including 52 with depressive BD (DBD), 64 with euthymic BD (EBD) and 36 with manic BD (MBD); we also included 75 healthy controls. Secondary analyses involved 27 unaffected people at high genetic risk for BD. Patients with DBD and MBD exhibited significantly lower global efficiencies than those with EBD and healthy controls, with patients with DBD showing the lowest global efficiencies. In addition, patients with DBD displayed impaired local efficiency and normalized clustering coefficient (γ). At a global level, γ correlated negatively with depression and anxiety. Compared with healthy controls, and across mood states, patients with BD showed abnormal shortest path lengths in the frontolimbic circuit, a trend mirrored among those at high genetic risk for BD. Limitations: Considerations include medication effects, absence of recorded BD episode counts and the cross-sectional nature of the study. Conclusion: Mood-specific whole-brain network metrics could serve as potential biomarkers in BD for transitions between mood states. Moreover, these findings contribute to evidence of trait-related frontolimbic circuit irregularities, shedding light on underlying pathophysiological mechanisms in BD.

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Structural and Functional Brain Correlates of Neuroprogression in Bipolar Disorder

Cited by 11 publications

References 81 publications

Environmental Risk Factors for Bipolar Disorders and High-Risk States in Adolescence: A Systematic Review

Environmental Risk Factors for Bipolar Disorders and High-Risk States in Adolescence: A Systematic Review

Neuroprogression as an Illness Trajectory in Bipolar Disorder: A Selective Review of the Current Literature

State- and trait-related dysfunctions in bipolar disorder across different mood states: a graph theory study

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