Structural and functional characterisation of HepTH1-5 peptide as a potential hepcidin replacement

Azemin, Wan-Atirah; Alias, Nadiawati; Ali, Abdul Manaf; Shamsir, Mohd Shahir

doi:10.1080/07391102.2021.2011415

Cited by 4 publications

(2 citation statements)

References 246 publications

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“…The Correlation of Hepcidin with Hemoglobin and Iron Parameters Qad.Med.J. 19(1): [9][10][11][12][13][14]2023 globin (β-globin) in human hemoglobin (Hb) are responsible for this (5).…”

Section: Introductionmentioning

confidence: 99%

“…In Beta-thalassemia, Hepcidin suppression enhances the severity of iron overload by increasing iron absorption in cases of iron overload with inadequate erythropoiesis, This extra iron collects in nonhematopoietic tissue's parenchyma. Because the capacity of transferrin to carry iron is finally exceeded by increased iron absorption, suppressed hepcidin causes the synthesis of nontransferrin-bound iron, which is not useful for erythropoiesis (10).…”

Section: Introductionmentioning

confidence: 99%

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Correlation of Hepcidin with Hemoglobin and Iron Parameters in Iraqi Patients with Beta -Thalassemia major

Nahi,

Jabir

2023

Qad Med J

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Background: Thalassemia is characterized by genetic abnormalities in the synthesis of hemoglobin, leading to a decrease or missing production of one or more in the globin chains. Consequently, this disrupts the synthesis of hemoglobin molecules, resulting in anemia, which is a prominent manifestation of thalassemia. Iron is an essential element for cellular health and is involved in various functions, including oxygen transportation, biomolecule synthesis, respiration, and homeostasis. Hepcidin, a low molecular weight peptide produced in the liver, plays a crucial role in regulating iron homeostasis. Objectives: Study the correlation of Hepcidin with Hemoglobin, Ferritin, and Iron Parameters in Patients with Beta-Thalassemia major. Methods: The serum ferritin of all subjects was measured by the ELFA technique (Enzyme Linked Fluorescent Assay), Serum Hepcidin is measured by the ELISA kit, and Iron, UIBC as well as TIBC are measured via colorimetric methods. Results: The { mean ± SD } of Ages and Genders among Patients with healthy groups were not significant. The { mean ± SD } of Hb and serum levels of Iron, UIBC, TIBC, Hepcidin concentration, and BMI between Patients and healthy groups were statistically significant. The study results of the correlation between Hepcidin and other markers in the beta-thalassemia patient's group showed a non-significant negative correlation of hepcidin with TIBC and UIBC. while there is a non-significant weak correlation between hepcidin with Hb and Ferritin. and the results have shown a non-significant positive correlation between hepcidin and Iron. Conclusion: In this study showed a marked reduction in hemoglobin production and high levels of Iron and Ferritin concentration, while the concentration of TIBC and UIBC was observed to decrease in individuals with this disease compared to healthy individuals. This study showed low hepcidin concentration in ?-TM major patients compared to healthy subjects.

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“…The Correlation of Hepcidin with Hemoglobin and Iron Parameters Qad.Med.J. 19(1): [9][10][11][12][13][14]2023 globin (β-globin) in human hemoglobin (Hb) are responsible for this (5).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlation of Hepcidin with Hemoglobin and Iron Parameters in Iraqi Patients with Beta -Thalassemia major

Nahi,

Jabir

2023

Qad Med J

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Targeting iron metabolism in osteosarcoma

Zhao

Feng

2023

Discov Onc

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Osteosarcoma (OS) is the most common primary solid malignant tumour of bone, with rapid progression and a very poor prognosis. Iron is an essential nutrient that makes it an important player in cellular activities due to its inherent ability to exchange electrons, and its metabolic abnormalities are associated with a variety of diseases. The body tightly regulates iron content at the systemic and cellular levels through various mechanisms to prevent iron deficiency and overload from damaging the body. OS cells regulate various mechanisms to increase the intracellular iron concentration to accelerate proliferation, and some studies have revealed the hidden link between iron metabolism and the occurrence and development of OS. This article briefly describes the process of normal iron metabolism, and focuses on the research progress of abnormal iron metabolism in OS from the systemic and cellular levels.

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In silico analysis prediction of HepTH1-5 as a potential therapeutic agent by targeting tumour suppressor protein networks

Azemin

Alias

Ali

et al. 2021

Journal of Biomolecular Structure and Dynamics

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Structural and functional characterisation of HepTH1-5 peptide as a potential hepcidin replacement

Cited by 4 publications

References 246 publications

Correlation of Hepcidin with Hemoglobin and Iron Parameters in Iraqi Patients with Beta -Thalassemia major

Correlation of Hepcidin with Hemoglobin and Iron Parameters in Iraqi Patients with Beta -Thalassemia major

Targeting iron metabolism in osteosarcoma

In silico analysis prediction of HepTH1-5 as a potential therapeutic agent by targeting tumour suppressor protein networks

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