2024
DOI: 10.1107/s2053230x2400356x
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Structural and functional characterization of FabG4 from Mycolicibacterium smegmatis

Xinping Ran,
Prashit Parikh,
Jan Abendroth
et al.

Abstract: The rise in antimicrobial resistance is a global health crisis and necessitates the development of novel strategies to treat infections. For example, in 2022 tuberculosis (TB) was the second leading infectious killer after COVID-19, with multi-drug-resistant strains of TB having an ∼40% fatality rate. Targeting essential biosynthetic pathways in pathogens has proven to be successful for the development of novel antimicrobial treatments. Fatty-acid synthesis (FAS) in bacteria proceeds via the type II pathway, w… Show more

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