Structural and Functional Connectivity of the Anterior Cingulate Cortex in Patients With Borderline Personality Disorder

Lei, Xuelin; Zhong, Mingtian; Zhang, Bowen; Yang, Huanming; Peng, Wanrong; Liu, Qian; Yao, Shuqiao; Tan, Chongqing; Yi, Jinyao

doi:10.3389/fnins.2019.00971

Cited by 23 publications

(13 citation statements)

References 71 publications

(81 reference statements)

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“…Resting-state FC, focusing on the statistical correlation between signals in the whole brain or regional brain areas ( Fox and Raichle, 2007 ), has shown substantial clinical research potential for exploring synchronous brain activity, which is also the highlight of the current research. Region-of-interest (ROI) studies based on resting-state FC have been considered sensitive and reliable ( Hampson et al, 2002 ), and these techniques have been widely applied in various objective analyses of brain functional activity, varying from sleep disorders to neuropsychiatric diseases ( Lei et al, 2019 ; Guo et al, 2020 ). Thus, resting-state FC studies based on ROI may be incredibly useful in evaluating insular FC integrity in patients with OSA.…”

Section: Introductionmentioning

confidence: 99%

Aberrant Resting-State Functional Brain Connectivity of Insular Subregions in Obstructive Sleep Apnea

Kong

Shu

et al. 2022

Front. Neurosci.

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The insular cortex is a cortical regulatory area involved in dyspnea, cognition, emotion, and sensorimotor function. Previous studies reported that obstructive sleep apnea (OSA) shows insular tissue damage and abnormal functional connections for the whole insula. The insula can be divided into different subregions with distinct functional profiles, including the ventral anterior insula (vAI) participating in affective processing, dorsal anterior insula (dAI) involved in cognitive processing, and posterior insula (PI) involved in the processing of sensorimotor information. However, the functional connectivity (FC) of these insular subregions in OSA has yet to be established. Hence, the purpose of this study was to explore the resting-state FC of the insular subregions with other brain areas and its relationship with clinical symptoms of OSA. Resting-state functional magnetic resonance imaging data from 83 male OSA patients and 84 healthy controls were analyzed by whole-brain voxel-based FC using spherical seeds from six insular subregions, namely, the bilateral vAI, dAI, and PI, to identify abnormalities in the insular subregions network and related brain regions. Ultimately, the Pearson correlation analysis was carried out between the dysfunction results and the neuropsychological tests. Compared with the healthy control group, the OSA patients exhibited disturbed FC from the dAI to areas relevant to cognition, such as the bilateral cerebellum posterior lobe, superior frontal gyrus, right middle frontal gyrus and middle temporal gyrus; decreased FC from the vAI to areas linked with emotion, such as the bilateral fusiform gyrus, superior parietal lobule, precuneus and cerebellum posterior lobe; and abnormal FC from the PI to the brain regions involved in sensorimotor such as the bilateral precentral gyrus, right superior/middle temporal gyrus and left superior frontal gyrus. The linear regression result showed that the apnea-hypopnea index was positively correlated with the increased FC between the right PI and the right precuneus (after Bonferroni correlation, P < 0.001) In conclusion, the abnormal FC between insular subregions and other brain regions were related to cognitive, emotional and sensorimotor networks in OSA patients. These results may provide a new imaging perspective for further understanding of OSA-related cognitive and affective disorders.

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Section: Introductionmentioning

confidence: 99%

Aberrant Resting-State Functional Brain Connectivity of Insular Subregions in Obstructive Sleep Apnea

Kong

Shu

et al. 2022

Front. Neurosci.

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“…Previous studies have reported that patients with MDD had a 2%-12% lifetime risk of dying by suicide (4,5), and the new study reported that the rated of suicide attempts (SA) was greater 4.78% in MDD by assessments of 3,284 adults with/without suicidal acts (6). Therefore, finding neurological features relating to SA in MDD patients could be a major achievement in preventing suicidal behavior (7).…”

Section: Introductionmentioning

confidence: 99%

Structural and Functional Abnormities of Amygdala and Prefrontal Cortex in Major Depressive Disorder With Suicide Attempts

et al. 2020

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Finding neural features of suicide attempts (SA) in major depressive disorder (MDD) may be helpful in preventing suicidal behavior. The ventral and medial prefrontal cortex (PFC), as well as the amygdala form a circuit implicated in emotion regulation and the pathogenesis of MDD. The aim of this study was to identify whether patients with MDD who had a history of SA show structural and functional connectivity abnormalities in the amygdala and PFC relative to MDD patients without a history of SA. We measured gray matter volume in the amygdala and PFC and amygdala-PFC functional connectivity using structural and functional magnetic resonance imaging (MRI) in 158 participants [38 MDD patients with a history of SA, 60 MDD patients without a history of SA, and 60 healthy control (HC)]. MDD patients with a history of SA had decreased gray matter volume in the right and left amygdala (F = 30.270, P = 0.000), ventral/medial/dorsal PFC (F = 15.349, P = 0.000), and diminished functional connectivity between the bilateral amygdala and ventral and medial PFC regions (F = 22.467, P = 0.000), compared with individuals who had MDD without a history of SA, and the HC group. These findings provide evidence that the amygdala and PFC may be closely related to the pathogenesis of suicidal behavior in MDD and implicate the amygdala-ventral/medial PFC circuit as a potential target for suicide intervention.

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“…113 The altered processing of fearful stimuli may also clarify why persons with BPD have a heightened fear of abandonment and instability when compared to persons without BPD. 114 BPD-rs-4, 115 BPD-rs-6, 116 and BPD-rs-7 117 highlight aberrations in FC of the ACC. The ACC is involved in various cognitive processes, such as motivation, decision making, emotion processing, learning, and conflict and error monitoring.…”

Section: Bpd Resting-state Summarymentioning

confidence: 99%

Functional MRI findings in personality disorders: A review

Zarnowski

Ziton

Holmberg

et al. 2021

Journal of Neuroimaging

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Personality disorders (PDs) have a prevalence of approximately 10% in the United States, translating to over 30 million people affected in just one country. The true prevalence of these disorders may be even higher, as the paucity of objective diagnostic criteria could be leading to underdiagnosis. Because little is known about the underlying neuropathologies of these disorders, patients are diagnosed using subjective criteria and treated nonspecifically. To better understand the neural aberrancies responsible for these patients' symptoms, a review of functional MRI literature was performed. The findings reveal that each PD is characterized by a unique set of activation changes corresponding to individual structures or specific neural networks. While unique patterns of neural activity are distinguishable within each PD, aberrations of the limbic/paralimbic structures and default mode network are noted across several of them. In addition to identifying valuable activation patterns, this review reveals a void in research pertaining to paranoid, schizoid, histrionic, narcissistic, and dependent PDs. By delineating patterns in PD neuropathology, we can more effectively direct future research efforts toward enhancing objective diagnostic techniques and developing targeted treatment modalities. Furthermore, understanding why patients are manifesting certain symptoms can advance clinical awareness and improve patient outcomes.

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Structural and Functional Connectivity of the Anterior Cingulate Cortex in Patients With Borderline Personality Disorder

Cited by 23 publications

References 71 publications

Aberrant Resting-State Functional Brain Connectivity of Insular Subregions in Obstructive Sleep Apnea

Aberrant Resting-State Functional Brain Connectivity of Insular Subregions in Obstructive Sleep Apnea

Structural and Functional Abnormities of Amygdala and Prefrontal Cortex in Major Depressive Disorder With Suicide Attempts

Functional MRI findings in personality disorders: A review

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