Structural and functional disorders of hippocampus following ischemia/reperfusion in lower limbs and kidneys

Karimi, Narges; Haghani, Masoud; Noorafshan, Ali; Moosavi, Seyed Mostafa Shid

doi:10.1016/j.neuroscience.2017.06.058

Cited by 14 publications

(10 citation statements)

References 51 publications

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“…This renal IRI model results in raise of Cr, BUN, KW, and kidney damage score as indexes of renal functional and structural insult in both genders that showed our result is in line with the other researches. [ 9 17 18 21 ] Also in both genders, histology of kidney proved tubular damages such as necrosis, atrophy, presence of hyaline cast, vacuolization, inflammation, and congestion of vessels. In line with this result, Fekete et al .…”

Section: Discussionmentioning

confidence: 98%

“…Brain insult in the different levels of structure, biochemistry, inflammation, and behavior reported renal ischemia consequence. [ 6 7 8 9 10 11 ] Inflammatory and functional changes of male mice’s brain following ischemic AKI have been shown by Liu et al . [ 10 ] Most of these researches have been done on male rats, but it is certain that kidney diseases are gender related.…”

Section: Introductionmentioning

confidence: 99%

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The influence of renal ischemia-reperfusion injury on remote organs

et al. 2021

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INTRODUCTION: Brain tissue was adversely affected by renal ischemia-reperfusion injury (renal IRI) in several studies. Moreover, we are awareness that kidney diseases are gender dependent, but there is not enough evidence of the impact of gender on renal IRI-induced brain injury. Hence, this study was designed to investigate gender differences in renal IRI-induced brain tissue injury in adult rats. MATERIALS AND METHODS: Forty Wistar rats (four groups) include two main groups (20 male and 20 female). Each of them was divided into two subgroups including 1 and 2: male and female sham-operated groups and 3and 4: male and female ischemia (ISC) groups were exposed to renal ischemia for 45 min and then 24 h reperfusion (male and female ISC 24 h). Sham groups were exposed to surgery without ischemia process. After reperfusion time, blood samples were obtained for the renal function measurements. The kidney and brain were removed and were fixed in a 10% formalin solution for pathological assessment. The left kidney was used to measure malondialdehyde (MDA) and nitrite. RESULTS: Renal IRI increased significantly levels of creatinine, blood urea nitrogen, kidney weight, and damage score in both genders ( P < 0.05). Furthermore, brain injuries were significantly higher following 24 h of reperfusion in male and female groups. Serum nitrite level and MDA concentration of female rats decreased significantly in ISC 24 h group ( P < 0.05) but not in male rats. CONCLUSION: The brain tissue of both genders, male and female, is affected by renal IRI as a remote organ. Female sex hormones may indicate a protective role against IR by the nitric oxide pathway and antioxidant signaling.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

The influence of renal ischemia-reperfusion injury on remote organs

et al. 2021

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“…By contrast, the obtained results from other groups revealed no changes in biochemical markers, which further confirmed their behavioral responses. In support of this, Karimi et al indicated that 45 min renal ischemia cannot significantly affect the number of CA1 neurons and long-term synaptic plasticity of the CA1 hippocampal synapses, because of inadequate deleterious strength of this ischemia duration [32]. In addition, Liu et al found that 60 min renal ischemia has much more deleterious effects on cerebral structures than 45 min ischemia [33].…”

Section: Discussionmentioning

confidence: 99%

Synaptic plasticity in hippocampal CA1 neurons and learning behavior in acute kidney injury, and estradiol replacement in ovariectomized rats

2019

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Background: Neurological complications may occur in patients with acute or chronic renal failure; however, in cases of acute renal failure, the signs and symptoms are usually more pronounced, and progressed rapidly. Oxidative stress and nitric oxide in the hippocampus, following kidney injury may be involved in cognitive impairment in patients with uremia. Although many women continue taking hormone therapy for menopausal symptom relief, but there are also some controversies about the efficacy of exogenous sex hormones, especially estrogen therapy alone, in postmenopausal women with kidney injury. Herein, to the best of our knowledge for the first time, spatial memory and synaptic plasticity at the CA1 synapse of a uremic ovariectomized rat model of menopause was characterized by estradiol replacement alone. Results: While estradiol replacement in ovariectomized rats without uremia, promotes synaptic plasticity, it has an impairing effect on spatial memory through hippocampal oxidative stress under uremic conditions, with no change on synaptic plasticity. It seems that exogenous estradiol potentiated the deleterious effect of acute kidney injury (AKI) with increasing hippocampal oxidative stress. Conclusions: Although, estrogen may have some positive effects on cognitive function in healthy subjects, but its efficacy in menopause subjects under uremic states such as renal transplantation, needs to be further investigated in terms of dosage and duration.

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“…More specifically, inflammation, oxidative stress, mitochondrial, and vascular dysfunction are key factors in the pathophysiology of both PAD and neurodegenerative diseases [12,20,21,22]. Thus, although an experimental study failed to demonstrated brain mitochondrial dysfunction in the setting of aortic clamping [23], peripheral inflammatory factors released during the ischemic process have been shown to impair several remote organs, including the brain [24,25] (Figure 1).…”

Section: Cognitive Function In Patients With Peripheral Arterial Dmentioning

confidence: 99%

Beneficial Effect of Exercise on Cognitive Function during Peripheral Arterial Disease: Potential Involvement of Myokines and Microglial Anti-Inflammatory Phenotype Enhancement

Leardini-Tristão

Charles

Lejay

et al. 2019

JCM

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Peripheral arterial disease (PAD), leading to intermittent claudication, critical ischemia with rest pain, and/or tissue damage, is a public health issue associated with significant morbidity and mortality. Little is known about the link between PAD, cognitive function, and whether exercise might reduce cognitive dysfunction in PAD patients, as previously observed concerning both quality of life and prognosis. This review highlights the fact that patients suffering from PAD often demonstrate cognitive dysfunction characterized by reduced performance in nonverbal reasoning, reduced verbal fluency, and decreased information processing speed and a greater risk for progression toward dementia. Further, the data presented support that physical exercise, likely through myokine secretion and microglial anti-inflammatory phenotype enhancement, might participate in the cognition protection in common clinical settings.

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Structural and functional disorders of hippocampus following ischemia/reperfusion in lower limbs and kidneys

Cited by 14 publications

References 51 publications

The influence of renal ischemia-reperfusion injury on remote organs

The influence of renal ischemia-reperfusion injury on remote organs

Synaptic plasticity in hippocampal CA1 neurons and learning behavior in acute kidney injury, and estradiol replacement in ovariectomized rats

Beneficial Effect of Exercise on Cognitive Function during Peripheral Arterial Disease: Potential Involvement of Myokines and Microglial Anti-Inflammatory Phenotype Enhancement

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