Structural and functional features of the colon in patients with non-alcoholic fatty liver disease and comorbid pathology

Abstract

Purpose of the study: to establish the clinical and diagnostic signifi cance of structural and functional changes in the colon in NAFLD against the background of obesity, type 2 diabetes, arterial hypertension.Materials and methods: 138 patients with NAFLD and intestinal pathology, 36 patients without intestinal dysfunction were examined. The clinical and endoscopic features of lesions of the colon mucosa in patients with NAFLD were studied, taking into account the underlying pathology (obesity, type 2 diabetes, arterial hypertension). Changes in intestinal microbiocenosis were revealed in patients with NAFLD, depending on the underlying pathology. The morphometric parameters of the expression of colonocytes immunopositive to the vascular endothelial growth factor, as well as to leptin, were studied in comparison with the clinical and endoscopic features of the colon and liver, and the presence of a background disease.Results: It has been established that the background diseases in NAFLD — type 2 diabetes and obesity — make a certain contribution to the structural and functional changes in the colon. In turn, changes in the intestinal microbiota in NAFLD against the background of obesity, type 2 diabetes lead to aggravation of dyslipidemia, glycemia with the progression of chronic systemic infl ammation and fi brosis in the liver.