Structural and functional imaging of psoriasis for severity assessment and quantitative monitoring of treatment response using high-resolution optoacoustic imaging

Li, Xiuting; Yew, Yik Weng; Vinod Ram, Keertana; Oon, Hazel H.; Thng, Steven Tien Guan; Dinish, U.S.; Olivo, Malini

doi:10.1016/j.pacs.2024.100611

Photoacoustics

2024

DOI: 10.1016/j.pacs.2024.100611

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Structural and functional imaging of psoriasis for severity assessment and quantitative monitoring of treatment response using high-resolution optoacoustic imaging

Xiuting Li,

Yik Weng Yew,

Keertana Vinod Ram

et al.

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Cited by 3 publications

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Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In Vivo

Kim,

Kweon,

Choi

et al. 2024

Advanced Science

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Early‐stage stroke monitoring enables timely intervention that is crucial to minimizing neuronal damage and increasing the extent of recovery. By monitoring collateral circulation and neovascularization after ischemic stroke, the natural recovery process can be better understood, optimize further treatment strategies, and improve the prognosis. Photoacoustic computed tomography (PACT), a non‐invasive imaging modality that captures multiparametric high‐resolution images of vessel structures, is well suited for evaluating cerebrovascular structures and their function. Here 3D multiparametric transcranial PACT is implemented to monitor the early stage of a photothrombotic (PT)‐stroke model in living rats. New vessels in the PT‐induced region are successfully observed using PACT, and these observations are confirmed by histology. Then, using multiparametric PACT, it is found that the SO2 in the ischemic area decreases while the SO2 in newly formed vessels increases, and the SO2 in the PT region also recovers. These findings demonstrate PACT's remarkable ability to image and monitor cerebrovascular morphologic and physiological changes. They highlight the usefulness of whole‐brain PACT as a potentially powerful tool for early diagnosis and therapeutic decision‐making in treating ischemic stroke.

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Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In Vivo

Kim,

Kweon,

Choi

et al. 2024

Advanced Science

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Review on Photoacoustic Monitoring after Drug Delivery: From Label-Free Biomarkers to Pharmacokinetics Agents

Kim,

Choi,

Kim

et al. 2024

Pharmaceutics

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Photoacoustic imaging (PAI) is an emerging noninvasive and label-free method for capturing the vasculature, hemodynamics, and physiological responses following drug delivery. PAI combines the advantages of optical and acoustic imaging to provide high-resolution images with multiparametric information. In recent decades, PAI’s abilities have been used to determine reactivity after the administration of various drugs. This study investigates photoacoustic imaging as a label-free method of monitoring drug delivery responses by observing changes in the vascular system and oxygen saturation levels across various biological tissues. In addition, we discuss photoacoustic studies that monitor the biodistribution and pharmacokinetics of exogenous contrast agents, offering contrast-enhanced imaging of diseased regions. Finally, we demonstrate the crucial role of photoacoustic imaging in understanding drug delivery mechanisms and treatment processes.

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In vivo multi-scale clinical photoacoustic imaging for analysis of skin vasculature and pigmentation: a comparative review

Ahn,

Kim,

Kim

et al. 2024

Advanced Imaging

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Structural and functional imaging of psoriasis for severity assessment and quantitative monitoring of treatment response using high-resolution optoacoustic imaging

Cited by 3 publications

References 42 publications

Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In Vivo

Non‐Invasive Photoacoustic Cerebrovascular Monitoring of Early‐Stage Ischemic Strokes In Vivo

Review on Photoacoustic Monitoring after Drug Delivery: From Label-Free Biomarkers to Pharmacokinetics Agents

In vivo multi-scale clinical photoacoustic imaging for analysis of skin vasculature and pigmentation: a comparative review

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