Structural and functional profiles of the gut microbial community in polycystic ovary syndrome with insulin resistance (IR-PCOS): a pilot study

Zeng, Bo; Lai, Zhiwen; Sun, Lijin; Zhang, Zhongbao; Yang, Jianhua; Li, Zaixin; Lin, Jie Kuan; Zhang, Zhi

doi:10.1016/j.resmic.2018.09.002

Cited by 138 publications

(120 citation statements)

References 56 publications

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“…Currently, there is a preference for researchers to use sequencing technology to classify, identify, and accurately quantify intestinal bacteria. Lately, several leading studies have demonstrated that microbiota dysbiosis occurs in PCOS animal models and PCOS patients [18][19][20][21][22]. Of note, a change in the overall composition of the gut bacteria has been associated with PCOS, including a decrease in alpha and beta diversity.…”

Section: Pcos and Gut Microbiotamentioning

confidence: 99%

“…Several studies have reported a decrease in α diversity and a change in β diversity in patients with PCOS [18,20]. Zeng et al Zeng et al found a lower number of observed operational taxonomic units (OTUs) and a lower Shannon index in IR-PCOS group of patients after comparing its structural and functional profiles of the gut microbial community withNIR-PCOS [22]. They further showed that hierarchical clustering could distinguish samples from the healthy control (HC) group with the IR-PCOS group [22].…”

Section: Pcos and Microbiota Diversitymentioning

confidence: 99%

“…Actually, gut microbiota composition in patients with PCOS was significantly altered compared with women without PCOS as shown in recent study. Moreover, intestinal flora disorders have been closely associated with clinical symptoms such as obesity and IR [18][19][20][21][22]. However, there lacks full understanding on mechanism of gut microbiota in patients with PCOS [23,24].…”

Section: Introductionmentioning

confidence: 99%

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Role of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome: a review

2020

J Ovarian Res

176

132

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Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder. Typically, it is characterized by hirsutism, hyperandrogenism, ovulatory dysfunction, menstrual disorders and infertility. To date, its pathogenesis remains unclear. However, insulin resistance (IR) is considered as the primary pathological basis for its reproductive dysfunction. On the other hand, a condition in which insulin is over-secreted is called hyperinsulinemia. IR/ Hyperinsulinemia is associated with chronic inflammation, hormonal changes, follicular dysplasia, endometrial receptivity changes, and abortion or infertility. Additionally, it increases incidence of complications during pregnancy and has been associated with anxiety, depression, and other psychological disorders. Gut microbiota, the "second genome" acquired by the human body, can promote metabolism, immune response through interaction with the external environment. Gut microbiota dysbiosis can cause IR, which is closely linked to the occurrence of PCOS. This article reviewed recent findings on the roles of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome.

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Section: Pcos and Gut Microbiotamentioning

confidence: 99%

Section: Pcos and Microbiota Diversitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome: a review

2020

J Ovarian Res

176

132

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“…Ecological imbalance of gut microbiota leads to increased intestinal permeability. Intestinal-derived LPS enters into the circulation through the "intestine leaking" wall to induce systemic low-grade inflammation, leading to increased testosterone production of ovaries in the formation of PCOS [7,11,12].…”

mentioning

confidence: 99%

Inulin and metformin ameliorate polycystic ovary syndrome <i>via</i> anti-inflammation and modulating gut microbiota in mice

Xue

Liu

et al. 2019

Endocr J

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Polycystic ovary syndrome (PCOS) represents an endocrine disorder, which is closely related with gut microbiota. Inulin, a kind of probiotics, has been proven to alleviate gut microbiota dysbiosis. Metformin, a biguanide agent, shows beneficial effects on chronic metabolic diseases. Our objective was to assess the effects and associated mechanisms of inulin and metforin on attenuation of PCOS in mice. Mice were divided into 4 groups: control group (CON), model group (MOD), inulin group (INU), metformin group (MET). The last three groups were fed 6 mg of dehydroepiandrosterone (DHEA) per 100 g body weight and 60% high-fat diet to generate mice model. After 21 days of intervention, mice were euthanized and associated indications were investigated. Body weight (BW) and testosterone (T) levels were significantly decreased, but estradiol (E2) levels were increased in INU or MET group, respectively. Ovary HE staining demonstrated that inulin or metformin ameliorated PCOS morphology. Inflammatory indicators from plasma and ovary including TNF-α, IL-6, and IL-17A were decreased in INU or MET group. Moreover, IL-10 in ovary of INU or MET group was increased. Sequencing and analysis of gut microbiota showed that compared to MOD group, Bifidobacterium was increased, but Proteobacteria, Helicobacter and Parasutterella were decreased in INU group. Helicobacter was decreased in MET group. Correlation analysis showed that gut microbiota was correlated with inflammatory factors. Our results revealed that inulin and metformin alleviated PCOS via anti-inflammation and modulating gut microbiota, which may contribute to potential clinical therapy for the disease.

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“…The most unique and habitually encountered endocrine malfunction in women is polycystic ovary syndrome (PCOS) (Qin et al, 2015;Sóter et al, 2015;Xing et al, 2017). Overproduction of androgens, ovulatory malfunctions, and other anomalies in ovarian morphology (Zhang et al, 2015) are some of the characteristics of PCOS, which is found in approximately 9-21% women of reproductive age (Yamada et al, 2017;Zeng et al, 2018). PCOS is thought of as a biological issue that impacts including other body systems, for example, those associated with psychological structure and metabolic, and procreative systems (Talaat et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Research Article Lack of association between IL10 and TNFα gene polymorphisms and polycystic ovary syndrome in Saudi women

Alkhuriji¹,

Alomar²,

Babay³

et al. 2019

Genet. Mol. Res.

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Structural and functional profiles of the gut microbial community in polycystic ovary syndrome with insulin resistance (IR-PCOS): a pilot study

Cited by 138 publications

References 56 publications

Role of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome: a review

Role of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome: a review

Inulin and metformin ameliorate polycystic ovary syndrome <i>via</i> anti-inflammation and modulating gut microbiota in mice

Research Article Lack of association between IL10 and TNFα gene polymorphisms and polycystic ovary syndrome in Saudi women

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